Inside Front Cover: Portable non-enzymatic electrochemical biosensor based on caffeine for Alzheimer's disease diagnosis (View 6/2023)

In article number 20230052, Jieling Qin, Zhenqi Jiang and their co-workers have described caffeine as a biorecognition element to detect amyloid beta 1-42 (Aβ1-42), a biomarker of Alzheimer's disease. In this cover, caffeine was bound to a gold electrode modified with pine polythiophene-3-acetic acid and recognized Aβ1-42 by intermolecular forces. This strategy demonstrates good detection performance in real sample analysis and enables the development of portable instruments to achieve rapid detection of Aβ1-42, suggesting the potential for practical applications.