用于增强连续流生物催化的辅助因子固定化研究进展

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Flow Chemistry Pub Date : 2024-02-14 DOI:10.1007/s41981-024-00315-2
Bente Reus, Matteo Damian, Francesco G. Mutti
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引用次数: 0

摘要

生物催化与连续流化学的融合为可持续高效化学合成开辟了新的机遇。对于各种具有工业吸引力的生物催化反应来说,依赖于辅因子的酶是必不可少的。然而,由于辅因子的固有成本以及需要大量外部供应,在工业中实施这些酶和生物催化反应仍然具有挑战性。开发高效、低成本、简单和多用途的辅助因子固定化方法可以解决流动生物催化的这一重要障碍。本综述通过分析现有方法(包括共价拴系、离子吸附、物理夹持及其混合变体)的优势和目前的局限性,探讨了用于生物催化的辅助因子固定化的最新进展。此外,本综述还分析了所有这些固定化技术在连续流化学中的具体应用,并为这一领域的未来工作提供了展望。本综述将成为指导该领域走向更具可持续性和经济可行性的连续流生物催化的指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Advances in cofactor immobilization for enhanced continuous-flow biocatalysis

The merging of biocatalysis with continuous-flow chemistry opens up new opportunities for sustainable and efficient chemical synthesis. Cofactor-dependent enzymes are essential for various industrially attractive biocatalytic reactions. However, implementing these enzymes and biocatalytic reactions in industry remains challenging due to the inherent cost of cofactors and the requirement for their external supply in significant quantities. The development of efficient, low cost, simple and versatile methods for cofactor immobilization can address this important obstacle for biocatalysis in flow. This review explores recent progress in cofactor immobilization for biocatalysis by analyzing advantages and current limitations of the available methods that comprise covalent tethering, ionic adsorption, physical entrapment, and hybrid variations thereof. Moreover, this review analyzes all these immobilization techniques specifically for their utilization in continuous-flow chemistry and provides a perspective for future work in this area. This review will serve as a guide for steering the field towards more sustainable and economically viable continuous-flow biocatalysis.

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来源期刊
Journal of Flow Chemistry
Journal of Flow Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
6.40
自引率
3.70%
发文量
29
审稿时长
>12 weeks
期刊介绍: The main focus of the journal is flow chemistry in inorganic, organic, analytical and process chemistry in the academic research as well as in applied research and development in the pharmaceutical, agrochemical, fine-chemical, petro- chemical, fragrance industry.
期刊最新文献
Rapid and practical synthesis of N-protected amino ketones in continuous flow via pre-deprotonation protocol Expedited access to β-lactams via a telescoped three-component Staudinger reaction in flow Efficient “One-Column” grignard generation and reaction in continuous flow Two deep learning methods in comparison to characterize droplet sizes in emulsification flow processes Enhanced emulsification process between viscous liquids in an ultrasonic capillary microreactor: mechanism analysis and application in nano-emulsion preparation
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