微生物组与小儿多发性硬化症(MS):系统综述。

IF 3.1 Q2 NEUROSCIENCES AIMS Neuroscience Pub Date : 2023-12-14 eCollection Date: 2023-01-01 DOI:10.3934/Neuroscience.2023031
Sanaz Mehrabani, Mohsen Rastkar, Narges Ebrahimi, Mahsa Ghajarzadeh
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引用次数: 0

摘要

背景:肠道微生物组在多发性硬化症(MS)等自身免疫性疾病的发病和调控中发挥作用。我们设计了这篇系统性综述,旨在总结肠道微生物群对小儿多发性硬化症发病影响的证据:两位独立研究人员对 PubMed、Scopus、EMBASE、Web of Science、Google Scholar、参考文献和会议摘要进行了全面检索。检索截止日期为 2023 年 1 月 1 日。提取的数据涉及患者总数、第一作者姓名、发表年份、原籍国、平均年龄、病程、体重指数(BMI)、多发性硬化症类型、残疾状况扩展量表(EDSS)、发病年龄和粪便成分:通过文献检索,共发现了 4237 项已发表的研究。去除重复内容后,我们有 2045 条记录可供评估。对 23 篇全文进行了评估,剩下 4 篇病例对照研究进行了系统性审查。三项研究在美国进行,一项在荷兰进行。纳入研究的参与者人数在 24 到 68 人之间。研究时患者的平均年龄介于 11.9 岁和 17.9 岁之间,发病时的平均年龄介于 11.5 岁和 14.3 岁之间。大多数患者为女性。结果表明,对照组的丰富度中位数(两项研究提供的已识别的独特分类群数量)高于病例组,一项研究报告的 Margalef 指数也高于病例组。两项研究结果还表明,对照组的均匀度指数(分类群分布、香农指数、辛普森指数)中位数以及 PD 指数(费斯系统多样性指标)均高于病例组:本系统综述(包括四项研究)的结果表明,儿科多发性硬化症病例的微生物群-免疫平衡被打破。
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Microbiomes and Pediatric onset multiple sclerosis (MS): A systematic review.

Background: Gut microbiomes play a role in developing and regulating autoimmune diseases such as multiple sclerosis (MS). We designed this systematic review to summarize the evidence of the effect of gut microbiota in developing pediatric-onset MS.

Methods: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, references of the references and conference abstracts were comprehensively searched by two independent researchers. The search was done on January 1st, 2023. Data regarding the total number of patients, the name of the first author, publication year, country of origin, mean age, duration of the disease, body mass index (BMI), type of MS, Expanded Disability Status Scale (EDSS), age at disease onset and stool composition were extracted.

Results: A literature search revealed 4237 published studies. After removing duplicates, we had 2045 records for evaluation. Twenty-three full texts were evaluated, and four case-control studies remained for systematic review. Three studies were conducted in the United States and one in the Netherlands. The number of participants in included studies ranged between 24 and 68. The mean age of patients at the time of study varied between 11.9 and 17.9 years, and the mean age at the onset of the disease ranged between 11.5 and 14.3 years. Most included patients were female. The results show that median richness (the number of unique taxa identified, which was provided by two studies) was higher in controls, and also Margalef index, which was reported by one study was higher in control group than the case group. The results of two studies also demonstrated that median evenness indexes (taxon distribution, Shannon, Simpson) were higher in control groups, as well as PD index (Faith's phylogenic diversity metric).

Conclusion: The result of this systematic review (including four studies) showed disruption of the microbiota-immune balance in pediatric-onset MS cases.

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来源期刊
AIMS Neuroscience
AIMS Neuroscience NEUROSCIENCES-
CiteScore
4.20
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: AIMS Neuroscience is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers from all areas in the field of neuroscience. The primary focus is to provide a forum in which to expedite the speed with which theoretical neuroscience progresses toward generating testable hypotheses. In the presence of current and developing technology that offers unprecedented access to functions of the nervous system at all levels, the journal is designed to serve the role of providing the widest variety of the best theoretical views leading to suggested studies. Single blind peer review is provided for all articles and commentaries.
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