通过自由基级联反应构建香豆素或 2-喹啉酮化合物的最新进展

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2024-01-05 DOI:10.2174/0118756298278048231205053801
Shuo Zhang, Wei Tang, Kai Zhou, Xiao-Xiao Huan, Zhi-Wei Chen
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引用次数: 0

摘要

:自由基反应在合成有机化学和药物化学中占有重要地位,极大地补充和扩展了香豆素或喹啉-2-酮化合物的合成。此外,与传统的贵金属催化或高温环化相比,利用 C3 位功能化构建香豆素或喹啉-2-酮化合物具有一定的优势,更符合绿色化学的主张。设计烯烃或炔烃作为级联反应的自由基受体,是获得香豆素或喹啉-2-酮分子的一种新颖而稳健的方法。在过去十年中,这些自由基级联环化反应得到了充分的探索和研究。因此,我们汇编了该领域快速发展的前沿研究综述,其中包括典型实例和对基本机理的深入探讨。
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Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions
: Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization, which is more in line with the advocates of green chemistry. The design of alkenes or alkynes as radical acceptors for cascade reactions presents a novel and robust approach to obtaining coumarin or quinolin-2-one molecules. These radical cascade cyclization reactions have been well explored and studied over the past decade. As a result, we have compiled a review of the rapidly developing cutting-edge research in this field, featuring typical examples and in-depth exploration of the underlying mechanisms.
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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