{"title":"马来酸噻吗洛尔原位眼用粘胶-热敏凝胶：开发与表征","authors":"Sibel İLBASMIŞ TAMER, Özlem Çulcu, Eda Turan, Fahriye Figen Tirnaksiz","doi":"10.4274/tjps.galenos.2023.50723","DOIUrl":null,"url":null,"abstract":"Objectives: The purpose of this study was to prepare a sustained delivery mucoadhesive-thermosensitive formulation containing poloxamer 338 (P338), poloxamer 188 (P188) and mucoadhesive agents such as chitosan (CHT) and carboxymethylcellulose (CMC) to increase the ophthalmic bioavailability of Timolol Maleate (TM). Materials and Methods: Gels were prepared by mixing different amounts of P338, P188 and mucoadhesive agents in cold isotonic water with a magnetic stirrer. The sol-gel gelation time of the gels was determined using the test tube inversion method. Viscosity measurements and analysis of mechanical properties of gel formulations were carried out. In vitro release using dialysis membrane and ex vivo permeation studies using fresh cow eyes were performed.","PeriodicalId":23378,"journal":{"name":"Turkish Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Timolol Maleate In Situ Ophthalmic Mucoadhesive-Thermosensitive Gel: Development and Characterization\",\"authors\":\"Sibel İLBASMIŞ TAMER, Özlem Çulcu, Eda Turan, Fahriye Figen Tirnaksiz\",\"doi\":\"10.4274/tjps.galenos.2023.50723\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: The purpose of this study was to prepare a sustained delivery mucoadhesive-thermosensitive formulation containing poloxamer 338 (P338), poloxamer 188 (P188) and mucoadhesive agents such as chitosan (CHT) and carboxymethylcellulose (CMC) to increase the ophthalmic bioavailability of Timolol Maleate (TM). Materials and Methods: Gels were prepared by mixing different amounts of P338, P188 and mucoadhesive agents in cold isotonic water with a magnetic stirrer. The sol-gel gelation time of the gels was determined using the test tube inversion method. Viscosity measurements and analysis of mechanical properties of gel formulations were carried out. In vitro release using dialysis membrane and ex vivo permeation studies using fresh cow eyes were performed.\",\"PeriodicalId\":23378,\"journal\":{\"name\":\"Turkish Journal of Pharmaceutical Sciences\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2023-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Turkish Journal of Pharmaceutical Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4274/tjps.galenos.2023.50723\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Turkish Journal of Pharmaceutical Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/tjps.galenos.2023.50723","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Timolol Maleate In Situ Ophthalmic Mucoadhesive-Thermosensitive Gel: Development and Characterization
Objectives: The purpose of this study was to prepare a sustained delivery mucoadhesive-thermosensitive formulation containing poloxamer 338 (P338), poloxamer 188 (P188) and mucoadhesive agents such as chitosan (CHT) and carboxymethylcellulose (CMC) to increase the ophthalmic bioavailability of Timolol Maleate (TM). Materials and Methods: Gels were prepared by mixing different amounts of P338, P188 and mucoadhesive agents in cold isotonic water with a magnetic stirrer. The sol-gel gelation time of the gels was determined using the test tube inversion method. Viscosity measurements and analysis of mechanical properties of gel formulations were carried out. In vitro release using dialysis membrane and ex vivo permeation studies using fresh cow eyes were performed.
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