Synthesis of Hepta-arbutin-branched β-Cyclodextrins at Their Primary Sides

This paper describes the synthesis of β-cyclodextrin (CD) based arbutin (4-hydroxyphenyl β-glucopyanoside) conjugates as a model for drug delivery molecules. We introduced three variants of hepta-arbutin-branched CDs at their primary side. Of these, two incorporated oligo(ethylene)chains within their spacers to demonstrate the effect of varying spatial characteristics between the β-glucopyanoside moieties. Due to the sterically hindered position on the primary side of β-CD, we employed a highly efficient click chemistry reaction.