幽门螺杆菌 cag 致病岛是胃癌风险的决定因素。

IF 12.2 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gut Microbes Pub Date : 2024-01-01 Epub Date: 2024-02-23 DOI:10.1080/19490976.2024.2314201
Sirena C Tran, Kaeli N Bryant, Timothy L Cover
{"title":"幽门螺杆菌 cag 致病岛是胃癌风险的决定因素。","authors":"Sirena C Tran, Kaeli N Bryant, Timothy L Cover","doi":"10.1080/19490976.2024.2314201","DOIUrl":null,"url":null,"abstract":"<p><p><i>Helicobacter pylori</i> strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the <i>cag</i> pathogenicity island (<i>cag</i> PAI). Colonization of the human stomach with <i>cag</i> PAI-positive strains is associated with an increased risk of gastric cancer and peptic ulcer disease, compared to colonization with <i>cag</i> PAI-negative strains. The <i>cag</i> PAI encodes a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS) that delivers CagA and non-protein substrates into host cells. Animal model experiments indicate that CagA and the Cag T4SS stimulate a gastric mucosal inflammatory response and contribute to the development of gastric cancer. In this review, we discuss recent studies defining structural and functional features of CagA and the Cag T4SS and mechanisms by which <i>H. pylori</i> strains containing the <i>cag</i> PAI promote the development of gastric cancer and peptic ulcer disease.</p>","PeriodicalId":12909,"journal":{"name":"Gut Microbes","volume":"16 1","pages":"2314201"},"PeriodicalIF":12.2000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10896142/pdf/","citationCount":"0","resultStr":"{\"title\":\"The <i>Helicobacter pylori cag</i> pathogenicity island as a determinant of gastric cancer risk.\",\"authors\":\"Sirena C Tran, Kaeli N Bryant, Timothy L Cover\",\"doi\":\"10.1080/19490976.2024.2314201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Helicobacter pylori</i> strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the <i>cag</i> pathogenicity island (<i>cag</i> PAI). Colonization of the human stomach with <i>cag</i> PAI-positive strains is associated with an increased risk of gastric cancer and peptic ulcer disease, compared to colonization with <i>cag</i> PAI-negative strains. The <i>cag</i> PAI encodes a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS) that delivers CagA and non-protein substrates into host cells. Animal model experiments indicate that CagA and the Cag T4SS stimulate a gastric mucosal inflammatory response and contribute to the development of gastric cancer. In this review, we discuss recent studies defining structural and functional features of CagA and the Cag T4SS and mechanisms by which <i>H. pylori</i> strains containing the <i>cag</i> PAI promote the development of gastric cancer and peptic ulcer disease.</p>\",\"PeriodicalId\":12909,\"journal\":{\"name\":\"Gut Microbes\",\"volume\":\"16 1\",\"pages\":\"2314201\"},\"PeriodicalIF\":12.2000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10896142/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gut Microbes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/19490976.2024.2314201\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/2/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gut Microbes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19490976.2024.2314201","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/23 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

幽门螺杆菌菌株大致可分为两类,依据是它们是否含有被称为 cag 致病性岛(cag PAI)的染色体区域。与 cag PAI 阴性菌株相比,cag PAI 阳性菌株在人胃中的定植与胃癌和消化性溃疡病风险的增加有关。cag PAI 编码一种分泌型效应蛋白(CagA)和一种 IV 型分泌系统(Cag T4SS)的组成部分,该系统可将 CagA 和非蛋白底物送入宿主细胞。动物模型实验表明,CagA 和 Cag T4SS 会刺激胃粘膜炎症反应,并导致胃癌的发生。在这篇综述中,我们讨论了最近的一些研究,这些研究确定了 CagA 和 Cag T4SS 的结构和功能特征,以及含有 cag PAI 的幽门螺杆菌菌株促进胃癌和消化性溃疡病发展的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk.

Helicobacter pylori strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the cag pathogenicity island (cag PAI). Colonization of the human stomach with cag PAI-positive strains is associated with an increased risk of gastric cancer and peptic ulcer disease, compared to colonization with cag PAI-negative strains. The cag PAI encodes a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS) that delivers CagA and non-protein substrates into host cells. Animal model experiments indicate that CagA and the Cag T4SS stimulate a gastric mucosal inflammatory response and contribute to the development of gastric cancer. In this review, we discuss recent studies defining structural and functional features of CagA and the Cag T4SS and mechanisms by which H. pylori strains containing the cag PAI promote the development of gastric cancer and peptic ulcer disease.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Gut Microbes
Gut Microbes Medicine-Microbiology (medical)
CiteScore
18.20
自引率
3.30%
发文量
196
审稿时长
10 weeks
期刊介绍: The intestinal microbiota plays a crucial role in human physiology, influencing various aspects of health and disease such as nutrition, obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and more. Gut Microbes serves as a platform for showcasing and discussing state-of-the-art research related to the microorganisms present in the intestine. The journal emphasizes mechanistic and cause-and-effect studies. Additionally, it has a counterpart, Gut Microbes Reports, which places a greater focus on emerging topics and comparative and incremental studies.
期刊最新文献
Candida tropicalis-derived vitamin B3 exerts protective effects against intestinal inflammation by promoting IL-17A/IL-22-dependent epithelial barrier function The role and mechanism of gut-lung axis mediated bidirectional communication in the occurrence and development of chronic obstructive pulmonary disease. Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells. Muropeptides and muropeptide transporters impact on host immune response. Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1