耶尔森氏菌的致病性和毒性。

IF 5.5 1区 农林科学 Q1 IMMUNOLOGY Virulence Pub Date : 2024-12-01 Epub Date: 2024-02-22 DOI:10.1080/21505594.2024.2316439
Jarett A Seabaugh, Deborah M Anderson
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引用次数: 0

摘要

耶尔森菌属包括人类、动物、昆虫和植物病原体以及许多共生菌和无害细菌。该属中有小肠结肠耶尔森菌和耶尔森菌假结核复合菌,其中有 4 种人类致病菌在基因组水平上高度相关,包括鼠疫的致病菌鼠疫耶尔森菌。为了了解这些病原体的基本致病机理和人畜共患传播途径,已经开展了广泛的实验室、实地工作和临床研究。目前有 500 多个全基因组序列,可以从中发现进化的足迹,详细说明共同和独特的毒力特性。目前,鼠疫耶尔森菌的毒力在其跳蚤传播周期中似乎处于明显的平衡状态,而影响传播和疾病严重性的实质性进化变化则在其他引起肠道疾病的耶尔森菌中继续受到明显的选择性压力。在这篇综述中,我们将总结目前对耶尔森菌毒力和致病机理的认识,强调共同的毒力机制以及决定感染生态位和疾病严重程度的差异。
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Pathogenicity and virulence of Yersinia.

The genus Yersinia includes human, animal, insect, and plant pathogens as well as many symbionts and harmless bacteria. Within this genus are Yersinia enterocolitica and the Yersinia pseudotuberculosis complex, with four human pathogenic species that are highly related at the genomic level including the causative agent of plague, Yersinia pestis. Extensive laboratory, field work, and clinical research have been conducted to understand the underlying pathogenesis and zoonotic transmission of these pathogens. There are presently more than 500 whole genome sequences from which an evolutionary footprint can be developed that details shared and unique virulence properties. Whereas the virulence of Y. pestis now seems in apparent homoeostasis within its flea transmission cycle, substantial evolutionary changes that affect transmission and disease severity continue to ndergo apparent selective pressure within the other Yersiniae that cause intestinal diseases. In this review, we will summarize the present understanding of the virulence and pathogenesis of Yersinia, highlighting shared mechanisms of virulence and the differences that determine the infection niche and disease severity.

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来源期刊
Virulence
Virulence IMMUNOLOGY-MICROBIOLOGY
CiteScore
9.20
自引率
1.90%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.
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