Getting to grips with resilience: Toward large-scale phenotyping of this complex trait*

The capacity of animals to cope with environmental perturbations, hereafter called resilience, is an increasingly important trait. Resilience at the level of the animal is an emergent property of multiple underlying mechanisms (physiological, immunological, behavioral). This means that there is no direct measure of resilience, no easy key traits. Resilience is a latent variable that may be inferred from multivariate measures. Further, the flexibility that resilience provides is evidenced in the rate of response to, and rate of recovery from, the environmental perturbation. Thus, it requires time-series measurements. The increasing availability of on-farm precision livestock technologies, which are capable of providing time-series measures of performance and of various physiological and health biomarkers, offer the opportunity to move toward large-scale phenotyping of resilience. There have been numerous studies putting forward methods to quantify resilience. These methods can be classified as being data driven or concept driven. However, new candidate resilience proxies need to be validated. This is tricky to do because there is no direct measure of resilience, no easy gold standard measure. Per definition, good resilience will benefit the animal. Thus, the accumulated consequences of resilience can be used to evaluate resilience proxies. All other things being equal, it is expected that good resilience will be associated with a longer functional longevity (longevity adjusted for production level), with more reproductive cycles, and with fewer disease events. Recent examples of this approach of evaluating resilience proxies against the accumulated consequences of resilience are discussed. They show clearly that operational resilience proxies that are heritable and have been validated against the consequences of good resilience can be derived from on-farm time-series data. With the aim of deriving more nuanced phenotypes, there are an increasing number of studies that have taken up the challenge of attempting to statistically combine the information coming from multiple time-series measures. These studies show how multivariate time-series statistics can be used to derive more nuanced resilience phenotypes that capture some of the underlying mechanisms of resilience. In conclusion, the recent studies reviewed here have shown that operational and heritable resilience proxies exist, that they can form the basis for selection for resilience, and that more nuanced phenotypes are attainable, which will allow selection for resilience to be tailored according to prevailing environmental challenge types.