幽门螺杆菌 cag 致病岛是胃癌风险的决定因素。

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI:10.1080/19490976.2024.2314201
Sirena C Tran, Kaeli N Bryant, Timothy L Cover
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引用次数: 0

摘要

幽门螺杆菌菌株大致可分为两类,依据是它们是否含有被称为 cag 致病性岛(cag PAI)的染色体区域。与 cag PAI 阴性菌株相比,cag PAI 阳性菌株在人胃中的定植与胃癌和消化性溃疡病风险的增加有关。cag PAI 编码一种分泌型效应蛋白(CagA)和一种 IV 型分泌系统(Cag T4SS)的组成部分,该系统可将 CagA 和非蛋白底物送入宿主细胞。动物模型实验表明,CagA 和 Cag T4SS 会刺激胃粘膜炎症反应,并导致胃癌的发生。在这篇综述中,我们讨论了最近的一些研究,这些研究确定了 CagA 和 Cag T4SS 的结构和功能特征,以及含有 cag PAI 的幽门螺杆菌菌株促进胃癌和消化性溃疡病发展的机制。
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The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk.

Helicobacter pylori strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the cag pathogenicity island (cag PAI). Colonization of the human stomach with cag PAI-positive strains is associated with an increased risk of gastric cancer and peptic ulcer disease, compared to colonization with cag PAI-negative strains. The cag PAI encodes a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS) that delivers CagA and non-protein substrates into host cells. Animal model experiments indicate that CagA and the Cag T4SS stimulate a gastric mucosal inflammatory response and contribute to the development of gastric cancer. In this review, we discuss recent studies defining structural and functional features of CagA and the Cag T4SS and mechanisms by which H. pylori strains containing the cag PAI promote the development of gastric cancer and peptic ulcer disease.

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来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
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