根据解剖学原理安装人工耳蜗有意义吗?我们在第一批患者身上获得的经验

Luis Lassaletta, M. Calvino, Isabel Sánchez-Cuadrado, Javier Gavilán
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摘要

个性化治疗是各个医学领域日益增长的趋势,其中也包括人工耳蜗植入术。精确选择电极阵列的长度和形状以适应特定的耳蜗解剖结构,以及个性化的适配设置都被认为可以改善人工耳蜗植入(CI)的听力效果。本研究的目的是比较基于解剖学的验配(ABF)与默认验配在频率-位置不匹配、言语辨别力和 MED-EL CI 用户主观效果方面的差异。使用 Otoplan 软件计算了每个电极的植入深度和声调分布。计算出每种适配策略相对于电极声调定位频率的不匹配度。使用 ABF 和默认配戴分别 9 个月和 1 个月后,对语音测试和患者偏好进行了评估。最顶端有效电极的插入角度中位数为 594°(四分位间范围为 143°)。在所有患者中,ABF 的不匹配度均低于默认拟合(p ≤ 0.01)。使用 ABF 和默认拟合的平均语音辨别率分别为 73 ± 11% 和 72 ± 16%(p = 0.672)。使用 ABF 和默认拟合的平均语音接收阈值分别为 3.6 ± 3.4 dB 和 4.2 ± 5.0 dB(p = 0.401)。与默认拟合地图相比,ABF 地图的频率-位置错配率更低。尽管听力结果相似,但大多数患者更倾向于 ABF。需要更多的数据来证实 ABF 在言语和主观测试中优于默认验配。
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Does it make any sense to fit cochlear implants according to the anatomy-based fitting? Our experience with the first series of patients
Personalization of treatment is a growing trend in various fields of medicine, and this includes cochlear implantation. Both the precise choice of the length and shape of the electrode array to fit a particular cochlear anatomy, as well as an individualized fitting setting have been suggested to improve hearing outcomes with a cochlear implant (CI). The aim of this study was to compare anatomy-based fitting (ABF) vs. default fitting in terms of frequency-to-place mismatch, speech discrimination, and subjective outcomes in MED-EL CI users.Eight adult CI users implanted with a Synchrony ST Flex28 were enrolled prospectively. Insertion depth and tonotopic distribution of each electrode was calculated using the Otoplan software. The mismatch was calculated for each fitting strategy relative to the electrodes' tonotopic place-frequency. Speech tests and patient preference was evaluated after 9 months with ABF and 1 month after default fitting.Median angular insertion of the most apical active electrode was 594° (interquartile range 143°). ABF showed lower mismatches than default fitting in all patients (p ≤ 0.01). Mean speech discrimination score with ABF and default fitting was 73 ± 11% and 72 ± 16%, respectively (p = 0.672). Mean speech reception threshold with ABF and default fitting was 3.6 ± 3.4 dB and 4.2 ± 5.0 dB, respectively (p = 0.401). All patients except one preferred ABF when they were asked about their preference.ABF maps have a lower frequency-to-place mismatch than default fitting maps. In spite of similar hearing outcomes most patients prefer ABF. More data are necessary to corroborate the benefit of the ABF over default fitting in speech and subjective tests.
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