线粒体与细胞核之间的通讯通过多种途径调节心肌细胞的增殖。

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-01-31 DOI:10.1186/s13619-024-00186-x
Xinhang Li, Yalin Zhu, Pilar Ruiz-Lozano, Ke Wei
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引用次数: 0

摘要

成年哺乳动物心脏的再生能力仍然是生物学研究中的一项艰巨挑战。尽管对进化和发育过程中再生潜能的丧失进行了广泛的研究,但对心肌细胞增殖机制的揭示仍然遥遥无期。最近的两项突破性研究为线粒体与核之间的通讯提供了新的视角,揭示了调节心肌细胞增殖的新因素。研究发现,脂肪酸氧化和蛋白质翻译这两个线粒体过程是限制心肌细胞增殖的关键因素。抑制这两个过程会导致心肌细胞的细胞周期活动增加,分别通过累积的α-酮戊二酸(αKG)降低H3k4me3水平和激活线粒体未折叠蛋白反应(UPRmt)来介导。在本研究集锦中,我们将讨论这些研究对线粒体-核通讯的新见解、对心肌细胞生物学和心血管疾病的广泛影响,以及由这些研究启发的引人入胜的科学问题,这些问题可能会促进未来对心肌细胞代谢、增殖和线粒体-核通讯的详细分子机制的研究。
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Mitochondrial-to-nuclear communications through multiple routes regulate cardiomyocyte proliferation.

The regenerative capacity of the adult mammalian heart remains a formidable challenge in biological research. Despite extensive investigations into the loss of regenerative potential during evolution and development, unlocking the mechanisms governing cardiomyocyte proliferation remains elusive. Two recent groundbreaking studies have provided fresh perspectives on mitochondrial-to-nuclear communication, shedding light on novel factors that regulate cardiomyocyte proliferation. The studies identified two mitochondrial processes, fatty acid oxidation and protein translation, as key players in restricting cardiomyocyte proliferation. Inhibition of these processes led to increased cell cycle activity in cardiomyocytes, mediated by reduction in H3k4me3 levels through accumulated α-ketoglutarate (αKG), and activation of the mitochondrial unfolded protein response (UPRmt), respectively. In this research highlight, we discuss the novel insights into mitochondrial-to-nuclear communication presented in these studies, the broad implications in cardiomyocyte biology and cardiovascular diseases, as well as the intriguing scientific questions inspired by the studies that may facilitate future investigations into the detailed molecular mechanisms of cardiomyocyte metabolism, proliferation, and mitochondrial-to-nuclear communications.

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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
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