Bridget F O'Neill, Chad Boeckman, Kristine LeRoy, Chris Linderblood, Taylor Olson, Rachel Woods, Mary Challender
{"title":"IPD079Ea 的环境风险评估：一种从 Ophioglossum pendulum 提取的蛋白质，对玉米中的 Diabrotica spp.","authors":"Bridget F O'Neill, Chad Boeckman, Kristine LeRoy, Chris Linderblood, Taylor Olson, Rachel Woods, Mary Challender","doi":"10.1080/21645698.2023.2299503","DOIUrl":null,"url":null,"abstract":"<p><p>Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (<i>Diabrotica</i> spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from <i>Ophioglossum pendulum</i> and has shown activity against corn rootworm. An environmental risk assessment was conducted for maize event DP-915635-4, which provides control of corn rootworms via expression of the IPD079Ea protein. This assessment focused on IPD079Ea and characterized potential exposure and hazard to non-target organisms (NTOs). For exposure, estimated environmental concentrations (EECs) were calculated. For hazard, laboratory dietary toxicity studies were conducted with IPD079Ea and surrogate non-target organisms. Environmental risk was characterized by comparing hazard and exposure to calculate the margin of exposure (MOE). Based on the MOE values for DP-915635-4 maize, the IPD079Ea protein is not expected to result in unreasonable adverse effects on beneficial NTO populations at environmentally relevant concentrations.</p>","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"15 1","pages":"15-31"},"PeriodicalIF":4.5000,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10802193/pdf/","citationCount":"0","resultStr":"{\"title\":\"An environmental risk assessment of IPD079Ea: a protein derived from <i>Ophioglossum pendulum</i> with activity against <i>Diabrotica</i> spp.In maize.\",\"authors\":\"Bridget F O'Neill, Chad Boeckman, Kristine LeRoy, Chris Linderblood, Taylor Olson, Rachel Woods, Mary Challender\",\"doi\":\"10.1080/21645698.2023.2299503\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (<i>Diabrotica</i> spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from <i>Ophioglossum pendulum</i> and has shown activity against corn rootworm. An environmental risk assessment was conducted for maize event DP-915635-4, which provides control of corn rootworms via expression of the IPD079Ea protein. This assessment focused on IPD079Ea and characterized potential exposure and hazard to non-target organisms (NTOs). For exposure, estimated environmental concentrations (EECs) were calculated. For hazard, laboratory dietary toxicity studies were conducted with IPD079Ea and surrogate non-target organisms. Environmental risk was characterized by comparing hazard and exposure to calculate the margin of exposure (MOE). Based on the MOE values for DP-915635-4 maize, the IPD079Ea protein is not expected to result in unreasonable adverse effects on beneficial NTO populations at environmentally relevant concentrations.</p>\",\"PeriodicalId\":54282,\"journal\":{\"name\":\"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain\",\"volume\":\"15 1\",\"pages\":\"15-31\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2024-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10802193/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1080/21645698.2023.2299503\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/18 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/21645698.2023.2299503","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
An environmental risk assessment of IPD079Ea: a protein derived from Ophioglossum pendulum with activity against Diabrotica spp.In maize.
Farmers in North America face significant pressure from insects in their maize fields, particularly from corn rootworm (Diabrotica spp.). Research into proteins capable of insecticidal activity has found several produced by ferns. One protein, IPD079Ea, was derived from Ophioglossum pendulum and has shown activity against corn rootworm. An environmental risk assessment was conducted for maize event DP-915635-4, which provides control of corn rootworms via expression of the IPD079Ea protein. This assessment focused on IPD079Ea and characterized potential exposure and hazard to non-target organisms (NTOs). For exposure, estimated environmental concentrations (EECs) were calculated. For hazard, laboratory dietary toxicity studies were conducted with IPD079Ea and surrogate non-target organisms. Environmental risk was characterized by comparing hazard and exposure to calculate the margin of exposure (MOE). Based on the MOE values for DP-915635-4 maize, the IPD079Ea protein is not expected to result in unreasonable adverse effects on beneficial NTO populations at environmentally relevant concentrations.
期刊介绍：
GM Crops & Food - Biotechnology in Agriculture and the Food Chain aims to publish high quality research papers, reviews, and commentaries on a wide range of topics involving genetically modified (GM) crops in agriculture and genetically modified food. The journal provides a platform for research papers addressing fundamental questions in the development, testing, and application of transgenic crops. The journal further covers topics relating to socio-economic issues, commercialization, trade and societal issues. GM Crops & Food aims to provide an international forum on all issues related to GM crops, especially toward meaningful communication between scientists and policy-makers.
GM Crops & Food will publish relevant and high-impact original research with a special focus on novelty-driven studies with the potential for application. The journal also publishes authoritative review articles on current research and policy initiatives, and commentary on broad perspectives regarding genetically modified crops. The journal serves a wide readership including scientists, breeders, and policy-makers, as well as a wider community of readers (educators, policy makers, scholars, science writers and students) interested in agriculture, medicine, biotechnology, investment, and technology transfer.
Topics covered include, but are not limited to:
• Production and analysis of transgenic crops
• Gene insertion studies
• Gene silencing
• Factors affecting gene expression
• Post-translational analysis
• Molecular farming
• Field trial analysis
• Commercialization of modified crops
• Safety and regulatory affairs
BIOLOGICAL SCIENCE AND TECHNOLOGY
• Biofuels
• Data from field trials
• Development of transformation technology
• Elimination of pollutants (Bioremediation)
• Gene silencing mechanisms
• Genome Editing
• Herbicide resistance
• Molecular farming
• Pest resistance
• Plant reproduction (e.g., male sterility, hybrid breeding, apomixis)
• Plants with altered composition
• Tolerance to abiotic stress
• Transgenesis in agriculture
• Biofortification and nutrients improvement
• Genomic, proteomic and bioinformatics methods used for developing GM cops
ECONOMIC, POLITICAL AND SOCIAL ISSUES
• Commercialization
• Consumer attitudes
• International bodies
• National and local government policies
• Public perception, intellectual property, education, (bio)ethical issues
• Regulation, environmental impact and containment
• Socio-economic impact
• Food safety and security
• Risk assessments
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