Amir Hossein Behnoush , Asma Mousavi , Elina Ghondaghsaz , Shayan Shojaei , Alessandro Cannavo , Amirmohammad Khalaji
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引用次数: 0
摘要
胰岛素抵抗(IR)被认为是抑郁症的潜在风险因素,而抑郁症是一种影响全球相当一部分成年人的主要常见疾病。基于这一前提,本研究系统地调查了所有关于抑郁症或有自杀想法/企图的患者的甘油三酯-葡萄糖(TyG)指数(IR 的替代标志物)的研究。本研究全面检索了四个在线数据库(PubMed、Scopus、Embase 和 Web of Science)。经过筛选,共纳入了 7 项研究,共有 58,981 名参与者,其中男性占 46.4%。虽然研究报告之间存在一些差异,但大多数纳入的研究都报告了抑郁症患者较高的 TyG 指数水平。此外,在大多数情况下,TyG 指数每增加 1 个单位,患抑郁症的几率就会显著增加。最后,较高的 TyG 水平与自杀意念和企图自杀有关。因此,本研究强调,亟需进一步开展这方面的研究,并在可能的情况下将 TyG 指数测量与常规抑郁症筛查结合起来,以避免未来发生致命事件。
The importance of assessing the triglyceride-glucose index (TyG) in patients with depression: A systematic review
Insulin resistance (IR) has been proposed as a potential risk factor for depression, a major common disorder affecting a significant proportion of adults worldwide. Based on this premise, this study systematically investigated all the studies examining the triglyceride-glucose (TyG) index, a surrogate marker of IR, in patients with depression or suicidal ideas/attempts. Four online databases (PubMed, Scopus, Embase, and Web of Science) were comprehensively searched. After screening, seven studies were included, comprised of 58,981 participants and 46.4% male. While there were some discrepancies among the reports of studies, most of the included studies reported higher levels of TyG index in patients with depression. Moreover, in most cases, a 1-unit increase in the TyG index was associated with significantly higher odds of depression. At last, higher TyG levels were associated with suicidal ideation and attempts. Therefore, this study emphasizes the critical need to further research in this regard and possibly integrate the TyG index measure with routine depression screening to avoid fatal events in the future.
期刊介绍:
The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.