通过贻贝模拟多巴胺与非抗生素溶菌酶和甲状旁腺激素改善锌合金的抗革兰氏阳性菌性能和成骨作用

IF 1.6 Q4 ENGINEERING, BIOMEDICAL Biosurface and Biotribology Pub Date : 2023-12-04 DOI:10.1049/bsb2.12072
Deren Zhao, Tianhao Chen, Jinqian Chen, Banglun Huang, Jihua Nie, Hulin Liu, Yangkai Liu, Zilin Chen, Feng Zou, Qiqi Lu, Xiaodong Tan, Yunjie Xiang, Jing Li, Yongping Zhang, Xue Feng, X. Rao
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引用次数: 0

摘要

本研究利用含溶菌酶(LYS)和甲状旁腺激素(PTH)的仿贻贝聚多巴胺(PDA)在锌铝合金(ZA6‐1)表面制备了一种具有抑制革兰氏阳性细菌和促进成骨作用的非抗生素涂层。结果表明,as -沉积涂层能有效地将ZA6 - 1的降解速率从0.52 mm/年降低到0.16 mm/年,LYS的加入降低了涂层的耐蚀性,PTH的加入提高了涂层的耐蚀性。尽管对大肠杆菌没有明显的抑制作用,但包覆锌合金对金黄色葡萄球菌有良好的体外抗菌性能。与ZA6‐1锌合金相比,抗菌效果提高86.9% ~ 90.1%。此外,PDA‐LYS/PTH涂层样品具有较低的亲水性(26.4°)、较高的成骨细胞活力(>100%)、良好的成骨细胞形态和较好的成骨细胞分化(ALP = 107.7%),表明该涂层有望用于修饰可生物降解的锌植入物。
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Improving anti‐Gram‐positive‐bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non‐antibiotic lysozyme and parathyroid hormone
In this work, a novel coating with a non‐antibiotic agent for inhibiting Gram‐positive bacteria and promoting osteogenesis was prepared on zinc‐aluminium alloy (ZA6‐1) via mussel mimetic polydopamine (PDA) containing lysozyme (LYS) and parathyroid hormone (PTH). The results indicate that as‐deposited coatings can efficiently decrease the degradation rate of ZA6‐1 from 0.52 to 0.16 mm/year, and the addition of LYS weakens the coating resistance, while the addition of PTH enhances the coating resistance. In spite that no obvious inhibition of Escherichia coli is observed, the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus. Compared with ZA6‐1 zinc alloys, the increase of antibacterial efficacy reaches 86.9%–90.1%. Furthermore, the lower hydrophilicity (26.4°), higher osteoblast cell viability (>100%), good osteoblast cell morphology and better osteoblast cell differentiation (ALP = 107.7%) for PDA‐LYS/PTH coated samples support that as‐prepared coating is promising for modifying biodegradable zinc implants.
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来源期刊
Biosurface and Biotribology
Biosurface and Biotribology Engineering-Mechanical Engineering
CiteScore
1.70
自引率
0.00%
发文量
27
审稿时长
11 weeks
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