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A retrospective assessment of rifampicin resistance in paediatric tuberculosis in a tertiary hospital in south west Nigeria 尼日利亚西南部一家三级医院对小儿结核病利福平耐药性的回顾性评估
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.6
I. Otaigbe, C. Elikwu, T. Oluwole, A.E. Ogunlolu, O.E. Oseni, O.D. Bello, P.O. Olayiwola, V.C. Dike-Israel, G.J. Atuk
Objectives: Children infected with tuberculosis, including drug resistant tuberculosis serve as reservoirs for Tuberculosis (TB) and as  indicators of recent or ongoing transmission in the community. The aim of this study was to evaluate the prevalence of rifampicin  resistance in paediatric tuberculosis in Babcock University Teaching Hospital, Ilishan Remo, Ogun State, Nigeria Methodology: This was a retrospective study that involved a review of medical microbiology laboratory records to analyze GeneXpert  results of sputum samples obtained from pediatric patients with tuberculosis between January 2017 and March 2022. Aconvenience  sampling method was used to select cases who met the study's inclusion criteria until the sample size was attained. Results: The medical laboratory records of 1046 subjects were analyzed in this study of which 556 (53.2%) were males. The mean age of  all the patients was 10.77±4.38 years and majority of the respondents 445 (42.5%) were in the age group 11-15 years. Fifty patients (4.8%)  had positive GeneXpert results of which 3 (6.0%) were Rifampicin resistant. Conclusion: In order to lower the burden of TB globally more efforts should be made to reduce paediatric TB.    French title: Une évaluation rétrospective de la résistance à la rifampicine dans la tuberculose pédiatrique dans un hôpital tertiaire du sud-ouest du NigériaObjectif de l'étude: Les enfants infectés par la tuberculose, y compris la tuberculose pharmaco résistante, servent de réservoirs de  tuberculose (TB) et d'indicateurs de transmission récente ou en cours dans la communauté. Le but de cette étude était d'évaluer la  prévalence de la résistance à la rifampicine dans la tuberculose pédiatrique à l'hôpital universitaire Babcock, Ilishan Remo, État d'Ogun,  Nigéria. Méthode de l'étude : Il s'agissait d'une étude rétrospective qui impliquait un examen des dossiers de laboratoire de microbiologie  médicale pour analyser les résultats GeneXpert d'échantillons d'expectorations obtenus auprès de patients pédiatriques atteints de  tuberculose entre janvier 2017 et mars 2022. Une méthode d'échantillonnage de commodité a été utilisée pour sélectionner les cas  répondant aux critères d'inclusion de l'étude. Critères jusqu'à ce que la taille de l'échantillon soit atteinte. Résultat de l'étude : Les dossiers de laboratoire médical de 1 046 sujets ont été analysés dans cette étude, dont 556 (53,2 %) étaient des  hommes. L'âge moyen de tous les patients était de 10,77 ± 4,38 ans et la majorité des répondants, 445 (42,5 %), appartenaient à la  tranche d'âge de 11 à 15 ans. Cinquante patients (4,8 %) ont eu des résultats GeneXpert positifs, dont 3 (6,0 %) étaient résistants à la  rifampicine. Conclusion : Afin de réduire le fardeau de la tuberculose à l'échelle mondiale, des efforts supplémentaires doivent être déployés pour  réduire la tuberculose pédiatrique.
目的:感染结核病(包括耐药性结核病)的儿童是结核病(TB)的储藏库,也是近期或正在社区传播的指标。本研究旨在评估尼日利亚奥贡州伊利山雷莫巴布科克大学教学医院儿科结核病患者对利福平耐药性的流行情况。 方法:这是一项回顾性研究,研究人员查阅了医学微生物学实验室的记录,分析了 2017 年 1 月至 2022 年 3 月期间从儿科结核病患者处获得的痰样本的 GeneXpert 结果。研究采用便利抽样法选择符合研究纳入标准的病例,直至达到样本量。结果:本研究分析了 1046 名受试者的医学实验室记录,其中 556 人(53.2%)为男性。所有患者的平均年龄为(10.77±4.38)岁,445 名受访者(42.5%)的年龄在 11-15 岁之间。50名患者(4.8%)的基因Xpert结果呈阳性,其中3名患者(6.0%)对利福平耐药。结论:为降低全球结核病负担,应加大力度减少儿童结核病。 研究目的:受结核病感染的儿童,包括耐药性结核病患者,是结核病(TB)的贮存库,也是近期或正在社区传播的指标。本研究旨在评估尼日利亚奥贡州伊利山雷莫市巴布科克教学医院儿科结核病患者对利福平耐药性的流行情况。研究方法:这是一项回顾性研究,研究人员查阅了医学微生物实验室记录,分析了2017年1月至2022年3月期间从儿科肺结核患者处获得的痰样本的GeneXpert结果。研究采用便利抽样法选择符合研究纳入标准的病例。标准,直至达到样本量。研究结果:本研究分析了 1,046 名受试者的医学实验室记录,其中 556 人(53.2%)为男性。所有患者的平均年龄为(10.77 ± 4.38)岁,大多数受访者(445 人,占 42.5%)处于 11-15 岁年龄段。50名患者(4.8%)基因Xpert呈阳性,其中3人(6.0%)对利福平耐药。结论:为了减轻结核病的全球负担,必须做出更多努力来减少儿童结核病。
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引用次数: 0
Exploring atypical manifestations of Mpox: Anarrative review 探索麻风腮的非典型表现:综述
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.9
A.E. Sokunbi, O. Adeyemi
