Fisiopatologia da COVID-19 e da síndrome inflamatória multissistêmica na criança: Revisão de escopo

years since the first cases, the knowledge about the virus is yet very scarce. Despite that, based on the differences between the clinical course and the prevalence of the disease among children and adults, it is possible to imply that may be some distinct physiopathology mechanisms between these two groups. Objective: The aim is to present scientific evidence concerning the pathophysiology of COVID-19 and the Multisystem Inflammatory Syndrome in Children (MIS-C). Methodology: Scope review based on the descriptors Coronavirus and/or COVID-19, Multisystem Inflammatory Syndrome in Children and/or MIS-C, Pathophysiology and Children and their correspondents in English and Spanish, carried out in the SciELO, MEDLINE databases, BVS-LILACS and PUBCOVID19, following the proposal of the Joanna Briggs Institute, in five stages. Results: This rewiew included 28 studies published in many countries between 2020 and 2021. Conclusions: Differences in the immune and respiratory systems and receptors ECA2 that seem to be related to lower severity of COVID-19 in children were presented. Also, different immunological patterns and the involvement of other systems, like the gastrointestinal tract, had also been identified in pediatric patients who develop MIS-C.