线粒体是癌症进展的关键调控因素:关于突变、线粒体动力学和治疗方法的现有概念。

IF 6.4 2区 医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2024-01-01 DOI:10.1016/j.mrrev.2024.108490
Sraddhya Roy , Ananya Das , Aparajita Bairagi , Debangshi Das , Ashna Jha , Amit Kumar Srivastava , Nabanita Chatterjee
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引用次数: 0

摘要

在包括癌症在内的几乎所有疾病中,都可以观察到线粒体功能与功能障碍的不同影响。线粒体在细胞平衡和完整性方面发挥着至关重要的作用;然而,受 mtDNA 改变影响的线粒体功能障碍会破坏细胞平衡。许多导致细胞完整性异常的外部刺激或细胞缺陷也会影响线粒体功能。线粒体活性失衡可引发和导致基因突变的积累,并可促进肿瘤的发生、发展和存活过程。本综述总结了影响线粒体功能的表观遗传和基因改变,并考虑了细胞新陈代谢以及种族的影响。我们还综述了线粒体动力学、miRNA、在促进癌症发展中发挥关键作用的外泌体以及线粒体动力学对免疫细胞机制的影响等方面的最新研究成果。综述还总结了最近在抗癌治疗策略中针对线粒体的治疗方法。
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Mitochondria act as a key regulatory factor in cancer progression: Current concepts on mutations, mitochondrial dynamics, and therapeutic approach

The diversified impacts of mitochondrial function vs. dysfunction have been observed in almost all disease conditions including cancers. Mitochondria play crucial roles in cellular homeostasis and integrity, however, mitochondrial dysfunctions influenced by alterations in the mtDNA can disrupt cellular balance. Many external stimuli or cellular defects that cause cellular integrity abnormalities, also impact mitochondrial functions. Imbalances in mitochondrial activity can initiate and lead to accumulations of genetic mutations and can promote the processes of tumorigenesis, progression, and survival. This comprehensive review summarizes epigenetic and genetic alterations that affect the functionality of the mitochondria, with considerations of cellular metabolism, and as influenced by ethnicity. We have also reviewed recent insights regarding mitochondrial dynamics, miRNAs, exosomes that play pivotal roles in cancer promotion, and the impact of mitochondrial dynamics on immune cell mechanisms. The review also summarizes recent therapeutic approaches targeting mitochondria in anti-cancer treatment strategies.

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来源期刊
CiteScore
12.20
自引率
1.90%
发文量
22
审稿时长
15.7 weeks
期刊介绍: The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.
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