Samy M. El-Megharbel, Safa H. Qahl, Khaled Althobaiti, Eman H. Al-Thubaiti, Reham Z. Hamza
{"title":"姜黄素与 Mg(II)、Ca(II)、Cu(II)、Cr(III) 和 Se(IV) 金属离子复合物的新型抗氧化活性:合成与光谱研究","authors":"Samy M. El-Megharbel, Safa H. Qahl, Khaled Althobaiti, Eman H. Al-Thubaiti, Reham Z. Hamza","doi":"10.4314/bcse.v38i2.6","DOIUrl":null,"url":null,"abstract":"Curcumin (Cur) metal complexes of Mg(II), Ca(II), Cu(II), Cr(III), and Se(IV) were prepared and characterized using elemental analysis, molar conductance, IR, UV-spectra, 1H NMR, SEM, TEM, and X-ray diffraction. The very low values of molar conductance confirm that Cl- ions are absent inside or outside the chelation sphere confirming their non-electrolytic nature, while for Cr(III) Cur is high compared to other curcumin complexes, confirming that Cl- ions are inside the complexation sphere. Based on IR and electronic spectra, the Cur C=O group in enol form chelated to Mg(II), Ca(II), Cu(II), Cr(III), and tetravalent metal (Se). The surface morphology of the curcumin chelates showed an increase in particle size and irregular grains shaped with an elongated morphology. Transmission electron microscopy revealed that the Cur chelates have spherical black spots like shape with a particle size of 72.21-88.75 nm, 34.89-57.33 nm, and 80.71-100 nm for Cu(II), Zn(II), and Se(IV) Cur respectively. X–ray powder diffraction patterns for Cu(II) Cur complexes showed particle size within 70-90 nm; the antioxidant activities of Cur and its metal complexes were assessed. Results showed that the Cur complexes with Cr, Mg, Ca, Cu, or Se showed potent antioxidant activities. Further studies could evaluate the potency of these complexes to elevate the antioxidant defense system and enhance body functions against degenerative diseases, such as aging, Alzheimer's disease, and viral diseases. \nKEY WORDS: Curcumin, Mg/Cur, Cu/Cur, Se/Cur, Electronic spectra, Antioxidant, Oxidative stress \nBull. Chem. Soc. Ethiop. 2024, 38(2), 347-363. \nDOI: https://dx.doi.org/10.4314/bcse.v38i2.6","PeriodicalId":9501,"journal":{"name":"Bulletin of the Chemical Society of Ethiopia","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antioxidant novel activities of curcumin complexes with Mg(II), Ca(II), Cu(II), Cr(III) and Se(IV) metal ions: synthesis and spectral studies\",\"authors\":\"Samy M. El-Megharbel, Safa H. Qahl, Khaled Althobaiti, Eman H. Al-Thubaiti, Reham Z. Hamza\",\"doi\":\"10.4314/bcse.v38i2.6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Curcumin (Cur) metal complexes of Mg(II), Ca(II), Cu(II), Cr(III), and Se(IV) were prepared and characterized using elemental analysis, molar conductance, IR, UV-spectra, 1H NMR, SEM, TEM, and X-ray diffraction. The very low values of molar conductance confirm that Cl- ions are absent inside or outside the chelation sphere confirming their non-electrolytic nature, while for Cr(III) Cur is high compared to other curcumin complexes, confirming that Cl- ions are inside the complexation sphere. Based on IR and electronic spectra, the Cur C=O group in enol form chelated to Mg(II), Ca(II), Cu(II), Cr(III), and tetravalent metal (Se). The surface morphology of the curcumin chelates showed an increase in particle size and irregular grains shaped with an elongated morphology. Transmission electron microscopy revealed that the Cur chelates have spherical black spots like shape with a particle size of 72.21-88.75 nm, 34.89-57.33 nm, and 80.71-100 nm for Cu(II), Zn(II), and Se(IV) Cur respectively. X–ray powder diffraction patterns for Cu(II) Cur complexes showed particle size within 70-90 nm; the antioxidant activities of Cur and its metal complexes were assessed. 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引用次数: 0
