Jinli Zhou , Junjie Zheng , Chenxiao Wang , Ge Zhang , Hongying Yang , Fan Xiong , Mengzhao Fan , Zheng Wang , Yunfei Li , Chaoran Yang
{"title":"用于生物标记检测的电纺生物传感器","authors":"Jinli Zhou , Junjie Zheng , Chenxiao Wang , Ge Zhang , Hongying Yang , Fan Xiong , Mengzhao Fan , Zheng Wang , Yunfei Li , Chaoran Yang","doi":"10.1016/j.colcom.2024.100767","DOIUrl":null,"url":null,"abstract":"<div><p>Biosensors based on electrospun nanofibers have found extensive applications in the field of biomarker detection. Nanofibers, owing to their advantages such as porosity, high surface area, and significant loading capacity, play a crucial role in immobilizing recognition elements, directly interacting with target analytes, enhancing antibody fixation positions, and improving the activity and lifespan of biomolecules. This, in turn, enables the high sensitivity and selectivity detection of major disease biomarkers. This review begins by summarizing the structure and processing methods of electrospun nanofiber biosensors, followed by an overview of the physical, chemical detection, and immobilization patterns in biomarker detection. Subsequently, a brief retrospective analysis of the research progress in biomarker detection is presented. Additionally, the application of electrospun nanofiber biosensors in various disease areas, including cancer, cardiovascular, neurological, metabolic, and infectious diseases, is discussed based on biomedical classifications. Finally, the challenges faced by electrospun nanofiber biosensors in biomarker detection are summarized, and the future directions for the development of electrospun nanofiber biosensors are highlighted</p></div>","PeriodicalId":10483,"journal":{"name":"Colloid and Interface Science Communications","volume":"59 ","pages":"Article 100767"},"PeriodicalIF":4.7000,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2215038224000025/pdfft?md5=d013c7ccaaffaeb9eae773a7c00d80d3&pid=1-s2.0-S2215038224000025-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Electrospun biosensors for biomarker detection\",\"authors\":\"Jinli Zhou , Junjie Zheng , Chenxiao Wang , Ge Zhang , Hongying Yang , Fan Xiong , Mengzhao Fan , Zheng Wang , Yunfei Li , Chaoran Yang\",\"doi\":\"10.1016/j.colcom.2024.100767\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Biosensors based on electrospun nanofibers have found extensive applications in the field of biomarker detection. Nanofibers, owing to their advantages such as porosity, high surface area, and significant loading capacity, play a crucial role in immobilizing recognition elements, directly interacting with target analytes, enhancing antibody fixation positions, and improving the activity and lifespan of biomolecules. This, in turn, enables the high sensitivity and selectivity detection of major disease biomarkers. This review begins by summarizing the structure and processing methods of electrospun nanofiber biosensors, followed by an overview of the physical, chemical detection, and immobilization patterns in biomarker detection. Subsequently, a brief retrospective analysis of the research progress in biomarker detection is presented. Additionally, the application of electrospun nanofiber biosensors in various disease areas, including cancer, cardiovascular, neurological, metabolic, and infectious diseases, is discussed based on biomedical classifications. Finally, the challenges faced by electrospun nanofiber biosensors in biomarker detection are summarized, and the future directions for the development of electrospun nanofiber biosensors are highlighted</p></div>\",\"PeriodicalId\":10483,\"journal\":{\"name\":\"Colloid and Interface Science Communications\",\"volume\":\"59 \",\"pages\":\"Article 100767\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2024-01-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2215038224000025/pdfft?md5=d013c7ccaaffaeb9eae773a7c00d80d3&pid=1-s2.0-S2215038224000025-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloid and Interface Science Communications\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2215038224000025\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Interface Science Communications","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2215038224000025","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Biosensors based on electrospun nanofibers have found extensive applications in the field of biomarker detection. Nanofibers, owing to their advantages such as porosity, high surface area, and significant loading capacity, play a crucial role in immobilizing recognition elements, directly interacting with target analytes, enhancing antibody fixation positions, and improving the activity and lifespan of biomolecules. This, in turn, enables the high sensitivity and selectivity detection of major disease biomarkers. This review begins by summarizing the structure and processing methods of electrospun nanofiber biosensors, followed by an overview of the physical, chemical detection, and immobilization patterns in biomarker detection. Subsequently, a brief retrospective analysis of the research progress in biomarker detection is presented. Additionally, the application of electrospun nanofiber biosensors in various disease areas, including cancer, cardiovascular, neurological, metabolic, and infectious diseases, is discussed based on biomedical classifications. Finally, the challenges faced by electrospun nanofiber biosensors in biomarker detection are summarized, and the future directions for the development of electrospun nanofiber biosensors are highlighted
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Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.
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