基于人参皂甙药代动力学特性的高丽参代谢和药物相互作用:现状与未来展望

IF 6.8 2区 医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2024-03-04 DOI:10.1016/j.jgr.2024.02.003
Jong Dae Park
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引用次数: 0

摘要

研究表明,口服人参皂甙是人参的主要活性成分,在胃肠道和肝脏中会被胃液、消化酶和细菌酶生物转化为多种代谢物。人参的药代动力学研究需要进一步澄清,以便更好地了解其安全性和临床应用的可能活性机制。实验结果表明,人参皂苷代谢物在药物代谢酶和药物转运体等药代动力学特性中发挥着重要作用,因此可作为代谢调节剂应用。很少有人知道,如果按推荐剂量服用人参,检测到的人参皂苷与真正的活性代谢物是否一致,但在任何临床试验中,都发现它们会对药代动力学的关键因素产生作用,影响口服生物利用度。由于人参的服用方式越来越多地与处方药联系在一起,因此也对人参与药物的相互作用进行了研究。考虑到人参的广泛口服,本综述旨在全面概述和展望最近有关人参皂甙药代动力学特性的研究,如脱糖、吸收、代谢酶和转运体,以及人参皂甙与药物的相互作用。
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Metabolism and drug interactions of Korean ginseng based on the pharmacokinetic properties of ginsenosides: Current status and future perspectives

Orally administered ginsenosides, the major active components of ginseng, have been shown to be biotransformed into a number of metabolites by gastric juice, digestive and bacterial enzymes in the gastrointestinal tract and also in the liver. Attention is brought to pharmacokinetic studies of ginseng that need further clarification to better understand the safety and possible active mechanism for clinical application. Experimental results demonstrated that ginsenoside metabolites play an important role in the pharmacokinetic properties such as drug metabolizing enzymes and drug transporters, thereby can be applied as a metabolic modulator. Very few are known on the possibility of the consistency of detected ginsenosides with real active metabolites if taken the recommended dose of ginseng, but they have been found to act on the pharmacokinetic key factors in any clinical trial, affecting oral bioavailability. Since ginseng is increasingly being taken in a manner more often associated with prescription medicines, ginseng and drug interactions have been also reviewed. Considering the extensive oral administration of ginseng, the aim of this review is to provide a comprehensive overview and perspectives of recent studies on the pharmacokinetic properties of ginsenosides such as deglycosylation, absorption, metabolizing enzymes and transporters, together with ginsenoside and drug interactions.

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来源期刊
Journal of Ginseng Research
Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE
CiteScore
11.40
自引率
9.50%
发文量
111
审稿时长
6-12 weeks
期刊介绍: Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.
期刊最新文献
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