停流微管反应器系统在有机反应开发中的应用

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Flow Chemistry Pub Date : 2023-12-28 DOI:10.1007/s41981-023-00302-z
Qian Wang, Ruize Yin, Zihan Wang, Yanbin Zhang, Jie Wu
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引用次数: 0

摘要

作为一种新颖的反应筛选技术,止流微管反应器(SFMT)最近得到了证实,它融合了连续微流反应器和传统间歇反应器的特点,从而产生了一种更合理、更严格的合成方法。与传统的间歇式反应器相比,SFMT 提供了一种更安全、更高效的替代方案,尤其适用于激烈条件下的化学反应。SFMT 中采用了市场上可买到的透明微管,使其成为光介导反应的绝佳选择,确保了更均匀的光照射。SFMT 不受停留时间和反应器大小的限制,是一种非常方便的筛选方法,同时还能有效消除交叉污染的风险,因而有别于连续流反应器。在 SFMT 反应器中开发的成功反应可以很容易地转化为大规模生产所需的连续流合成。总体而言,SFMT 反应器系统与连续流反应器相似,但又优于间歇式反应器,尤其是在涉及气体试剂和/或需要光照的反应方面。本综述旨在全面介绍 SFMT 的合成应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Application of stop-flow micro-tubing reactor system in organic reaction development

Recently demonstrated as a novel reaction screening technology, the stop-flow micro-tubing (SFMT) reactors amalgamate features from continuous micro-flow and conventional batch reactors, resulting in a more logical and rigorous synthesis approach. When compared to traditional batch reactors, SFMT provides a safer and more efficient alternative, particularly suitable for chemical reactions under drastic conditions. The incorporation of commercially available transparent micro-tubing into SFMT makes it an excellent choice for light-mediated reactions, ensuring more uniform exposure to light. And SFMT stands apart from continuous-flow reactors by offering a notably convenient screening approach that is unrestricted by residence time and reactor size, while also effectively eradicating the risk of cross-contamination. The successful reactions developed within the SFMT reactor can be easily translated to continuous-flow synthesis for large-scale production. Overall, the SFMT reactor system exhibits similarities to continuous-flow reactors while surpassing batch reactors, especially for reactions involving gas reagents and/or requiring light illumination. This review aims to provide a comprehensive survey of the synthetic application of SFMT.

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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
期刊最新文献
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