RpoS 和细菌的一般应激反应。

IF 8 1区 生物学 Q1 MICROBIOLOGY Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-02-27 DOI:10.1128/mmbr.00151-22
Sophie Bouillet, Taran S Bauer, Susan Gottesman
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引用次数: 0

摘要

摘要一般应激反应(GSR)是细菌为适应和应对不断变化的环境而开发的一种广泛策略。一般应激反应由一种或多种应激同时诱导,也可在进入静止期时诱导,并导致保护细胞免受多种应激的整体反应。替代性 sigma 因子 RpoS 是大肠杆菌中 GSR 的核心调节因子,在大多数 γ-蛋白质细菌中都是保守的。在大肠杆菌中,RpoS 主要通过激活 RpoS 翻译和抑制 RpoS 蛋白水解而在营养缺乏和其他应激条件下被诱导。本综述包括我们在了解应激如何导致 RpoS 诱导方面的最新进展,以及试图确定 RpoS 依赖性基因和途径的最新研究摘要。
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RpoS and the bacterial general stress response.

SUMMARYThe general stress response (GSR) is a widespread strategy developed by bacteria to adapt and respond to their changing environments. The GSR is induced by one or multiple simultaneous stresses, as well as during entry into stationary phase and leads to a global response that protects cells against multiple stresses. The alternative sigma factor RpoS is the central GSR regulator in E. coli and conserved in most γ-proteobacteria. In E. coli, RpoS is induced under conditions of nutrient deprivation and other stresses, primarily via the activation of RpoS translation and inhibition of RpoS proteolysis. This review includes recent advances in our understanding of how stresses lead to RpoS induction and a summary of the recent studies attempting to define RpoS-dependent genes and pathways.

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来源期刊
CiteScore
18.80
自引率
0.80%
发文量
27
期刊介绍: Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.
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