在创伤患者中实施强制性血液酒精筛查:一项来自中东国家三级创伤中心的回顾性研究

IF 2.5 4区 医学 Q3 PHARMACOLOGY & PHARMACY Alcohol Pub Date : 2023-12-01 DOI:10.1016/j.alcohol.2023.11.009
Ayman El-Menyar , Ahammed Mekkodathil , Rafael Consunji , Aisha Abeid , Rifat Latifi , Sandro Rizoli , Hassan Al-Thani
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引用次数: 0

摘要

背景:酒精消费是几种类型的伤害和创伤累犯的重要危险因素,并且仍然是世界范围内重要的公共卫生问题。我们的目的是描述在一个部分禁止饮酒的国家的一级创伤中心收治的创伤患者中强制性酒精筛查和审计工具的实施情况。方法:回顾性分析2014年至2019年期间需要住院并接受血液酒精浓度(BAC)筛查的创伤患者(>12岁)。这是通过使用乙醇脱氢酶在血浆和血清样品中检测乙醇的酶促方法实现的。创伤患者BAC < 2.2 mmol/L为“阴性”,BAC > 2.2 mmol/L为“阳性”。对两组BAC进行比较分析。采用酒精筛查、短暂干预、转诊治疗(ASBIRT)方案和审计。结果:在研究期间,7284例患者共进行了7326次BAC筛查试验。多年间差异较小,符合率为77%(70.4% ~ 85.3%),检测阳性率为10%(8.6% ~ 12.5%)。42例患者重复入院,其中7例患者每次入院时BAC阳性。年轻和非阿拉伯患者更有可能检测出阳性,而损伤(MOI)的主要机制是道路交通相关的创伤(p结论:尽管多年来创伤入院的BAC筛查有所改善,但仍有近20%的病例被遗漏。尽管死亡率是相似的,但酒精消费在过度影像、插管、腹部直视手术和可能的残疾方面给资源带来了负担。需要进一步的研究来了解在创伤环境中实现最佳依从性筛查的主要障碍和挑战。
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Implementation of mandatory blood alcohol screening in trauma patients: A retrospective study from a tertiary trauma center in a Middle Eastern country

Background

Alcohol consumption is a significant risk factor for several types of injuries and trauma recidivism and remains an important public health concern worldwide. We aimed to describe the implementation of mandatory alcohol screening and the AUDIT tool among trauma patients admitted to a level 1 trauma center in a country with a partial ban on alcohol consumption.

Methods

This was a retrospective analysis of trauma patients (>12 years old) who required hospital admission and underwent blood alcohol concentration (BAC) screening between 2014 and 2019. This was achieved via an enzymatic method using alcohol dehydrogenase for ethanol detection in the plasma and serum samples. Trauma patients with a BAC <2.2 mmol/L were referred to as “negative”, and BAC >2.2 mmol/L was referred to as “BAC positive”. A comparative analysis was performed between the two BAC groups. Alcohol Screening, Brief Intervention, Referral for Treatment [ASBIRT] program, and AUDIT were applied.

Results

A total of 7326 BAC screening tests were performed on 7284 patients during the study period. With slight variation over the years, the compliance rate was 77% (70.4%–85.3%), and the test positivity rate was 10% (8.6%–12.5%). There were 42 repeated admissions, of which seven patients were BAC positive at every admission. Young age and non-Arab patients were more likely to test positive, and the main mechanism of injury (MOI) was road traffic-related trauma (p < 0.05). Assault and self-inflicted injuries were significantly higher in BAC-positive patients than in BAC-negative patients (18% vs. 4% and 2.7% vs. 1.3%, respectively; p = 0.001). The injury severity score (ISS) and mortality rate were comparable between the study groups. Patients with a positive BAC were significantly more likely to undergo pan-CT scan in the emergency department, intubation, and exploratory laparotomy than those with a negative BAC. In patients who sustained injuries due to assault, all-terrain vehicles, or motorcycle crashes, there was a significant association between the positivity of BAC tests and the patient's ISS.

Conclusion

Despite improvements in BAC screening in trauma admissions over the years, almost 20% of cases were missed. Although the mortality rates were comparable, alcohol consumption burdens resources in terms of excess imaging, intubation, open abdominal surgery, and possible disability. Further studies are needed to understand the key obstacles and challenges to achieving optimum compliance for screening in trauma settings.

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来源期刊
Alcohol
Alcohol 医学-毒理学
CiteScore
4.60
自引率
4.30%
发文量
74
审稿时长
15.6 weeks
期刊介绍: Alcohol is an international, peer-reviewed journal that is devoted to publishing multi-disciplinary biomedical research on all aspects of the actions or effects of alcohol on the nervous system or on other organ systems. Emphasis is given to studies into the causes and consequences of alcohol abuse and alcoholism, and biomedical aspects of diagnosis, etiology, treatment or prevention of alcohol-related health effects. Intended for both research scientists and practicing clinicians, the journal publishes original research on the neurobiological, neurobehavioral, and pathophysiological processes associated with alcohol drinking, alcohol abuse, alcohol-seeking behavior, tolerance, dependence, withdrawal, protracted abstinence, and relapse. In addition, the journal reports studies on the effects alcohol on brain mechanisms of neuroplasticity over the life span, biological factors associated with adolescent alcohol abuse, pharmacotherapeutic strategies in the treatment of alcoholism, biological and biochemical markers of alcohol abuse and alcoholism, pathological effects of uncontrolled drinking, biomedical and molecular factors in the effects on liver, immune system, and other organ systems, and biomedical aspects of fetal alcohol spectrum disorder including mechanisms of damage, diagnosis and early detection, treatment, and prevention. Articles are published from all levels of biomedical inquiry, including the following: molecular and cellular studies of alcohol''s actions in vitro and in vivo; animal model studies of genetic, pharmacological, behavioral, developmental or pathophysiological aspects of alcohol; human studies of genetic, behavioral, cognitive, neuroimaging, or pathological aspects of alcohol drinking; clinical studies of diagnosis (including dual diagnosis), treatment, prevention, and epidemiology. The journal will publish 9 issues per year; the accepted abbreviation for Alcohol for bibliographic citation is Alcohol.
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