Irene Pi-Martín, Alejandro Cebrecos, Juan J. García-Garrigós, Noé Jiménez, Francisco Camarena
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Spatial resolution and reconstructed size accuracy using advanced beamformers in linear array-based PAT systems
Limitations associated with linear-array probes in photoacoustic tomography are partially compensated by using advanced beamformers that exploit the temporal and spatial coherence of the recorded signals, such as Delay Multiply and Sum (DMAS), Minimum Variance (MV) or coherence factor (CF), among others. However, their associated signal processing leads to an overestimation of the spatial resolution, as well as alterations in the reconstructed object size. Numerical and experimental results reported here support this hypothesis. First, we show that the Rayleigh criterion (RC) is the most suitable choice to characterize the spatial resolution instead of the Point Spread Function (PSF) when considering advanced beamformers. Then, we observe that several advanced beamformers fail to properly reconstruct target sizes slightly above the spatial resolution, underestimating their size. This work sheds light on the suitability of this type of beamformers combined with linear probes for determining sizes and morphology in photoacoustic images.
PhotoacousticsPhysics and Astronomy-Atomic and Molecular Physics, and Optics
CiteScore
11.40
自引率
16.50%
发文量
96
审稿时长
53 days
期刊介绍:
The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms.
Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring.
Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed.
These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.