Some histological effects of Bisphenol-A on some reproductive organs in male adult rabbits (Oryctolagus cuniculus)

Bisphenol-A (BPA) is a broadly used substance in our environment. The current study was established to investigate the potentially toxic effects of BPA in the histology of adult male albino rabbits' reproductive organs. 45 adult male rabbits were subdivided into three groups. Group 1 orally received standard saline solution daily (proposed as a negative control); Group 2 received (0.5 ml/day) of olive oil orally daily (offered as a positive control); and the third Group, 3 rabbits, were treated orally with a dose of 25mg\Kg BW of the BP-A which dissolved in olive oil for 30 days. Tissue specimens from epididymis, testis, seminal vesicles and prostate were collected for histological examination. Blood samples were collected for serum hormone level evaluation. Results showed that BPA caused a significant decrease in testosterone, Luteinizing hormone, Follicle stimulating hormone, and a significant increase in estradiol and prolactin, along with some histopathological alterations in the epithelial and connective tissues of all the organs of studied animals. In conclusion, BPA induced hormonal disturbances in some hormones of the reproductive pituitary axis and histologic and toxic effects on the histology of all reproductive organs. Keywords: Bis-Phenol A; reproductive hormones; testis; epididymis; accessory sex glands; histology.