Joan M. Sobo , Nicholas S. Alagna , Sean X. Sun , Katherine L. Wilson , Karen L. Reddy
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引用次数: 0
摘要
核薄层(NL)是核内膜(INM)的重要组成部分,由薄层丝和相关蛋白组成。片层蛋白是维持细胞核完整性和机械性能所必需的 V 型中间丝蛋白。在人体细胞中,"B 型 "片层蛋白(片层 B1 和片层 B2)普遍表达,而 "A 型 "片层蛋白(片层 A、片层 C 和次要异构体)则以组织和发育特异性的方式表达。片层蛋白同源聚合形成的丝主要定位于 INM 附近,但 A 型片层蛋白也定位于核质并在核质中发挥作用。连接蛋白在细胞核的组装、结构、定位和力学方面发挥着核心作用,可调节细胞信号,影响发育、分化和其他活动。这篇综述重点介绍了有关层粘连蛋白细丝结构和调控的最新发现,深入探讨了层粘连蛋白细丝作为细胞骨架和核结构、染色质组织和基因组之间的重要纽带所具有的多方面功能,包括其作为 "机械传感器 "的作用。
Lamins: The backbone of the nucleocytoskeleton interface
The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and consists of lamin filaments and associated proteins. Lamins are type V intermediate filament proteins essential for maintaining the integrity and mechanical properties of the nucleus. In human cells, ‘B-type’ lamins (lamin B1 and lamin B2) are ubiquitously expressed, while ‘A-type’ lamins (lamin A, lamin C, and minor isoforms) are expressed in a tissue- and development-specific manner. Lamins homopolymerize to form filaments that localize primarily near the INM, but A-type lamins also localize to and function in the nucleoplasm. Lamins play central roles in the assembly, structure, positioning, and mechanics of the nucleus, modulating cell signaling and influencing development, differentiation, and other activities. This review highlights recent findings on the structure and regulation of lamin filaments, providing insights into their multifaceted functions, including their role as “mechanosensors”, delving into the emerging significance of lamin filaments as vital links between cytoskeletal and nuclear structures, chromatin organization, and the genome.
期刊介绍:
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.