Mpox (formerly referred to as monkey pox), a viral infection known for its characteristic manifestations, presents with atypical symptoms,  leading to diagnostic and management challenges. Recent outbreaks of the disease have also revealed changes in the  epidemiologic patterns of the disease with many cases going unnoticed. These scenarios if not properly identified and addressed can led  to increased healthcare burden created by the virus. To conduct the narrative review of the concerned literature, a comprehensive and  well through search from PUBMED, Google scholar, EMBASE and African Journal Online Evaluating Studies was conducted from published  works between 2003 to 2023. This narrative review aims at exploring the atypical manifestations of Mpox, by reviewing various  manifestations of the disease, examining the overlying mechanisms and factors influencing these manifestations; and more so, assessing various clinical implications and challenges facing its management, with the hope of suggesting future directions in tackling  the clinical implications and challenges. Regarding the atypical manifestations of Mpox, the review focused on the neurological,  dermatological, and respiratory presentations, highlighting the diverse symptoms observed in each case. In addition, accurate diagnosis  of atypical cases is crucial and requires a high index of suspicion, comprehensive differential diagnosis, and appropriate diagnostic  testing. Tailored strategies for treatment are essential to address the specific manifestations observed. For future research, a focus on  elucidating the pathogenesis, identifying risk factors, improving diagnostic approaches, and evaluating treatment strategies for atypical    French title: Mpox cases is required.  Explorer les manifestations atypiques de Mpox: une revue narrative Titre fonctionnement proposé :  Manifestations atypiques de Mpox   La variole du singe (anciennement appelée variole du singe), une infection virale connue pour ses manifestations caractéristiques,  présente des symptômes atypiques, entraînant des défis de diagnostic et de prise en charge. Les récentes épidémies de la maladie ont  également révélé des changements dans les schémas épidémiologiques de la maladie, de nombreux cas passant inaperçus. S'ils ne sont  pas correctement identifiés et traités, ces scénarios peuvent entraîner une augmentation du fardeau des soins de santé créé par le virus.  Pour mener l'examen narratif de la littérature concernée, une recherche complète et approfondie de PUBMED, Google Scholar, EMBASE  et African Journal Online Evaluating Studies a été menée à partir d'ouvrages publiés entre 2003 et 2023. Cette revue narrative vise à  explorer les manifestations atypiques de la Mpox, en passant en revue diverses manifestations de la maladie, en examinant les  mécanismes sous-jacents et les facteurs influençant ces manifestations ; et plus encore, évaluer diverses implications cliniques et défis  auxquels est confrontée
痘疹(原称猴痘)是一种以特征性表现而闻名的病毒感染,其症状不典型,给诊断和管理带来了挑战。最近该疾病的爆发也揭示了该疾病流行模式的变化,许多病例被忽视。如果不能正确识别和处理这些情况,病毒可能会增加医疗负担。为了对相关文献进行叙事性综述,我们对 2003 年至 2023 年间发表的文献进行了全面、彻底的搜索,包括 PUBMED、Google scholar、EMBASE 和 African Journal Online Evaluating Studies。这篇叙事性综述旨在通过回顾麻风腮的各种表现,研究影响这些表现的内在机制和因素,从而探讨麻风腮的非典型表现;此外,还评估了麻风腮的各种临床影响及其管理所面临的挑战,希望为应对这些临床影响和挑战提出未来的方向。关于麻风腮的非典型表现,综述侧重于神经系统、皮肤病和呼吸系统的表现,强调了在每个病例中观察到的不同症状。此外,非典型病例的准确诊断至关重要,需要高度怀疑、全面鉴别诊断和适当的诊断测试。针对所观察到的特殊表现,量身定制的治疗策略至关重要。在未来的研究中,需要重点阐明发病机制、确定风险因素、改进诊断方法以及评估非典型法文标题:Mpox病例的治疗策略。 探索麻风腮的非典型表现:叙述性综述 拟议工作标题 : 猴痘的非典型表现 猴痘(旧称猴痘)是一种以特征性表现而闻名的病毒感染,它的非典型症状给诊断和治疗带来了挑战。最近的流行病也揭示了该疾病流行模式的变化,许多病例未被发现。如果不能正确识别和治疗,这些情况可能会导致病毒造成的医疗负担加重。 为了对相关文献进行叙述性综述,我们在 PUBMED、谷歌学术、EMBASE 和非洲在线评估研究期刊上对 2003 年至 2023 年间发表的文献进行了全面深入的搜索。这篇叙事性综述旨在探讨麻风腮的非典型表现,回顾该疾病的各种表现,研究影响这些表现的潜在机制和因素;更重要的是,评估麻风腮的各种临床意义和管理中面临的挑战,希望能为解决临床意义和挑战提出未来的方向。 关于麻风腮的非典型表现,综述重点关注神经系统、皮肤和呼吸系统表现,强调了在每个病例中观察到的各种症状。此外,非典型病例的准确诊断至关重要,需要高度怀疑、全面鉴别诊断和适当的诊断测试。针对观察到的特殊表现,量身定制的治疗策略至关重要。在未来的研究中,有必要重点阐明 Mpox 非典型病例的发病机制、确定风险因素、改进诊断方法和评估治疗策略。
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引用次数: 0
Obesity and hypoglycaemia in type 2 diabetes mellitus outpatients on insulin therapy in Nigeria–data from the multicentre evaluation of type 2 diabetes mellitus outpatients patients on insulin therapy (METOIN) study 尼日利亚接受胰岛素治疗的 2 型糖尿病门诊患者中的肥胖症和低血糖症--胰岛素治疗 2 型糖尿病门诊患者多中心评估(METOIN)研究提供的数据
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.1
M. Nkpozi, I.O. Mbah, G.E. Bozimo, K. Akhidue, C. Ezeude, S.U. Ogbonna, F.A. Owolabi
Background and Objective: Despite the obvious benefits of early insulin use in achieving good glycaemic control, insulin linked  overweight/obesity and hypoglycaemia are sources of concern and worry. Burden of these side effects among type 2 diabetes mellitus  (T2DM) outpatients on insulin therapy in Nigeria is unknown. Subjects and Methods: This was a prospective, cross sectional and observational study in which consenting T2DM outpatients that meet  the inclusion criteria for the study in five tertiary health facilities were simultaneously recruited and relevant data obtained via  investigator-administered questionnaire. Data obtained which included gender, arthropometric measures, hypoglycaemia and where it  was treated were analyzed using Statistical Package for Social Sciences (SPSS) version 23.0 software. Results: A total of 245 T2DM outpatients were recruited into the study, made up of 107 (43.7%) male and 138 (56.3%) female. Of this, 121  (49.8%) patients were overweight while 70 (28.7%) were obese. Among the patients, 104 (42.4%) T2DM outpatients on insulin therapy  reported hypoglycaemia which was mild in 83 (79.8%) of the patients Conclusion: A significant number of the type 2 DM outpatients on  insulin therapy were overweight/obese with mild hypoglycaemia in a majority of them. 