摘要
利用元素分析、摩尔电导、红外光谱、紫外光谱、1H NMR、扫描电镜、透射电镜和 X 射线衍射法制备并表征了 Mg(II)、Ca(II)、Cu(II)、Cr(III) 和 Se(IV) 的姜黄素(Cur)金属配合物。摩尔电导值非常低,证明螯合球内或螯合球外不存在 Cl- 离子,这证实了它们的非电解性质;而与其他姜黄素复合物相比,Cr(III) 的摩尔电导值较高,这证实 Cl- 离子在螯合球内。根据红外光谱和电子能谱,Cur C=O 团以烯醇形式与 Mg(II)、Ca(II)、Cu(II)、Cr(III) 和四价金属(Se)螯合。姜黄素螯合物的表面形态显示出粒径增大和不规则颗粒的拉长形态。透射电子显微镜显示,姜黄素螯合物呈球形黑点状,Cu(II)、Zn(II) 和 Se(IV) Cur 的粒径分别为 72.21-88.75 nm、34.89-57.33 nm 和 80.71-100 nm。Cu(II) Cur 复合物的 X 射线粉末衍射图显示其粒径在 70-90 nm 之间;评估了 Cur 及其金属复合物的抗氧化活性。结果表明,Cur 与 Cr、Mg、Ca、Cu 或 Se 的配合物具有很强的抗氧化活性。进一步的研究可以评估这些复合物在提高抗氧化防御系统和增强机体功能以抵抗衰老、老年痴呆症和病毒性疾病等退化性疾病方面的功效。关键词:姜黄素、镁/姜黄素、铜/姜黄素、硒/姜黄素、电子能谱、抗氧化剂、氧化应激 Bull.Chem.Soc.2024, 38(2), 347-363. DOI: https://dx.doi.org/10.4314/bcse.v38i2.6
Antioxidant novel activities of curcumin complexes with Mg(II), Ca(II), Cu(II), Cr(III) and Se(IV) metal ions: synthesis and spectral studies
Curcumin (Cur) metal complexes of Mg(II), Ca(II), Cu(II), Cr(III), and Se(IV) were prepared and characterized using elemental analysis, molar conductance, IR, UV-spectra, 1H NMR, SEM, TEM, and X-ray diffraction. The very low values of molar conductance confirm that Cl- ions are absent inside or outside the chelation sphere confirming their non-electrolytic nature, while for Cr(III) Cur is high compared to other curcumin complexes, confirming that Cl- ions are inside the complexation sphere. Based on IR and electronic spectra, the Cur C=O group in enol form chelated to Mg(II), Ca(II), Cu(II), Cr(III), and tetravalent metal (Se). The surface morphology of the curcumin chelates showed an increase in particle size and irregular grains shaped with an elongated morphology. Transmission electron microscopy revealed that the Cur chelates have spherical black spots like shape with a particle size of 72.21-88.75 nm, 34.89-57.33 nm, and 80.71-100 nm for Cu(II), Zn(II), and Se(IV) Cur respectively. X–ray powder diffraction patterns for Cu(II) Cur complexes showed particle size within 70-90 nm; the antioxidant activities of Cur and its metal complexes were assessed. Results showed that the Cur complexes with Cr, Mg, Ca, Cu, or Se showed potent antioxidant activities. Further studies could evaluate the potency of these complexes to elevate the antioxidant defense system and enhance body functions against degenerative diseases, such as aging, Alzheimer's disease, and viral diseases.
KEY WORDS: Curcumin, Mg/Cur, Cu/Cur, Se/Cur, Electronic spectra, Antioxidant, Oxidative stress
Bull. Chem. Soc. Ethiop. 2024, 38(2), 347-363.
DOI: https://dx.doi.org/10.4314/bcse.v38i2.6
期刊介绍:
The Bulletin of the Chemical Society of Ethiopia (BCSE) is a triannual publication of the Chemical Society of Ethiopia. The BCSE is an open access and peer reviewed journal. The BCSE invites contributions in any field of basic and applied chemistry.