钠-葡萄糖共转运体-2 抑制剂的全身和器官特异性抗炎作用。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-05-01 Epub Date: 2024-02-29 DOI:10.1016/j.tem.2024.02.003
Mona Mashayekhi, Bilgunay Ilkin Safa, Matthew S C Gonzalez, Sangwon F Kim, Justin B Echouffo-Tcheugui
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引用次数: 0

摘要

炎症在许多慢性疾病的发病机制中起着至关重要的作用,也是其共同特征。钠-葡萄糖共转运体-2(SGLT2)抑制剂实现其备受赞誉的临床疗效的确切机制在很大程度上仍不为人所知。在这篇综述中,我们利用动物和人体研究的证据,详细介绍了 SGLT2 抑制剂的全身性和组织或器官特异性抗炎作用。我们讨论了 SGLT2 抑制剂发挥抗炎作用的潜在途径,包括氧化应激、线粒体和炎性体途径。最后,我们强调有必要在临床研究中进一步调查 SGLT2 抑制剂的抗炎作用对改善心脏代谢和肾脏预后的贡献程度。
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Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors.

Inflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal and human studies. We discuss the potential pathways through which SGLT2 inhibitors exert their anti-inflammatory effects, including oxidative stress, mitochondrial, and inflammasome pathways. Finally, we highlight the need for further investigation of the extent of the contribution of the anti-inflammatory effects of SGLT2 inhibition to improvements in cardiometabolic and renal outcomes in clinical studies.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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