Fangmian Wei , Johannes Karges , Siyuan Gao , Lili Wang , Xiting Zhang , Xing-Can Shen , Liangnian Ji , Hui Chao
{"title":"钌(II)配位碳氮中ROS风暴的双光子光触发对癌症免疫治疗的影响","authors":"Fangmian Wei , Johannes Karges , Siyuan Gao , Lili Wang , Xiting Zhang , Xing-Can Shen , Liangnian Ji , Hui Chao","doi":"10.1016/j.nantod.2023.102066","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The use of Ru(II) polypyridine complexes for photodynamic therapy is receiving much attention. Despite their promising properties, these compounds are associated with a poor excitation in the biological spectral window, a highly reduced or complete loss of the therapeutic effect under hypoxic conditions, and no immune response, limiting their application. To overcome all these limitations, herein, the coordination of Ru(II) polypyridine complexes to </span>graphitic carbon nitride<span><span> nanosheets<span> for oxygen-self-sufficient two-photon photodynamic immunotherapy is presented. The conjugates were found with an exceptionally strong two-photon absorption and could self-sufficiently produce an </span></span>ROS storm consisting of </span></span><sup>•</sup>O<sub>2</sub><sup>-</sup>, <sup>•</sup>OH, and <sup>1</sup>O<sub>2</sub><span><span><span>. Upon two-photon irradiation, the nanomaterial induced cell death in hypoxic monolayer cancer cells and multicellular </span>tumor spheroids<span> by a combination of apoptosis, paraptosis, </span></span>ferroptosis, and immunogenic cell death. The nanomaterial was found with a strong tumor growth inhibition against the primary and secondary distant tumor in a melanoma-bearing mouse model through activation of the immune system.</span></p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two-photon phototriggering of ROS storm in ruthenium(II) coordinated carbon nitride for robust cancer immunotherapy\",\"authors\":\"Fangmian Wei , Johannes Karges , Siyuan Gao , Lili Wang , Xiting Zhang , Xing-Can Shen , Liangnian Ji , Hui Chao\",\"doi\":\"10.1016/j.nantod.2023.102066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The use of Ru(II) polypyridine complexes for photodynamic therapy is receiving much attention. Despite their promising properties, these compounds are associated with a poor excitation in the biological spectral window, a highly reduced or complete loss of the therapeutic effect under hypoxic conditions, and no immune response, limiting their application. To overcome all these limitations, herein, the coordination of Ru(II) polypyridine complexes to </span>graphitic carbon nitride<span><span> nanosheets<span> for oxygen-self-sufficient two-photon photodynamic immunotherapy is presented. The conjugates were found with an exceptionally strong two-photon absorption and could self-sufficiently produce an </span></span>ROS storm consisting of </span></span><sup>•</sup>O<sub>2</sub><sup>-</sup>, <sup>•</sup>OH, and <sup>1</sup>O<sub>2</sub><span><span><span>. Upon two-photon irradiation, the nanomaterial induced cell death in hypoxic monolayer cancer cells and multicellular </span>tumor spheroids<span> by a combination of apoptosis, paraptosis, </span></span>ferroptosis, and immunogenic cell death. The nanomaterial was found with a strong tumor growth inhibition against the primary and secondary distant tumor in a melanoma-bearing mouse model through activation of the immune system.</span></p></div>\",\"PeriodicalId\":395,\"journal\":{\"name\":\"Nano Today\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.2000,\"publicationDate\":\"2023-11-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano Today\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1748013223003158\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013223003158","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Two-photon phototriggering of ROS storm in ruthenium(II) coordinated carbon nitride for robust cancer immunotherapy
The use of Ru(II) polypyridine complexes for photodynamic therapy is receiving much attention. Despite their promising properties, these compounds are associated with a poor excitation in the biological spectral window, a highly reduced or complete loss of the therapeutic effect under hypoxic conditions, and no immune response, limiting their application. To overcome all these limitations, herein, the coordination of Ru(II) polypyridine complexes to graphitic carbon nitride nanosheets for oxygen-self-sufficient two-photon photodynamic immunotherapy is presented. The conjugates were found with an exceptionally strong two-photon absorption and could self-sufficiently produce an ROS storm consisting of •O2-, •OH, and 1O2. Upon two-photon irradiation, the nanomaterial induced cell death in hypoxic monolayer cancer cells and multicellular tumor spheroids by a combination of apoptosis, paraptosis, ferroptosis, and immunogenic cell death. The nanomaterial was found with a strong tumor growth inhibition against the primary and secondary distant tumor in a melanoma-bearing mouse model through activation of the immune system.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.