腰背痛的未来:了解 IVD 成分和间充质干细胞的潜力。

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-01-16 DOI:10.1186/s13619-023-00184-5
Raquel Leão Monteiro
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引用次数: 0

摘要

腰背痛(LBP)主要源于椎间盘(IVD)退化。然而,人们对椎间盘纤维环(AF)和髓核(NP)等椎间盘成分导致椎间盘退变/疝的衰竭机制仍知之甚少。此外,与IVD疝相关的炎症过程中所涉及的细胞群和分子通路的具体作用仍有待强调。对疝形成初期相关炎症的了解有限,以及缺乏合适的模型来模拟人类 IVD 的复杂性是造成这种情况的部分原因。因此,有必要加强对炎症驱动变性过程中AF和NP细胞的细胞和分子关键角色的了解。间充质干细胞(MSCs)具有独特的免疫调节和多能特性,因此在骨和软骨再生领域获得了广泛认可。间充质干细胞疗法在促进受损组织的修复方面具有特别重要的价值,并可能有利于减轻炎症和退行性病变。因此,这篇综述文章进行了全面的研究,以进一步了解 IVD 成分的作用机制与间充质干细胞治疗潜力之间的相互关系,探讨间充质干细胞的特点、如何优化使用间充质干细胞并将其安全地应用于 LPB 治疗的不同环境中。
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Future of low back pain: unravelling IVD components and MSCs' potential.

Low back pain (LBP) mainly emerges from intervertebral disc (IVD) degeneration. However, the failing mechanism of IVD ́s components, like the annulus fibrosus (AF) and nucleus pulposus (NP), leading to IVD degeneration/herniation is still poorly understood. Moreover, the specific role of cellular populations and molecular pathways involved in the inflammatory process associated with IVD herniation remains to be highlighted. The limited knowledge of inflammation associated with the initial steps of herniation and the lack of suitable models to mimic human IVD ́s complexity are some of the reasons for that. It has become essential to enhance the knowledge of cellular and molecular key players for AF and NP cells during inflammatory-driven degeneration. Due to unique properties of immunomodulation and pluripotency, mesenchymal stem cells (MSCs) have attained diverse recognition in this field of bone and cartilage regeneration. MSCs therapy has been particularly valuable in facilitating repair of damaged tissues and may benefit in mitigating inflammation' degenerative events. Therefore, this review article conducts comprehensive research to further understand the intertwine between the mechanisms of action of IVD components and therapeutic potential of MSCs, exploring their characteristics, how to optimize their use and establish them safely in distinct settings for LPB treatment.

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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
期刊最新文献
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