背景和目的:尽管早期使用胰岛素对实现良好的血糖控制有明显的益处,但与胰岛素相关的超重/肥胖和低血糖问题仍令人担忧。尼日利亚接受胰岛素治疗的 2 型糖尿病(T2DM)门诊患者对这些副作用的负担尚不清楚。研究对象和方法:这是一项前瞻性、横断面和观察性研究,在五家三级医疗机构同时招募符合研究纳入标准并同意接受胰岛素治疗的 2 型糖尿病门诊患者,并通过研究人员发放的调查问卷获取相关数据。获得的数据包括性别、关节测量、低血糖和治疗地点等,并使用社会科学统计软件包(SPSS)23.0 版软件进行了分析。结果研究共招募了 245 名 T2DM 门诊患者,其中男性 107 人(43.7%),女性 138 人(56.3%)。其中,121 名(49.8%)患者超重,70 名(28.7%)患者肥胖。其中,104 名(42.4%)接受胰岛素治疗的 2 型糖尿病门诊患者报告有低血糖症状,83 名(79.8%)患者有轻微低血糖症状:大量接受胰岛素治疗的 2 型糖尿病门诊患者超重/肥胖,其中大部分患者有轻度低血糖。
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引用次数: 0
Treatment of chronic hepatitis B infection in Nigeria: The need for a paradigm shift 尼日利亚慢性乙型肝炎感染的治疗:转变模式的必要性
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.8
A.R. Yusuf, A.D. Dauda
No Abstract.
无摘要。
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引用次数: 0
Correlation between Hearing Thresholds and Habitual use of Headphones/Earphones among Students of Tertiary Institutions in Northwestern Nigeria 尼日利亚西北部高等院校学生听力阈值与习惯使用耳机/耳麦之间的相关性
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.4
K. Haruna, A.D. Salisu, S. Labaran, M.B. Fufore
Background: There has been ongoing concern that prolonged use of headphones/earphones that amplify the sound intensity can lead  to noise induced hearing loss. This study therefore aimed at determining the correlation between hearing thresholds and habitual usage  of headphones/earphones among undergraduates of tertiary institutions in Northwestern Nigeria. Method: A cross-sectional study was  conducted on young adults, who are undergraduate students of tertiary institutions, to assess the hearing thresholds of individuals who  frequently use headphones or earphones. Ethical clearance was obtained, and participants who met specific criteria were selected.  Amultistage sampling technique was used, and 272 participants (representing 544 ears) with equal number of controls were recruited.  They completed questionnaires and underwent otoscopic examination and pure tone audiometry (PTA). Those having wax or foreign  bodies in the ears had it removed before performing PTA. The data was recorded and analyzed using SPSS version 20. Frequency tables and variable relationships were examined to determine significance, which was set at a p-value of <0.05. Result: The study involved 272  users of headphones/earphones (representing 544 ears) and an equal number of age- and sex-matched controls. The participants' ages  ranged between 18 and 33, with 50.4% being male. The pure tone average among the headphones/earphones users and the controls  ranged from 11.0 – 43.8dB, with a mean of 20.2±6.0 and 10.6 – 43.2dB, with a mean of 19.6 ± 4.5, respectively. More than half, 280/544  ears (51.5%) of the participants used headphones/earphones for over 4 years, and of these, 222/280 ears (79.3%) used them for 1 – 4  hours daily. Moderate volume was the preferred listening mode for 63.2% of the users. A moderate positive correlation was observed between hearing thresholds and hours of headphone/earphone use, and a weak positive correlation between hearing thresholds and  preferred level of loudness (r = 0.290, p < 0.0001) while no correlation was found between hearing threshold and long-term use (r = 0.003,  p = 0.937). Conclusion: This study suggests that individuals who use headphones or earphones for prolonged periods of listening hours  daily or at higher listening levels tend to have poorer hearing thresholds. 
