X 射线自由电子激光诱导声学显微镜(XFELAM)

IF 7.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL Photoacoustics Pub Date : 2024-01-13 DOI:10.1016/j.pacs.2024.100587
Seongwook Choi , Sinyoung Park , Jiwoong Kim , Hyunhee Kim , Seonghee Cho , Sunam Kim , Jaeku Park , Chulhong Kim
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引用次数: 0

摘要

X 射线自由电子激光器(XFEL)极大地推动了 X 射线成像技术的发展,并促成了重要的科学成就。XFEL 的超高功率、短脉宽、低发射率和高相干性使得吸收/发射光谱、衍射成像和散射成像等多种成像技术成为可能。在这里,我们展示了一种基于 XFEL 的新型成像模式,它利用了 X 射线诱导声学(XA)效应,我们称之为 X 射线自由电子激光诱导声学显微镜(XFELAM)。首先,我们通过检测各种材料的 XA 信号验证了 XA 效应,然后用模拟结果验证了实验结果。接着,在分辨率实验中,我们成功地对钻有不同大小圆孔的图案化钨靶进行了成像,空间分辨率为 7.8 ± 5.1 µm,这是 XA 成像首次实现的微米级分辨率。我们的研究结果表明,新型 XFELAM 可以拓展 XFEL 在基础科学研究各个领域的应用。
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X-ray free-electron laser induced acoustic microscopy (XFELAM)

The X-ray free-electron laser (XFEL) has remarkably advanced X-ray imaging technology and enabled important scientific achievements. The XFEL’s extremely high power, short pulse width, low emittance, and high coherence make possible such diverse imaging techniques as absorption/emission spectroscopy, diffraction imaging, and scattering imaging. Here, we demonstrate a novel XFEL-based imaging modality that uses the X-ray induced acoustic (XA) effect, which we call X-ray free-electron laser induced acoustic microscopy (XFELAM). Initially, we verified the XA effect by detecting XA signals from various materials, then we validated the experimental results with simulation outcomes. Next, in resolution experiments, we successfully imaged a patterned tungsten target with drilled various-sized circles at a spatial resolution of 7.8 ± 5.1 µm, which is the first micron-scale resolution achieved by XA imaging. Our results suggest that the novel XFELAM can expand the usability of XFEL in various areas of fundamental scientific research.

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来源期刊
Photoacoustics
Photoacoustics Physics and Astronomy-Atomic and Molecular Physics, and Optics
CiteScore
11.40
自引率
16.50%
发文量
96
审稿时长
53 days
期刊介绍: The open access Photoacoustics journal (PACS) aims to publish original research and review contributions in the field of photoacoustics-optoacoustics-thermoacoustics. This field utilizes acoustical and ultrasonic phenomena excited by electromagnetic radiation for the detection, visualization, and characterization of various materials and biological tissues, including living organisms. Recent advancements in laser technologies, ultrasound detection approaches, inverse theory, and fast reconstruction algorithms have greatly supported the rapid progress in this field. The unique contrast provided by molecular absorption in photoacoustic-optoacoustic-thermoacoustic methods has allowed for addressing unmet biological and medical needs such as pre-clinical research, clinical imaging of vasculature, tissue and disease physiology, drug efficacy, surgery guidance, and therapy monitoring. Applications of this field encompass a wide range of medical imaging and sensing applications, including cancer, vascular diseases, brain neurophysiology, ophthalmology, and diabetes. Moreover, photoacoustics-optoacoustics-thermoacoustics is a multidisciplinary field, with contributions from chemistry and nanotechnology, where novel materials such as biodegradable nanoparticles, organic dyes, targeted agents, theranostic probes, and genetically expressed markers are being actively developed. These advanced materials have significantly improved the signal-to-noise ratio and tissue contrast in photoacoustic methods.
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