GastroPanel 检测法与用 ABC 法解读的血清胃蛋白酶原检测法之间的比较--一项前瞻性研究。

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Helicobacter Pub Date : 2024-02-25 DOI:10.1111/hel.13056

Sun-Young Lee, Yeon-Sun Ahn, Hee-Won Moon

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引用次数: 0

摘要

背景与目的本研究旨在验证幽门螺杆菌血清学和胃蛋白酶原（PG）测定在检测感染和胃肿瘤方面的有效性：方法：纳入 2023 年 5 月至 9 月期间接受血清 Chorus 幽门螺杆菌和 HBI PG 检测的个人。GastroPanel 检测使用相同的血液样本。HBI检测结果采用ABC法，以胃体萎缩（PG I≤70纳克/毫升，I/II≤3）和晚期胃体萎缩（PG I≤30纳克/毫升，I/II≤2）为标准进行解释：结果：共分析了144名感染幽门螺杆菌的韩国人和184名未感染的韩国人。Chorus 检验（灵敏度 97.2%，特异性 89.1%）比 GastroPanel 检验（灵敏度 95.8%，特异性 86.4%）显示出更高的曲线下面积（0.993 vs. 0.972，p = 0.003）。使用 GastroSoft 应用程序，胃体萎缩组的胃肿瘤发病率最高（50%），其次是低酸输出组（25.8%）、幽门螺杆菌感染组（11.6%）和前胃萎缩组（9.1%）。正常胃酸分泌组和高胃酸分泌组没有胃肿瘤。采用 ABC 法，胃体萎缩组的胃肿瘤发病率最高（C 组和 D 组为 23.8%），其次是 B 组（12.3%）和 A 组（2.4%）。用GastroSoft解读的胃体萎缩与用ABC法解读的胃体萎缩的一致性较差（k = 0.225），而与晚期胃体萎缩的一致性极佳（k = 0.854）：结论：虽然 Chorus 检验比 GastroPanel 检验更准确，但两种检验都能通过检测萎缩或感染来区分高危人群。正常组和高胃酸排出组（GastroSoft 应用程序）都没有胃肿瘤，A 组（ABC 方法）的胃肿瘤发病率最低。与胃体萎缩相比，GastroSoft 应用程序确定的胃体萎缩与 ABC 方法确定的晚期胃体萎缩更为一致。

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Comparison between the GastroPanel test and the serum pepsinogen assay interpreted with the ABC method—A prospective study

Background and Aims

This study aimed to validate Helicobacter pylori serological and pepsinogen (PG) assays for detecting infection and gastric neoplasm.

Methods

Individuals who underwent serum Chorus H. pylori and HBI PG assays were included from May to September 2023. The GastroPanel test was performed using the same blood sample. HBI assay findings were interpreted with the ABC method using the criteria of corpus atrophy (PG I ≤ 70 ng/mL & I/II ≤3) and advanced corpus atrophy (PG I ≤ 30 ng/mL & I/II ≤2).

Results

A total of 144 H. pylori-infected and 184 non-infected Koreans were analyzed. The Chorus test (sensitivity 97.2%, specificity 89.1%) showed higher area under the curve (0.993 vs. 0.972, p = 0.003) than the GastroPanel test (sensitivity 95.8%, specificity 86.4%). Using the GastroSoft application, the incidence of gastric neoplasms was highest in the corpus atrophy group (50%), followed by the low acid-output (25.8%), H. pylori infection (11.6%), and antral atrophy (9.1%) groups. There were no gastric neoplasms in the normal and high acid output groups. Using the ABC method, the incidence of gastric neoplasms was highest in the corpus atrophy groups (23.8% in Groups C and D), followed by Group B (12.3%) and Group A (2.4%). Corpus atrophy interpreted with the GastroSoft showed poor agreement (k = 0.225) with corpus atrophy interpreted with the ABC method, whereas it showed excellent agreement (k = 0.854) with advanced corpus atrophy.

Conclusions

Although the Chorus test was more accurate than the GastroPanel test, both assays discriminated high-risk individuals by detecting atrophy or infection. There were no gastric neoplasms in the normal or high acid-output groups (GastroSoft application), and gastric neoplasm incidence was lowest in Group A (ABC method). Corpus atrophy determined by GastroSoft application is more consistent with advanced corpus atrophy determined by the ABC method than is corpus atrophy.

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.