Use of platelet-rich fibrin in hypospadias surgery

Hypospadias is a common congenital anomaly. Treatment for hypospadias is surgical, but there is no technique that is recognized as the gold standard. The most common complication occurring after hypospadias repair is urethrocutaneous fistula with a reported incidence varying from 4% to 28%. The use of an intermediate layer between the neourethra and the skin is one of the most important techniques used to reduce the likelihood of fistula formation. Several coverage techniques have been described including local subcutaneous penile tissue, tunica vaginalis, dartos, and extragenital tissues. In addition to tissue flaps, fibrin sealants have been introduced to prevent fistula formation. Platelet-rich fibrin membrane is an autologous source of growth factors and has been used to prevent fistulous complications.