一名甲状旁腺癌患者的垂体窝被从蝶骨中长出的巨大骨细胞瘤侵袭导致垂体功能减退症

IF 0.9 Q4 ENDOCRINOLOGY & METABOLISM Case Reports in Endocrinology Pub Date : 2023-12-21 eCollection Date: 2023-01-01 DOI:10.1155/2023/8274108
Leonardo Bandeira, Lucian Batista de Oliveira, Maria Vitória Silva de Lima, Daniella Rêgo, Luiz Griz, Francisco Bandeira
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引用次数: 0

摘要

背景:病例报告:甲状旁腺癌占甲状旁腺疾病的大多数。一名 47 岁的女性患者曾被诊断为 PHPT,6 年前接受了甲状旁腺切除术,组织学检查显示其患有甲状旁腺腺瘤。术后,她的血清甲状旁腺激素(PTH)和血钙水平持续偏高,并出现骨痛和自发性骨折。影像学检查显示,蝶骨上有一个巨大的破骨细胞瘤,侵犯了垂体窝,导致垂体功能减退。患者接受了新的甲状旁腺切除术,组织学确诊为甲状旁腺癌,破骨细胞瘤也已消退:本病例说明了甲状旁腺癌的一种不寻常表现,即蝶骨的破骨细胞瘤导致垂体功能减退。
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Hypopituitarism due to a Large Osteoclastoma Arising from the Sphenoid Bone Invading the Pituitary Fossa in a Patient with Parathyroid Carcinoma.

Background: Parathyroid carcinoma accounts for <1% of cases of primary hyperparathyroidism (PHPT). This rare condition may present with severe hypercalcemia and bone complications such as osteoclastomas and pathologic fractures. Here, we present a rare condition of panhypopituitarism resulting from an osteoclastoma in the sphenoid bone that invaded the pituitary fossa due to parathyroid carcinoma. Case Report. A 47-year-old woman previously diagnosed with PHPT underwent a parathyroidectomy 6 years earlier, with histological examination indicating a parathyroid adenoma. After surgery, she continued to exhibit high serum parathyroid hormone (PTH) and calcium levels, with the development of bone pain and spontaneous fractures. Imaging exams showed a large osteoclastoma of the sphenoid bone, invading the pituitary fossa, causing hypopituitarism. A new parathyroidectomy was performed, with histological confirmation of parathyroid carcinoma and regression of the osteoclastoma.

Conclusion: This case illustrates an unusual presentation of parathyroid carcinoma, in which an osteoclastoma of the sphenoid bone caused hypopituitarism.

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来源期刊
Case Reports in Endocrinology
Case Reports in Endocrinology ENDOCRINOLOGY & METABOLISM-
CiteScore
2.10
自引率
0.00%
发文量
45
审稿时长
13 weeks
期刊最新文献
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