Functional condition of the skin in women with metabolic syndrome

It is known that in people with metabolic diseases, reparation processes are disturbed during surgical interventions. However, the functional state of the skin during the development of the metabolic syndrome has been little studied. The aim of the work was to investigate the functional state of the skin in women with metabolic syndrome. Materials and methods. The study included 60 women aged 39 to 55 who sought surgical care for cosmetic skin defects. The control group consisted of 30 practically healthy women. Signs of metabolic syndrome were registered in 30 women who were included in the main group. The rate of reproduction of basal keratinocytes was determined according to the method of P. V. Kozhevnikova. The neutralizing ability of the skin was determined by the colorimetric method according to the time of disappearance of the bright crimson color (in minutes). The elastometric indicators of the skin were studied by the vacuum aspiration method using an applied cuvette with a diameter of 20 mm at a negative pressure of 20 kPa. The results. It was found that in women with metabolic syndrome, the duration of exfoliation of the stratum corneum increased by 48.1% (p < 0.01) compared to controls. This indicates a decrease in the rate of division of basal epidermocytes in the case of the development of metabolic syndrome. In the main group, the neutralization of the irritating agent was slower by 24.1% (p < 0.01), which indicates a decrease in the reactogenic properties of the skin in people with signs of metabolic syndrome. In patients with metabolic syndrome, the elastometric index of the skin increased by 46.0% (p < 0.001), which indicates changes in the tinctorial properties of the skin associated with the metabolic destruction of collagen. Conclusion. Significant changes in the functional state of the skin were registered in women with metabolic syndrome compared to healthy women: the rate of division of basal keratinocytes decreased, the elasticity of the skin deteriorated, and the index of its reactogenicity decreased. The identified changes, to a certain extent, explain the reasons for the violation of reparative processes in the skin after surgical interventions. Key words: metabolic syndrome, exfoliation of the stratum corneum of the skin, rate of division of basal keratinocytes, skin elasticity.