镉会诱发高血压大鼠小红细胞增多症和无细胞增多症,但不会导致贫血。

IF 4.1 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biometals Pub Date : 2024-01-07 DOI:10.1007/s10534-023-00567-w
Garsha McCalla, Paul D. Brown, Chukwuemeka Nwokocha
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引用次数: 0

摘要

膳食镉(Cd2+)摄入量与高血压和贫血的发病机制有关,但有关高血压情况下血液学变化的信息却很少。因此,本研究旨在评估 Cd2+ 对 Sprague-Dawley 大鼠模型血压和血液学指标的影响。研究选取了三组(每组 10 只)对照组和喂食 Cd2+ 的雄性 Sprague-Dawley 大鼠。暴露于 Cd2+ 的大鼠每周三次通过灌胃接受 2.5 或 5 毫克/千克体重的氯化镉,为期八周,而对照组动物则接受自来水。每周两次使用 CODA 机从大鼠尾部无创测量血压和血流量,每周三次测量体重。血液指标使用 Cell-Dyn Emerald 血液分析仪进行评估。数据以平均值 ± SEM 表示,并采用单向方差分析进行统计分析。多重比较采用 Bonferroni 事后检验。镉2+暴露诱导的高血压显著(p 2+)。血红蛋白浓度(MCHC)、血细胞比容、血红蛋白、红细胞、血小板、平均血小板体积和白细胞计数不受 Cd2+ 暴露的影响。Cd2+ 可诱发高血压、小红细胞增多症、低色素性和异形细胞增多症,但不会导致贫血,这可能是小红细胞性贫血和冠状动脉疾病的前兆。这项研究在镉2+暴露的环境中非常重要,值得进一步研究。
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Cadmium induces microcytosis and anisocytosis without anaemia in hypertensive rats

Dietary cadmium (Cd2+) intake is implicated in the pathogenesis of hypertension and anaemia, but there is a paucity of information on the haematological changes in hypertensive conditions. This study, therefore, aims to evaluate the effects of Cd2+ on blood pressure (BP) and haematological indices in the Sprague–Dawley rat model. Three cohorts (n = 10 each) of control and Cd2+-fed male Sprague–Dawley rats were selected. Cd2+-exposed rats received 2.5 or 5 mg/kg b.w. cadmium chloride via gavage thrice-weekly for eight weeks, while control animals received tap water. BP and flow were measured non-invasively from rat tails twice-weekly using a CODA machine, while weights were measured thrice-weekly. Haematological indices were assessed using the Cell-Dyn Emerald Haematology Analyzer. Data were reported as mean ± SEM, and statistically analyzed using One-Way Analysis of Variance. Bonferroni post hoc test was used for multiple comparisons. Cd2+-exposure induced hypertension by significantly (p < 0.05) elevating systolic, diastolic, and mean arterial BPs, pulse pressure, and heart rate (HR), and increased (p < 0.05) blood flow. Mean cell volume (MCV) and haemoglobin (MCH) were significantly (p < 0.05) reduced, and red cell distribution width (RDW) significantly (p < 0.01) increased by exposure to 5 mg/kg b.w. Cd2+. Haemoglobin concentration (MCHC), haematocrit, haemoglobin, red blood cell, platelet, mean platelet volume, and white blood cell counts were unaffected by Cd2+-exposure. Cd2+ induced hypertension, microcytosis, hypochromicity, and anisocytosis without anaemia, which may be precursor to microcytic anaemia and coronary artery disease. This study is important in Cd2+-exposed environments and warrants further investigations.

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来源期刊
Biometals
Biometals 生物-生化与分子生物学
CiteScore
5.90
自引率
8.60%
发文量
111
审稿时长
3 months
期刊介绍: BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of: - metal ions - metal chelates, - siderophores, - metal-containing proteins - biominerals in all biosystems. - BioMetals rapidly publishes original articles and reviews. BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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