背景:人们一直担心,长时间使用放大声音强度的耳机会导致噪音引起的听力损失。因此,本研究旨在确定尼日利亚西北部高等院校本科生的听阈与习惯使用耳机之间的相关性。研究方法对高等院校本科生中的年轻人进行横断面研究,以评估经常使用耳机的人的听阈。研究获得了伦理许可,并挑选了符合特定标准的参与者。 研究采用多级抽样技术,共招募了 272 名参与者(代表 544 只耳朵)和同等数量的对照组。 他们填写了调查问卷,并接受了耳镜检查和纯音测听(PTA)。耳内有耳垢或异物的受试者在进行纯音测听前已将耳垢或异物取出。数据使用 SPSS 20 版本进行记录和分析。对频率表和变量关系进行了检验,以确定其显著性,P 值设定为小于 0.05。研究结果研究涉及 272 名耳机/耳麦用户(代表 544 只耳朵)和同等数量的年龄和性别匹配的对照组。参与者的年龄在 18 至 33 岁之间,50.4% 为男性。耳机/耳麦使用者和对照组的纯音平均值分别为 11.0 - 43.8dB(平均值为 20.2±6.0)和 10.6 - 43.2dB(平均值为 19.6±4.5)。超过半数的参与者(280 人/544 耳(51.5%))使用耳机/耳麦的时间超过 4 年,其中 222 人/280 耳(79.3%)每天使用耳机/耳麦的时间为 1 - 4 小时。63.2%的使用者首选中等音量的聆听模式。听力阈值与使用耳机的时长呈中度正相关,听力阈值与偏好的响度呈弱正相关(r = 0.290,p < 0.0001),而听力阈值与长期使用之间没有相关性(r = 0.003,p = 0.937)。结论这项研究表明,每天长时间使用耳机或听力水平较高的人往往听阈较低。
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引用次数: 0
Antibiotic prophylaxis in obstetric and gynaecological procedures: Acomparative study between two regimens of antibiotics 妇产科手术中的抗生素预防:两种抗生素方案的比较研究
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.5
A.K Akiseku, O.E. Jagun, H.O.A Kuku, A.B. Akinpelu, A. O. Olatunji, A.O. Sule-Odu
Background: Postoperative wound infections have an enormous impact on the quality of life and contribute substantially to the financial  cost of patient care. The study aims to compare the clinical efficacy of two perioperative/postoperative antibiotic regimens, the wound  outcome and difference in cost on healthcare between these regimens. Methods: This is an observational prospective cohort study of 290 women. Women scheduled for elective surgeries in the department  were grouped to have either a combination of ampicillin/cloxacillin (Ampiclox), Gentamicin, and Metronidazole (triple regimen) or a  combination of ceftriaxone and metronidazole (double regimen). Data was analysed using Statistical Package for Social Science (SPSS) Windows version 21. The wound outcome and the cost implication of the antibiotic regimen were compared by chi-square test and t-test  as appropriate. A p-value less than 0.05 was considered significant. Results: The postoperative wound infection rate in this study was 7.24%. There was no statistical significant difference in postoperative  infection in the triple regimen group compared to the double regimen group. However, there was a significantly longer duration of stay  in the hospital in the triple regimen group (P <0.05). There was also a statistical significant difference in the cost of hospital stay and the  cost of antibiotics in the triple regimen group (P<0.05). There was no statistically significant difference in the pattern of organisms  cultured in both groups. Conclusions: Ceftriaxone/Metronidazole regime of antibiotics showed superiority over ampicillin/cloxacillin,  Metronidazole, and Gentamicin in the prevention of postoperative wound infection, hospital stay, and reduced cost of healthcare.    French  title: Prophylaxie antibiotique dans les procédures obstétricales et gynécologiques : une étude comparative entre deux schémas  thérapeutiques antibiotiques Contexte de l'étude: Les infections postopératoires des plaies ont un impact énorme sur la qualité de vie et contribuent considérablement au coût financier des soins aux patients. L'étude vise à comparer l'efficacité clinique de deux régimes antibiotiques  péri opératoires/postopératoires, l'issue de la plaie et la différence de coût des soins de santé entre ces régimes. Paramètres et conception : Il s'agit d'une étude de cohorte prospective observationnelle portant sur 290 femmes. Les femmes devant  subir des interventions chirurgicales électives dans le département ont été regroupées pour recevoir soit une combinaison d'ampicilline/ cloxacilline (Ampiclox), de gentamicine et de métronidazole (triple régime), soit une combinaison de ceftriaxone et de métronidazole  (double régime). Analyse statistique : les données ont été analysées à l'aide du progiciel statistique pour les sciences sociales (PSSS) Windows version 21. L'issue de la plaie et les implications financières du régime antibiotique ont été comparées par le test du chi carré et le te
背景:术后伤口感染对患者的生活质量有很大影响,并大大增加了患者护理的经济成本。本研究旨在比较两种围手术期/术后抗生素治疗方案的临床疗效、伤口疗效以及这两种治疗方案在医疗成本上的差异。方法:这是一项对 290 名妇女进行的前瞻性队列观察研究。计划在该科室进行择期手术的妇女被分组为氨苄西林/氯唑西林(氨苄西林)、庆大霉素和甲硝唑(三联疗法)或头孢曲松和甲硝唑(双联疗法)。数据使用社会科学统计软件包(SPSS)Windows 21 版本进行分析。通过卡方检验(chi-square test)和 t 检验(t-test)对伤口疗效和抗生素方案的成本影响进行比较。P 值小于 0.05 为显著。结果:本研究的术后伤口感染率为 7.24%。与双方案组相比,三方案组的术后感染率无明显统计学差异。然而,三联疗法组的住院时间明显更长(P <0.05)。三联疗法组的住院费用和抗生素费用也有明显差异(P<0.05)。两组培养出的病原菌模式差异无统计学意义。结论:在预防术后伤口感染、缩短住院时间和降低医疗成本方面,头孢曲松/甲硝唑抗生素方案优于氨苄西林/氯唑西林、甲硝唑和庆大霉素。 法文标题: Prophylaxie antibiotique dans les procédures obstétricales et gynécologiques : une étude comparative entre deux schémas thérapeutiques antibiotiques Contexte de l'étude: Les infections postopératoires des plaies ont un impact énorme sur la qualité de vie et contribuent considérablement au coût financier des soins aux patients.本研究旨在比较两种围手术期/术后抗生素治疗方案的临床效果、伤口预后以及不同治疗方案的医疗成本差异。研究背景和设计:这是一项前瞻性观察性队列研究,共有 290 名妇女参加。计划在该科室接受择期手术的妇女被分组,分别接受氨苄西林/环丙西林(Ampiclox)、庆大霉素和甲硝唑(三联疗法)或头孢曲松和甲硝唑(双联疗法)的组合疗法。统计分析:使用社会科学统计软件包(SPSS)Windows 21 版本对数据进行分析。伤口疗效和抗生素方案的财务影响通过卡方检验(chi-square test)和t检验(t-test)进行比较。P 值小于 0.05 即为显著。研究结果:本研究的术后伤口感染率为 7.24%。三联疗法组与双联疗法组的术后感染率在统计学上没有明显差异。 不过,三联疗法组的住院时间明显更长(P<0.05)。三联疗法组的住院费用和抗生素费用也有显著差异(P<0.05)。两组培养出的微生物模式差异无统计学意义。 结论:头孢曲松/甲硝唑抗生素方案在预防术后伤口感染、缩短住院时间和降低医疗费用方面优于氨苄西林/氯唑西林、甲硝唑和庆大霉素。
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引用次数: 0
Exploring atypical manifestations of Mpox: Anarrative review 探索麻风腮的非典型表现:综述
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.9
A.E. Sokunbi, O. Adeyemi
