多糖是治疗脊髓损伤的前景广阔的平台:综述

IF 10.7 1区 化学 Q1 CHEMISTRY, APPLIED Carbohydrate Polymers Pub Date : 2023-12-09 DOI:10.1016/j.carbpol.2023.121672
Yuanli Yang , Rangrang Fan , Hui Li , Haifeng Chen , Hanlin Gong , Gang Guo
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引用次数: 0

摘要

脊髓损伤是一种无法治愈的疾病,通常会对运动功能和自主感觉能力造成不可逆的损害。为了提高细胞、生长因子、药物和核酸等治疗物质治疗脊髓损伤的效果,同时减少化学试剂的毒副作用,多糖因其免疫调节特性以及多糖支架的生物相容性和生物可降解性而备受关注。多糖具有作为药物输送系统治疗脊髓损伤的潜力。本文旨在对过去五年中多糖材料在支架构建、给药和免疫调节方面的潜在应用进行广泛评估,从而为脊髓损伤的治疗提供新的方向和机遇。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Polysaccharides as a promising platform for the treatment of spinal cord injury: A review

Spinal cord injury is incurable and often results in irreversible damage to motor function and autonomic sensory abilities. To enhance the effectiveness of therapeutic substances such as cells, growth factors, drugs, and nucleic acids for treating spinal cord injuries, as well as to reduce the toxic side effects of chemical reagents, polysaccharides have been gained attention due to their immunomodulatory properties and the biocompatibility and biodegradability of polysaccharide scaffolds. Polysaccharides hold potential as drug delivery systems in treating spinal cord injuries. This article aims to present an extensive evaluation of the potential applications of polysaccharide materials in scaffold construction, drug delivery, and immunomodulation over the past five years so that offering new directions and opportunities for the treatment of spinal cord injuries.

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来源期刊
Carbohydrate Polymers
Carbohydrate Polymers 化学-高分子科学
CiteScore
22.40
自引率
8.00%
发文量
1286
审稿时长
47 days
期刊介绍: Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.
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