Qian Wang, Ruize Yin, Zihan Wang, Yanbin Zhang, Jie Wu
{"title":"停流微管反应器系统在有机反应开发中的应用","authors":"Qian Wang, Ruize Yin, Zihan Wang, Yanbin Zhang, Jie Wu","doi":"10.1007/s41981-023-00302-z","DOIUrl":null,"url":null,"abstract":"<div><p>Recently demonstrated as a novel reaction screening technology, the stop-flow micro-tubing (SFMT) reactors amalgamate features from continuous micro-flow and conventional batch reactors, resulting in a more logical and rigorous synthesis approach. When compared to traditional batch reactors, SFMT provides a safer and more efficient alternative, particularly suitable for chemical reactions under drastic conditions. The incorporation of commercially available transparent micro-tubing into SFMT makes it an excellent choice for light-mediated reactions, ensuring more uniform exposure to light. And SFMT stands apart from continuous-flow reactors by offering a notably convenient screening approach that is unrestricted by residence time and reactor size, while also effectively eradicating the risk of cross-contamination. The successful reactions developed within the SFMT reactor can be easily translated to continuous-flow synthesis for large-scale production. Overall, the SFMT reactor system exhibits similarities to continuous-flow reactors while surpassing batch reactors, especially for reactions involving gas reagents and/or requiring light illumination. This review aims to provide a comprehensive survey of the synthetic application of SFMT.</p></div>","PeriodicalId":630,"journal":{"name":"Journal of Flow Chemistry","volume":"14 1","pages":"97 - 107"},"PeriodicalIF":2.0000,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of stop-flow micro-tubing reactor system in organic reaction development\",\"authors\":\"Qian Wang, Ruize Yin, Zihan Wang, Yanbin Zhang, Jie Wu\",\"doi\":\"10.1007/s41981-023-00302-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Recently demonstrated as a novel reaction screening technology, the stop-flow micro-tubing (SFMT) reactors amalgamate features from continuous micro-flow and conventional batch reactors, resulting in a more logical and rigorous synthesis approach. When compared to traditional batch reactors, SFMT provides a safer and more efficient alternative, particularly suitable for chemical reactions under drastic conditions. The incorporation of commercially available transparent micro-tubing into SFMT makes it an excellent choice for light-mediated reactions, ensuring more uniform exposure to light. And SFMT stands apart from continuous-flow reactors by offering a notably convenient screening approach that is unrestricted by residence time and reactor size, while also effectively eradicating the risk of cross-contamination. The successful reactions developed within the SFMT reactor can be easily translated to continuous-flow synthesis for large-scale production. Overall, the SFMT reactor system exhibits similarities to continuous-flow reactors while surpassing batch reactors, especially for reactions involving gas reagents and/or requiring light illumination. This review aims to provide a comprehensive survey of the synthetic application of SFMT.</p></div>\",\"PeriodicalId\":630,\"journal\":{\"name\":\"Journal of Flow Chemistry\",\"volume\":\"14 1\",\"pages\":\"97 - 107\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2023-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Flow Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s41981-023-00302-z\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Flow Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s41981-023-00302-z","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Application of stop-flow micro-tubing reactor system in organic reaction development
Recently demonstrated as a novel reaction screening technology, the stop-flow micro-tubing (SFMT) reactors amalgamate features from continuous micro-flow and conventional batch reactors, resulting in a more logical and rigorous synthesis approach. When compared to traditional batch reactors, SFMT provides a safer and more efficient alternative, particularly suitable for chemical reactions under drastic conditions. The incorporation of commercially available transparent micro-tubing into SFMT makes it an excellent choice for light-mediated reactions, ensuring more uniform exposure to light. And SFMT stands apart from continuous-flow reactors by offering a notably convenient screening approach that is unrestricted by residence time and reactor size, while also effectively eradicating the risk of cross-contamination. The successful reactions developed within the SFMT reactor can be easily translated to continuous-flow synthesis for large-scale production. Overall, the SFMT reactor system exhibits similarities to continuous-flow reactors while surpassing batch reactors, especially for reactions involving gas reagents and/or requiring light illumination. This review aims to provide a comprehensive survey of the synthetic application of SFMT.
期刊介绍:
The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.