Mpox (formerly referred to as monkey pox), a viral infection known for its characteristic manifestations, presents with atypical symptoms,  leading to diagnostic and management challenges. Recent outbreaks of the disease have also revealed changes in the  epidemiologic patterns of the disease with many cases going unnoticed. These scenarios if not properly identified and addressed can led  to increased healthcare burden created by the virus. To conduct the narrative review of the concerned literature, a comprehensive and  well through search from PUBMED, Google scholar, EMBASE and African Journal Online Evaluating Studies was conducted from published  works between 2003 to 2023. This narrative review aims at exploring the atypical manifestations of Mpox, by reviewing various  manifestations of the disease, examining the overlying mechanisms and factors influencing these manifestations; and more so, assessing various clinical implications and challenges facing its management, with the hope of suggesting future directions in tackling  the clinical implications and challenges. Regarding the atypical manifestations of Mpox, the review focused on the neurological,  dermatological, and respiratory presentations, highlighting the diverse symptoms observed in each case. In addition, accurate diagnosis  of atypical cases is crucial and requires a high index of suspicion, comprehensive differential diagnosis, and appropriate diagnostic  testing. Tailored strategies for treatment are essential to address the specific manifestations observed. For future research, a focus on  elucidating the pathogenesis, identifying risk factors, improving diagnostic approaches, and evaluating treatment strategies for atypical    French title: Mpox cases is required.  Explorer les manifestations atypiques de Mpox: une revue narrative Titre fonctionnement proposé :  Manifestations atypiques de Mpox   La variole du singe (anciennement appelée variole du singe), une infection virale connue pour ses manifestations caractéristiques,  présente des symptômes atypiques, entraînant des défis de diagnostic et de prise en charge. Les récentes épidémies de la maladie ont  également révélé des changements dans les schémas épidémiologiques de la maladie, de nombreux cas passant inaperçus. S'ils ne sont  pas correctement identifiés et traités, ces scénarios peuvent entraîner une augmentation du fardeau des soins de santé créé par le virus.  Pour mener l'examen narratif de la littérature concernée, une recherche complète et approfondie de PUBMED, Google Scholar, EMBASE  et African Journal Online Evaluating Studies a été menée à partir d'ouvrages publiés entre 2003 et 2023. Cette revue narrative vise à  explorer les manifestations atypiques de la Mpox, en passant en revue diverses manifestations de la maladie, en examinant les  mécanismes sous-jacents et les facteurs influençant ces manifestations ; et plus encore, évaluer diverses implications cliniques et défis  auxquels est confrontée
痘疹(原称猴痘)是一种以特征性表现而闻名的病毒感染,其症状不典型,给诊断和管理带来了挑战。最近该疾病的爆发也揭示了该疾病流行模式的变化,许多病例被忽视。如果不能正确识别和处理这些情况,病毒可能会增加医疗负担。为了对相关文献进行叙事性综述,我们对 2003 年至 2023 年间发表的文献进行了全面、彻底的搜索,包括 PUBMED、Google scholar、EMBASE 和 African Journal Online Evaluating Studies。这篇叙事性综述旨在通过回顾麻风腮的各种表现,研究影响这些表现的内在机制和因素,从而探讨麻风腮的非典型表现;此外,还评估了麻风腮的各种临床影响及其管理所面临的挑战,希望为应对这些临床影响和挑战提出未来的方向。关于麻风腮的非典型表现,综述侧重于神经系统、皮肤病和呼吸系统的表现,强调了在每个病例中观察到的不同症状。此外,非典型病例的准确诊断至关重要,需要高度怀疑、全面鉴别诊断和适当的诊断测试。针对所观察到的特殊表现,量身定制的治疗策略至关重要。在未来的研究中,需要重点阐明发病机制、确定风险因素、改进诊断方法以及评估非典型法文标题:Mpox病例的治疗策略。 探索麻风腮的非典型表现:叙述性综述 拟议工作标题 : 猴痘的非典型表现 猴痘(旧称猴痘)是一种以特征性表现而闻名的病毒感染,它的非典型症状给诊断和治疗带来了挑战。最近的流行病也揭示了该疾病流行模式的变化,许多病例未被发现。如果不能正确识别和治疗,这些情况可能会导致病毒造成的医疗负担加重。 为了对相关文献进行叙述性综述,我们在 PUBMED、谷歌学术、EMBASE 和非洲在线评估研究期刊上对 2003 年至 2023 年间发表的文献进行了全面深入的搜索。这篇叙事性综述旨在探讨麻风腮的非典型表现,回顾该疾病的各种表现,研究影响这些表现的潜在机制和因素;更重要的是,评估麻风腮的各种临床意义和管理中面临的挑战,希望能为解决临床意义和挑战提出未来的方向。 关于麻风腮的非典型表现,综述重点关注神经系统、皮肤和呼吸系统表现,强调了在每个病例中观察到的各种症状。此外,非典型病例的准确诊断至关重要,需要高度怀疑、全面鉴别诊断和适当的诊断测试。针对观察到的特殊表现,量身定制的治疗策略至关重要。在未来的研究中,有必要重点阐明 Mpox 非典型病例的发病机制、确定风险因素、改进诊断方法和评估治疗策略。
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引用次数: 0
Obesity and hypoglycaemia in type 2 diabetes mellitus outpatients on insulin therapy in Nigeria–data from the multicentre evaluation of type 2 diabetes mellitus outpatients patients on insulin therapy (METOIN) study 尼日利亚接受胰岛素治疗的 2 型糖尿病门诊患者中的肥胖症和低血糖症--胰岛素治疗 2 型糖尿病门诊患者多中心评估(METOIN)研究提供的数据
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.1
M. Nkpozi, I.O. Mbah, G.E. Bozimo, K. Akhidue, C. Ezeude, S.U. Ogbonna, F.A. Owolabi
Background and Objective: Despite the obvious benefits of early insulin use in achieving good glycaemic control, insulin linked  overweight/obesity and hypoglycaemia are sources of concern and worry. Burden of these side effects among type 2 diabetes mellitus  (T2DM) outpatients on insulin therapy in Nigeria is unknown. Subjects and Methods: This was a prospective, cross sectional and observational study in which consenting T2DM outpatients that meet  the inclusion criteria for the study in five tertiary health facilities were simultaneously recruited and relevant data obtained via  investigator-administered questionnaire. Data obtained which included gender, arthropometric measures, hypoglycaemia and where it  was treated were analyzed using Statistical Package for Social Sciences (SPSS) version 23.0 software. Results: A total of 245 T2DM outpatients were recruited into the study, made up of 107 (43.7%) male and 138 (56.3%) female. Of this, 121  (49.8%) patients were overweight while 70 (28.7%) were obese. Among the patients, 104 (42.4%) T2DM outpatients on insulin therapy  reported hypoglycaemia which was mild in 83 (79.8%) of the patients Conclusion: A significant number of the type 2 DM outpatients on  insulin therapy were overweight/obese with mild hypoglycaemia in a majority of them. 
