狗和猫的白细胞过敏(体外白细胞聚集)与全身炎症的关联(2017-2022 年)。

IF 1.2 4区 农林科学 Q3 VETERINARY SCIENCES Veterinary clinical pathology Pub Date : 2024-01-18 DOI:10.1111/vcp.13325
Rose D. Nolen-Walston, Darko Stefanoski, Francisco O. Conrado
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引用次数: 0

摘要

背景:白细胞聚集是一种外周血片上的白细胞聚集现象:白细胞增多症是外周血片上白细胞聚集的现象,在人类中,它被用作全身炎症和感染的指标:评估血片检查中的白细胞增多与全身炎症、感染、肿瘤或特定器官系统疾病的生化和临床证据之间的关联:一项采用回顾性分析方法的病例对照研究(2017-2022年)确定了所有在学术转诊中心就诊并在外周血片上发现白细胞增多症的犬科和猫科患者,以及同等数量的物种匹配对照组:结果:共发现 127 例病例(犬类 44 例,猫科 83 例)和 127 例对照。猫科动物样本出现白血病的几率(0.019%)是犬科动物(0.0025%)的 7.6 倍。狗(边际差异为 0.5 毫克/分升,P = .016)和猫(边际差异为 0.67 毫克/分升,P = 结论:白细胞增多症与球蛋白浓度升高之间存在正相关:我们得出结论:球蛋白浓度升高与白细胞增多症之间存在正相关,而白细胞增多症与其他炎症或感染标记物之间的相关性不一致。白细胞增多症总体上比较罕见,但在猫中明显比在狗中更常见。
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Association of leukergy (in vitro leukocyte aggregation) with systemic inflammation in dogs and cats (2017–2022)

Background

Leukergy is the phenomenon of aggregation of leukocytes on a peripheral blood film, and in humans, it is used as an indicator of systemic inflammation and infection.

Objectives

To assess the association of leukergy on blood film examination with biochemical and clinical evidence of systemic inflammation, infection, neoplasia, or specific organ system disease.

Methods

A case–control study using retrospective analysis (2017–2022) identified all canine and feline patients that had been presented to an academic referral center with a finding of leukergy on peripheral blood film and an equal number of species-matched controls.

Results

A total of 127 cases (canine n = 44, feline n = 83) were identified, as well as 127 controls. Feline samples were 7.6× more likely to exhibit leukergy (0.019%) than canine (0.0025%). A positive association was noted between leukergy and higher globulin concentrations in dogs (marginal difference 0.5 mg/dL, P = .016) and cats (marginal difference 0.67 mg/dL, P = <.001). Cats with leukergy had higher WBC counts and were less likely to be diagnosed with cardiac or urinary tract disease than controls. Dogs with leukergy had lower WBC counts and were more likely to be febrile but were less likely to have urinary tract disease than controls. No association was found with neutrophil toxic change or band forms, systemic antimicrobial therapy, or signalment.

Conclusions

We conclude that there is a positive association between increased globulin concentrations and leukergy and inconsistent associations between leukergy and other markers of inflammation or infection. Leukergy is rare overall but markedly more common in cats than dogs.

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来源期刊
Veterinary clinical pathology
Veterinary clinical pathology 农林科学-兽医学
CiteScore
1.70
自引率
16.70%
发文量
133
审稿时长
18-36 weeks
期刊介绍: Veterinary Clinical Pathology is the official journal of the American Society for Veterinary Clinical Pathology (ASVCP) and the European Society of Veterinary Clinical Pathology (ESVCP). The journal''s mission is to provide an international forum for communication and discussion of scientific investigations and new developments that advance the art and science of laboratory diagnosis in animals. Veterinary Clinical Pathology welcomes original experimental research and clinical contributions involving domestic, laboratory, avian, and wildlife species in the areas of hematology, hemostasis, immunopathology, clinical chemistry, cytopathology, surgical pathology, toxicology, endocrinology, laboratory and analytical techniques, instrumentation, quality assurance, and clinical pathology education.
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