研究真菌次级代谢物的化学表观遗传修饰方法的进展

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2024-02-02 DOI:10.2174/0118756298278037231122041718
Bing Liu, Yuxin Wang, Ning Chen, Chenxue Li, Jintong Zhao, Ting Li
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引用次数: 0

摘要

:真菌产生的次生代谢物是新药开发的重要资源,而真菌次生代谢物的生物合成与其基因簇所在染色体的表观遗传状态密切相关。然而,诱导真菌沉默基因表达是现阶段面临的挑战之一。化学表观遗传修饰是一种简单有效的真菌代谢调控方法,通过在培养基中添加化学表观遗传修饰剂,激活真菌体内沉默的代谢途径,从而产生隐性天然产物。本文综述了利用化学表观遗传修饰增加真菌次生代谢产物化学多样性的研究进展,旨在为深入研究真菌天然产物提供参考。
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Advances in Chemical Epigenetic Modification Methods in the Study of Fungal Secondary Metabolites
: The secondary metabolites produced by fungi are an important resource for new drug development, and the biosynthesis of fungal secondary metabolites is closely related to the epigenetic status of the chromosomes in which their gene clusters are located. However, the induction of fungal silencing of gene expression is one of the challenges faced at this stage. Chemical epigenetic modification is a simple and effective method to regulate fungal metabolism by adding chemical epigenetic modifiers to the culture medium to activate silent metabolic pathways in the fungus, resulting in the production of cryptic natural products. This paper reviews the progress of research on increasing the chemical diversity of fungal secondary metabolites using chemical epigenetic modifications, with the aim of providing a reference for the in-depth study of fungal natural products.
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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