背景和目的:尽管早期使用胰岛素对实现良好的血糖控制有明显的益处,但与胰岛素相关的超重/肥胖和低血糖问题仍令人担忧。尼日利亚接受胰岛素治疗的 2 型糖尿病(T2DM)门诊患者对这些副作用的负担尚不清楚。研究对象和方法:这是一项前瞻性、横断面和观察性研究,在五家三级医疗机构同时招募符合研究纳入标准并同意接受胰岛素治疗的 2 型糖尿病门诊患者,并通过研究人员发放的调查问卷获取相关数据。获得的数据包括性别、关节测量、低血糖和治疗地点等,并使用社会科学统计软件包(SPSS)23.0 版软件进行了分析。结果研究共招募了 245 名 T2DM 门诊患者,其中男性 107 人(43.7%),女性 138 人(56.3%)。其中,121 名(49.8%)患者超重,70 名(28.7%)患者肥胖。其中,104 名(42.4%)接受胰岛素治疗的 2 型糖尿病门诊患者报告有低血糖症状,83 名(79.8%)患者有轻微低血糖症状:大量接受胰岛素治疗的 2 型糖尿病门诊患者超重/肥胖,其中大部分患者有轻度低血糖。
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引用次数: 0
Significance of anthropometric parameters in the prevalence of type 2 diabetes- a case study of selected hospitals in western Uganda 人体测量参数对 2 型糖尿病患病率的影响--乌干达西部部分医院的案例研究
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.7
O.O. Omoola, A.A. Tijani, A.A. Okesina, E.G. Anyanwu, U.M. Ibe
Background: Diabetes is a group of metabolic disorders characterized and identified by the presence of hyperglycaemia in the absence  of treatment. Despite the increasing awareness of T2DM in the world and strict association of its increasing prevalence with overweight  and obesity relating to skinfold and body circumferences, incidence of T2DM and its various devastating complications continues to be on  the increase because of lack of self-explored techniques for its early prediction. The purpose of this study was to determine variation  in the anthropometric parameters using the mean value of the body circumferences, skinfolds, epicondylar breadth of the femur and  epicondylar breadth of the humerus amongst T2DM patients at two selected tertiary hospitals and non-diabetic persons in Western  Uganda. Methods: The study was composed of 202 adults. 101 Type 2 diabetic adult (T2DM) and 101 non-diabetic adults. Body (chest,  neck, waist, hip, upper arm, thigh and calf) circumferences, skinfolds (abdominal, supraspinale, midaxillary, pectoralis, subscapularis,  mid-thigh, medial calf and triceps) and bony epicondylar breadth was measured following the standard procedure for The International  Society for the Advancement of Kinanthropometry (ISAK). Results: Significantly higher (<0.001) mean (triceps (21.581-12.331mm), subscapularis (21.547-12.093), supraspinale (20.573-8.240mm), pectoralis (14.792-6.726mm), mid-axillary (17.118-8.026mm), abdominal  (24.648- 13.643mm), calf (23.217-13.171), mid-thigh (28.288-16.414) skinfold and upper arm (33.231-27.482cm), neck (36.045-33.045cm),  calf (40.100-34.417cm), chest (99.009-85.199cm), hip (113.176-94.265cm), waist (94.738-74.607cm), thigh (60.939-50.543cm) circumference  as well as humeral (65.203-62.059) and femoral (98.556-92.292) epicondylar breadth was observed amongst the T2DM participant as  compared to the non-T2DM subjects. Conclusion: Our findings indicate a strong association between T2DM and anthropometric  parameters (skinfolds and body circumferences), thus, a risk factor in T2DM onset and its early prediction.     French title: Importance des  paramètres anthropométriques dans la prévalence du diabète de type 2-une étude de cas d'hôpitaux sélectionnés dans l'ouest de  l'Ouganda Le diabète est un groupe de troubles métaboliques caractérisés et identifiés par la présence d'une hyperglycémie en l'absence detraitement. Malgré la prise de conscience croissante du DT2 dans le monde et l'association stricte de sa prévalence croissante avec le  surpoids et l'obésité liés aux plis cutanés et à la circonférence du corps, l'incidence du DT2 et de ses diverses complications dévastatrices  continue d'augmenter en raison du manque de techniques auto-explorées pour le traiter, sa première prédiction. Le but de cette étude  était de déterminer la variation des paramètres anthropométriques en utilisant la valeur moyenne des circonférences corporelles, des  plis cutanés, de la largeur épicondylienne du
