尼日利亚接受胰岛素治疗的 2 型糖尿病门诊患者中的肥胖症和低血糖症--胰岛素治疗 2 型糖尿病门诊患者多中心评估(METOIN)研究提供的数据

M. Nkpozi, I.O. Mbah, G.E. Bozimo, K. Akhidue, C. Ezeude, S.U. Ogbonna, F.A. Owolabi
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引用次数: 0

摘要

背景和目的:尽管早期使用胰岛素对实现良好的血糖控制有明显的益处,但与胰岛素相关的超重/肥胖和低血糖问题仍令人担忧。尼日利亚接受胰岛素治疗的 2 型糖尿病(T2DM)门诊患者对这些副作用的负担尚不清楚。研究对象和方法:这是一项前瞻性、横断面和观察性研究,在五家三级医疗机构同时招募符合研究纳入标准并同意接受胰岛素治疗的 2 型糖尿病门诊患者,并通过研究人员发放的调查问卷获取相关数据。获得的数据包括性别、关节测量、低血糖和治疗地点等,并使用社会科学统计软件包(SPSS)23.0 版软件进行了分析。结果研究共招募了 245 名 T2DM 门诊患者,其中男性 107 人(43.7%),女性 138 人(56.3%)。其中,121 名(49.8%)患者超重,70 名(28.7%)患者肥胖。其中,104 名(42.4%)接受胰岛素治疗的 2 型糖尿病门诊患者报告有低血糖症状,83 名(79.8%)患者有轻微低血糖症状:大量接受胰岛素治疗的 2 型糖尿病门诊患者超重/肥胖,其中大部分患者有轻度低血糖。
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Obesity and hypoglycaemia in type 2 diabetes mellitus outpatients on insulin therapy in Nigeria–data from the multicentre evaluation of type 2 diabetes mellitus outpatients patients on insulin therapy (METOIN) study
Background and Objective: Despite the obvious benefits of early insulin use in achieving good glycaemic control, insulin linked  overweight/obesity and hypoglycaemia are sources of concern and worry. Burden of these side effects among type 2 diabetes mellitus  (T2DM) outpatients on insulin therapy in Nigeria is unknown. Subjects and Methods: This was a prospective, cross sectional and observational study in which consenting T2DM outpatients that meet  the inclusion criteria for the study in five tertiary health facilities were simultaneously recruited and relevant data obtained via  investigator-administered questionnaire. Data obtained which included gender, arthropometric measures, hypoglycaemia and where it  was treated were analyzed using Statistical Package for Social Sciences (SPSS) version 23.0 software. Results: A total of 245 T2DM outpatients were recruited into the study, made up of 107 (43.7%) male and 138 (56.3%) female. Of this, 121  (49.8%) patients were overweight while 70 (28.7%) were obese. Among the patients, 104 (42.4%) T2DM outpatients on insulin therapy  reported hypoglycaemia which was mild in 83 (79.8%) of the patients Conclusion: A significant number of the type 2 DM outpatients on  insulin therapy were overweight/obese with mild hypoglycaemia in a majority of them. 
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