N-乙酰半胱氨酸可改善 5-氟尿嘧啶诱发的大鼠卵巢损伤

IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Clinical and Experimental Health Sciences Pub Date : 2023-07-05 DOI:10.33808/clinexphealthsci.1199615
Elif Ayazoglu Demir, A. Menteşe, Hatice Küçük, Nihal Türkmen, S. Demir, Y. Aliyazicioglu
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摘要

研究目的虽然5-氟尿嘧啶(5-FU)是世界上最常用的化疗药物之一,但近年来有研究表明,服用5-FU可导致生殖毒性。N-乙酰半胱氨酸(NAC)是谷胱甘肽的前体,谷胱甘肽是最重要的内源性抗氧化分子,因其有效的抗氧化和抗炎特性而闻名。虽然 NAC 是研究最多的抗氧化分子之一,但其对 5-FU 引起的卵巢损伤的治疗效果迄今尚未得到证实。因此,本研究旨在首次探讨 NAC 对 5-FU 引起的卵巢毒性是否有治疗作用。 研究方法首先让大鼠接触单剂量 5-FU(100 毫克/千克),然后用 NAC(10 毫克和 20 毫克/千克)治疗三天。采用分光光度法测定卵巢组织中的氧化应激、炎症和细胞凋亡指标。还对卵巢组织进行了组织学评估。 结果显示结果表明,服用 5-FU 后,卵巢组织中的氧化应激、炎症和细胞凋亡生物标志物水平升高(p
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N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats
Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time. Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p
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Clinical and Experimental Health Sciences
Clinical and Experimental Health Sciences MEDICINE, RESEARCH & EXPERIMENTAL-
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