新型 CYP17A1 抑制剂 alsevirone 的抗增殖活性

Russian Journal of Oncology Pub Date : 2023-11-07 DOI:10.17816/onco492271

I. I. Khan, A. S. Latysheva, V. A. Zolottsev, Elena A. Demidova, Tatyana S. Spirina, Saida S. Karshieva, D. Sokolova, M. N. Yakunina, A. Misharin, Marina V. Komarova, V. Pokrovsky

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摘要

摘要背景：在发达国家，前列腺癌（PC）是最常见的男性癌症类型。前列腺癌对雄激素有依赖性，因此可以通过雄激素剥夺疗法来有效防治前列腺癌。减少雄激素的合成可通过抑制 17-羟色胺酶来实现。

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Antiproliferative activity of the novel CYP17A1 inhibitor alsevirone

Abstract Background: Prostate cancer (PC) is the most frequently diagnosed type of cancer in men in developed countries. PC is dependent upon androgens and could be effectively combated by androgen deprivation therapy in such patients. Reduction of androgen synthesis can be accomplished through the inhibition of the enzyme 17

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Russian Journal of Oncology

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