{"title":"NeuroBus - 超灵活神经接口架构。","authors":"Markus Sporer;Ioana-Georgiana Vasilaş;Ahmed Adžemović;Nicolas Graber;Stefan Reich;Calogero Gueli;Max Eickenscheidt;Ilka Diester;Thomas Stieglitz;Maurits Ortmanns","doi":"10.1109/TBCAS.2024.3354785","DOIUrl":null,"url":null,"abstract":"This article presents the system architecture for an implant concept called \n<italic>NeuroBus</i>\n. Tiny distributed direct digitizing neural recorder ASICs on an ultra-flexible polyimide substrate are connected in a bus-like structure, allowing short connections between electrode and recording front-end with low wiring effort and high customizability. The small size (344\n<inline-formula><tex-math>$\\,\\mu$</tex-math></inline-formula>\nm × 294 \n<inline-formula><tex-math>$\\mu$</tex-math></inline-formula>\nm) of the ASICs and the ultraflexible substrate allow a low bending stiffness, enabling the implant to adapt to the curvature of the brain and achieving high structural biocompatibility. We introduce the architecture, the integrated building blocks, and the post-CMOS processes required to realize a \n<italic>NeuroBus</i>\n, and we characterize the prototyped direct digitizing neural recorder front-end as well as polyimide-based ECoG brain interface. A rodent animal model is further used to validate the joint capability of the recording front-end and thin-film electrode array.","PeriodicalId":94031,"journal":{"name":"IEEE transactions on biomedical circuits and systems","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10400847","citationCount":"0","resultStr":"{\"title\":\"NeuroBus - Architecture for an Ultra-Flexible Neural Interface\",\"authors\":\"Markus Sporer;Ioana-Georgiana Vasilaş;Ahmed Adžemović;Nicolas Graber;Stefan Reich;Calogero Gueli;Max Eickenscheidt;Ilka Diester;Thomas Stieglitz;Maurits Ortmanns\",\"doi\":\"10.1109/TBCAS.2024.3354785\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This article presents the system architecture for an implant concept called \\n<italic>NeuroBus</i>\\n. Tiny distributed direct digitizing neural recorder ASICs on an ultra-flexible polyimide substrate are connected in a bus-like structure, allowing short connections between electrode and recording front-end with low wiring effort and high customizability. The small size (344\\n<inline-formula><tex-math>$\\\\,\\\\mu$</tex-math></inline-formula>\\nm × 294 \\n<inline-formula><tex-math>$\\\\mu$</tex-math></inline-formula>\\nm) of the ASICs and the ultraflexible substrate allow a low bending stiffness, enabling the implant to adapt to the curvature of the brain and achieving high structural biocompatibility. We introduce the architecture, the integrated building blocks, and the post-CMOS processes required to realize a \\n<italic>NeuroBus</i>\\n, and we characterize the prototyped direct digitizing neural recorder front-end as well as polyimide-based ECoG brain interface. A rodent animal model is further used to validate the joint capability of the recording front-end and thin-film electrode array.\",\"PeriodicalId\":94031,\"journal\":{\"name\":\"IEEE transactions on biomedical circuits and systems\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10400847\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IEEE transactions on biomedical circuits and systems\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://ieeexplore.ieee.org/document/10400847/\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE transactions on biomedical circuits and systems","FirstCategoryId":"1085","ListUrlMain":"https://ieeexplore.ieee.org/document/10400847/","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
NeuroBus - Architecture for an Ultra-Flexible Neural Interface
This article presents the system architecture for an implant concept called
NeuroBus
. Tiny distributed direct digitizing neural recorder ASICs on an ultra-flexible polyimide substrate are connected in a bus-like structure, allowing short connections between electrode and recording front-end with low wiring effort and high customizability. The small size (344
$\,\mu$
m × 294
$\mu$
m) of the ASICs and the ultraflexible substrate allow a low bending stiffness, enabling the implant to adapt to the curvature of the brain and achieving high structural biocompatibility. We introduce the architecture, the integrated building blocks, and the post-CMOS processes required to realize a
NeuroBus
, and we characterize the prototyped direct digitizing neural recorder front-end as well as polyimide-based ECoG brain interface. A rodent animal model is further used to validate the joint capability of the recording front-end and thin-film electrode array.