背景:糖尿病是一组新陈代谢紊乱疾病,其特点是在没有治疗的情况下出现高血糖。尽管全世界对 T2DM 的认识不断提高,而且 T2DM 的发病率与超重和肥胖的皮褶和体围密切相关,但由于缺乏自我探索的早期预测技术,T2DM 及其各种破坏性并发症的发病率仍在继续增加。本研究的目的是通过体围、皮褶、股骨外上髁宽和肱骨外上髁宽的平均值,确定乌干达西部两家选定的三甲医院的 T2DM 患者和非糖尿病患者的人体测量参数的变化。方法:研究对象包括 202 名成人,其中 101 名 2 型糖尿病成人(T2DM)和 101 名非糖尿病成人。按照国际运动促进学会(ISAK)的标准程序测量了身体(胸部、颈部、腰部、臀部、上臂、大腿和小腿)周长、皮褶(腹部、腋窝上部、腋窝中部、胸肌、肩胛下肌、大腿中部、小腿内侧和肱三头肌)和骨外髁宽度。结果:肱三头肌(21.581-12.331 毫米)、肩胛下肌(21.547-12.093 毫米)、肩胛上肌(20.573-8.240 毫米)、胸大肌(14.792-6.726 毫米)、中轴肌(20.573-8.240 毫米)、小腿内侧和肱三头肌(21.581-12.331 毫米)、肩胛下肌(21.547-12.093 毫米)、肩胛上肌(20.573-8.240 毫米)、胸大肌(14.792-6.726mm)、腋中(17.118-8.026mm)、腹部(24.648- 13.643mm)、小腿(23.217-13.171)、大腿中部(28.288-16.414)皮褶和上臂(33.231-27.482cm)、颈部(36.与非 T2DM 受试者相比,T2DM 受试者的上臂(33.231-27.482 厘米)、颈部(36.045-33.045 厘米)、小腿(40.100-34.417 厘米)、胸部(99.009-85.199 厘米)、臀部(113.176-94.265 厘米)、腰部(94.738-74.607 厘米)、大腿(60.939-50.543 厘米)周长以及肱骨(65.203-62.059)和股骨(98.556-92.292)髁上宽度均有所下降。结论:我们的研究结果表明,T2DM 与人体测量参数(皮褶和体围)之间存在密切联系,因此是 T2DM 发病及其早期预测的风险因素。 法文标题:Importance des paramètres anthropométriques dans la prévalence du diabète de type 2-une étude de cas d'hôpitaux sélectionnés dans l'ouest de l'Ouganda 糖尿病是一组代谢紊乱疾病,其特征和识别是在没有治疗的情况下出现高血糖。尽管全世界对 T2DM 的认识在不断提高,而且 T2DM 的发病率上升与超重和肥胖(与皮褶和体围有关)密切相关,但由于缺乏治疗 T2DM 的自我检测技术,T2DM 及其各种破坏性并发症的发病率仍在继续上升。本研究的目的是利用体围、皮褶、股骨外上髁宽度和肱骨外上髁宽度的平均值,确定西部地区两家选定的三级医院的 T2DM 患者和非糖尿病患者的人体测量参数的变化。乌干达。研究方法:研究对象包括 202 名成年人。101 名 2 型糖尿病 (T2DM) 成人和 101 名非糖尿病成人。采用国际运动测量促进会的标准程序测量了体围(胸围、颈围、腰围、臀围、上臂围、大腿围和小腿围)、皮褶(腹部皮褶、腋上皮褶、腋内侧皮褶、胸外侧皮褶、肩胛下皮褶、大腿中部皮褶、小腿内侧皮褶和肱三头肌皮褶)和上髁骨宽。(研究结果肱三头肌(21.581-12.331 毫米)、肩胛下肌(21.547- 12.093)、冈上肌(20.573-8.240 毫米)、胸大肌(14.792-6.726 毫米)、腋窝中肌(17.118-8、026 毫米)、腹部(24,648- 13,643 毫米)、小腿(23,217-13,171)、大腿中部(28,288-16,414)、皮褶和上臂(33,231-27,482 厘米)、颈部(36,045- 33,045 厘米)、小腿(40,100-34,417 厘米)、胸部。(与非 T2DM 受试者相比,T2DM 受试者的胸围(99.009-85.199 厘米)、臀围(113.176-94.265 厘米)、腰围(94.738-74.607 厘米)、大腿围(60.939-50.543 厘米)、肱骨外上髁围(65.203-62.059 厘米)和股骨围(98.556-92.292 厘米)的宽度均有所增加。结论:我们的研究结果表明,T2DM 与人体测量参数(皮肤褶皱和体围)之间存在密切联系,因此是 T2DM 发病及其早期预测的一个风险因素。
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引用次数: 0
Significance of anthropometric parameters in the prevalence of type 2 diabetes- a case study of selected hospitals in western Uganda 人体测量参数对 2 型糖尿病患病率的影响--乌干达西部部分医院的案例研究
Pub Date : 2024-02-12 DOI: 10.4314/rejhs.v12i1.7
O.O. Omoola, A.A. Tijani, A.A. Okesina, E.G. Anyanwu, U.M. Ibe
Background: Diabetes is a group of metabolic disorders characterized and identified by the presence of hyperglycaemia in the absence  of treatment. Despite the increasing awareness of T2DM in the world and strict association of its increasing prevalence with overweight  and obesity relating to skinfold and body circumferences, incidence of T2DM and its various devastating complications continues to be on  the increase because of lack of self-explored techniques for its early prediction. The purpose of this study was to determine variation  in the anthropometric parameters using the mean value of the body circumferences, skinfolds, epicondylar breadth of the femur and  epicondylar breadth of the humerus amongst T2DM patients at two selected tertiary hospitals and non-diabetic persons in Western  Uganda. Methods: The study was composed of 202 adults. 