针对老年人肌肉疏松性肥胖和 3 年死亡率的身体成分评估：对比研究

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-02-23 DOI:10.1002/jpen.2613

Yavuz Sultan Selim Akgul MD, Sibel Akin MD, Burcu Eren Cengiz MD, Derya Kocaslan MD, Nurhayat Tugra Ozer PhD

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引用次数: 0

摘要

背景：肌肉疏松性肥胖（SO）没有公认的定义，其患病率也不明确。本研究旨在根据不同的定义调查老年人肌肉疏松性肥胖的患病率，并确定哪种定义可预测全因死亡率：这项前瞻性纵向随访研究纳入了年龄≥60 岁的门诊患者。SO是根据欧洲老年人肌肉疏松症工作组2（EWGSOP2）标准加上肥胖症定义的肌肉疏松症。肥胖的定义有三种不同的方法。体重指数（BMI）≥30 kg/m2，男性腰围≥102 cm，女性腰围≥88.0 cm，男性体脂率≥37.3%，女性体脂率≥51.1%。对SO的不同定义及其死亡率预测进行了比较：研究中 584 名患者的中位年龄为 70.0 岁（四分位距为 66.0-76.0 岁）。肌肉疏松症的发病率为 38.5%（男性为 47.5%，女性为 35.7%）。根据体重指数（BMI）、腹围（WC）和脂肪率（BF%）计算，肌肉疏松症的发病率分别为 15.3%、16.4% 和 10.5%。死亡率为 6.7%。在调整了年龄、性别和合并症数量等混杂变量后，基于体重指数（OR，2.73；95% CI，1.12-17.9；P = 0.024）和BF%（OR，1.43；95% CI，1.19-3.02；P = 0.007）的SO与3年死亡率显著相关。结论：基于腹围的 SO 与死亡率无关（OR，0.78；95% CI，0.07-1.27；P = 0.104）：结论：在门诊老年人中，使用BF%和BMI来定义SO是合适的。

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Body composition assessment for sarcopenic obesity and 3-year mortality in older adults: A comparison study

Background

There is no universally accepted definition of sarcopenic obesity (SO), and its prevalence is ambiguous. This study aimed to investigate the prevalence of SO in older adults based on different definitions and determine which predicts all-cause mortality.

Methods

This prospective longitudinal follow-up study included outpatients aged ≥60 years. SO was defined by sarcopenia definition based on the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria plus obesity. Three different methods were used to define obesity. Body mass index (BMI) ≥ 30 kg/m², waist circumference (WC) ≥ 102 cm for men and ≥88.0 cm for women, and body fat percentage (BF%) ≥ 37.3% for men and ≥51.1% for women. Different definitions of SO and their mortality predictions were compared.

Results

The median age of the 584 patients in the study was 70.0 (interquartile range, 66.0–76.0) years. The prevalence of sarcopenia was 38.5% (47.5% in men and 35.7% in women). The prevalence of SO based on BMI, WC, and BF% was 15.3%, 16.4%, and 10.5%, respectively. The mortality rate was 6.7%. SO based on BMI (odds ratio [OR], 2.73; 95% CI, 1.12–17.9; P = 0.024) and BF% (OR, 1.43; 95% CI, 1.19–3.02; P = 0.007) were significantly associated with 3-year mortality after adjusting for the confounding variables of age, sex, and number of comorbidities. SO based on WC was not associated with mortality (OR, 0.78; 95% CI, 0.07–1.27; P = 0.104).