优质目标产品简介在优化纳米乳剂中的潜力

Devesh U. Kapoor, Rajiv R Kukkar, Mansi Gaur, Bhupendra G. Prajapati, R. Malviya
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引用次数: 0

摘要

在优化纳米乳剂(NEM)过程中应用优质目标产品简介(QTPP),在推进有效给药的药物配方设计方面显示出巨大的潜力。通过将 QTPP 与纳米乳液属性相匹配,这种方法为满足特定治疗目标和反应的定制配方提供了途径。纳入 QTPP 有利于在配方设计中做出明智的选择,涵盖稳定性、药物再释放动力学、生物利用度和精确靶向等关键因素。此外,本综述还广泛探讨了 QTPP 指导策略在完善纳米乳剂优化方面的实际应用。它强调了 QTPP 在预测和调节体内反应方面的关键作用,包括药代动力学和药效学等重要方面。通过对案例研究和研究成果进行深入探讨,本文阐明了将 QTPP 标准与 NEM 特性相结合的有效性。这种方法有助于创造定制的配方,以实现不同的治疗目标。这篇综述综合了当代对利用 QTPP 优化纳米乳液的见解,阐明了 QTPP 简化配方设计、通过期望的药物释放提高治疗效果以及促进制药研究变革的能力。
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The Potential of Quality Target Product Profile in the Optimization of Nanoemulsions
The application of Quality Target Product Profile (QTPP) in optimizing nanoemulsion (NEM) shows immense potential in advancing pharmaceutical formulation design for effective drug delivery. By aligning QTPP with nanoemulsion attributes, this approach offers a pathway to tailored formulations that meet specific therapeutic objectives and responses. Incorporating QTPP facilitates informed choices in formulating design, covering pivotal factors like stability, drug re-lease kinetics, bioavailability, and precise targeting. Moreover, this review extensively explores the real-world application of QTPP-guided tactics in refining nanoemulsion optimization. It high-lights their pivotal role in anticipating and regulating in vivo responses, encompassing vital as-pects like pharmacokinetics and pharmacodynamics. By conducting thorough examinations of case studies and research outcomes, this article clarifies the effectiveness of aligning QTPP crite-ria with NEM characteristics. This approach fosters the creation of customized formulations pre-cisely suited to achieve distinct therapeutic objectives. This review amalgamates contemporary insights into harnessing QTPP for nanoemulsion optimization, illuminating its capacity to stream-line formulation design, amplify treatment effectiveness by desiring drug release, and catalyze transformative shifts in pharmaceutical research.
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来源期刊
Current Nanomedicine
Current Nanomedicine Medicine-Medicine (miscellaneous)
CiteScore
2.00
自引率
0.00%
发文量
15
期刊最新文献
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