101 Type 2 diabetic adult (T2DM) and 101 non-diabetic adults. Body (chest,  neck, waist, hip, upper arm, thigh and calf) circumferences, skinfolds (abdominal, supraspinale, midaxillary, pectoralis, subscapularis,  mid-thigh, medial calf and triceps) and bony epicondylar breadth was measured following the standard procedure for The International  Society for the Advancement of Kinanthropometry (ISAK). Results: Significantly higher (<0.001) mean (triceps (21.581-12.331mm), subscapularis (21.547-12.093), supraspinale (20.573-8.240mm), pectoralis (14.792-6.726mm), mid-axillary (17.118-8.026mm), abdominal  (24.648- 13.643mm), calf (23.217-13.171), mid-thigh (28.288-16.414) skinfold and upper arm (33.231-27.482cm), neck (36.045-33.045cm),  calf (40.100-34.417cm), chest (99.009-85.199cm), hip (113.176-94.265cm), waist (94.738-74.607cm), thigh (60.939-50.543cm) circumference  as well as humeral (65.203-62.059) and femoral (98.556-92.292) epicondylar breadth was observed amongst the T2DM participant as  compared to the non-T2DM subjects. Conclusion: Our findings indicate a strong association between T2DM and anthropometric  parameters (skinfolds and body circumferences), thus, a risk factor in T2DM onset and its early prediction.     French title: Importance des  paramètres anthropométriques dans la prévalence du diabète de type 2-une étude de cas d'hôpitaux sélectionnés dans l'ouest de  l'Ouganda Le diabète est un groupe de troubles métaboliques caractérisés et identifiés par la présence d'une hyperglycémie en l'absence detraitement. Malgré la prise de conscience croissante du DT2 dans le monde et l'association stricte de sa prévalence croissante avec le  surpoids et l'obésité liés aux plis cutanés et à la circonférence du corps, l'incidence du DT2 et de ses diverses complications dévastatrices  continue d'augmenter en raison du manque de techniques auto-explorées pour le traiter, sa première prédiction. Le but de cette étude  était de déterminer la variation des paramètres anthropométriques en utilisant la valeur moyenne des circonférences corporelles, des  plis cutanés, de la largeur épicondylienne du
背景:糖尿病是一组新陈代谢紊乱疾病,其特点是在没有治疗的情况下出现高血糖。尽管全世界对 T2DM 的认识不断提高,而且 T2DM 的发病率与超重和肥胖的皮褶和体围密切相关,但由于缺乏自我探索的早期预测技术,T2DM 及其各种破坏性并发症的发病率仍在继续增加。本研究的目的是通过体围、皮褶、股骨外上髁宽和肱骨外上髁宽的平均值,确定乌干达西部两家选定的三甲医院的 T2DM 患者和非糖尿病患者的人体测量参数的变化。方法:研究对象包括 202 名成人,其中 101 名 2 型糖尿病成人(T2DM)和 101 名非糖尿病成人。按照国际运动促进学会(ISAK)的标准程序测量了身体(胸部、颈部、腰部、臀部、上臂、大腿和小腿)周长、皮褶(腹部、腋窝上部、腋窝中部、胸肌、肩胛下肌、大腿中部、小腿内侧和肱三头肌)和骨外髁宽度。结果:肱三头肌(21.581-12.331 毫米)、肩胛下肌(21.547-12.093 毫米)、肩胛上肌(20.573-8.240 毫米)、胸大肌(14.792-6.726 毫米)、中轴肌(20.573-8.240 毫米)、小腿内侧和肱三头肌(21.581-12.331 毫米)、肩胛下肌(21.547-12.093 毫米)、肩胛上肌(20.573-8.240 毫米)、胸大肌(14.792-6.726mm)、腋中(17.118-8.026mm)、腹部(24.648- 13.643mm)、小腿(23.217-13.171)、大腿中部(28.288-16.414)皮褶和上臂(33.231-27.482cm)、颈部(36.与非 T2DM 受试者相比,T2DM 受试者的上臂(33.231-27.482 厘米)、颈部(36.045-33.045 厘米)、小腿(40.100-34.417 厘米)、胸部(99.009-85.199 厘米)、臀部(113.176-94.265 厘米)、腰部(94.738-74.607 厘米)、大腿(60.939-50.543 厘米)周长以及肱骨(65.203-62.059)和股骨(98.556-92.292)髁上宽度均有所下降。结论:我们的研究结果表明,T2DM 与人体测量参数(皮褶和体围)之间存在密切联系,因此是 T2DM 发病及其早期预测的风险因素。 法文标题:Importance des paramètres anthropométriques dans la prévalence du diabète de type 2-une étude de cas d'hôpitaux sélectionnés dans l'ouest de l'Ouganda 糖尿病是一组代谢紊乱疾病,其特征和识别是在没有治疗的情况下出现高血糖。尽管全世界对 T2DM 的认识在不断提高,而且 T2DM 的发病率上升与超重和肥胖(与皮褶和体围有关)密切相关,但由于缺乏治疗 T2DM 的自我检测技术,T2DM 及其各种破坏性并发症的发病率仍在继续上升。本研究的目的是利用体围、皮褶、股骨外上髁宽度和肱骨外上髁宽度的平均值,确定西部地区两家选定的三级医院的 T2DM 患者和非糖尿病患者的人体测量参数的变化。乌干达。研究方法:研究对象包括 202 名成年人。101 名 2 型糖尿病 (T2DM) 成人和 101 名非糖尿病成人。采用国际运动测量促进会的标准程序测量了体围(胸围、颈围、腰围、臀围、上臂围、大腿围和小腿围)、皮褶(腹部皮褶、腋上皮褶、腋内侧皮褶、胸外侧皮褶、肩胛下皮褶、大腿中部皮褶、小腿内侧皮褶和肱三头肌皮褶)和上髁骨宽。(研究结果肱三头肌(21.581-12.331 毫米)、肩胛下肌(21.547- 12.093)、冈上肌(20.573-8.240 毫米)、胸大肌(14.792-6.726 毫米)、腋窝中肌(17.118-8、026 毫米)、腹部(24,648- 13,643 毫米)、小腿(23,217-13,171)、大腿中部(28,288-16,414)、皮褶和上臂(33,231-27,482 厘米)、颈部(36,045- 33,045 厘米)、小腿(40,100-34,417 厘米)、胸部。(与非 T2DM 受试者相比,T2DM 受试者的胸围(99.009-85.199 厘米)、臀围(113.176-94.265 厘米)、腰围(94.738-74.607 厘米)、大腿围(60.939-50.543 厘米)、肱骨外上髁围(65.203-62.059 厘米)和股骨围(98.556-92.292 厘米)的宽度均有所增加。结论:我们的研究结果表明,T2DM 与人体测量参数(皮肤褶皱和体围)之间存在密切联系,因此是 T2DM 发病及其早期预测的一个风险因素。
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