Hui Yao , Ying Shen , Zhichao Liang , Xiaoyu Xue , Chenxi Zhao , Xiang Xu , Yuxin Cai , Yonghong Liu , Wei Zhang , Yang Pan , Xiaoli Wang
{"title":"中国唾液样本检测SARS-CoV-2的优越性和可接受性","authors":"Hui Yao , Ying Shen , Zhichao Liang , Xiaoyu Xue , Chenxi Zhao , Xiang Xu , Yuxin Cai , Yonghong Liu , Wei Zhang , Yang Pan , Xiaoli Wang","doi":"10.1016/j.bsheal.2024.03.002","DOIUrl":null,"url":null,"abstract":"<div><p>In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.0 %, the specificities were 92.6 % and 93.8 %, respectively. The results of an acceptability survey showed that the scores for saliva, OP, and NP samples were 9.46 ± 1.69, 8.11 ± 2.42, and 4.58 ± 3.82 out of 10, respectively, with significant differences among the three groups (<em>P</em> < 0.05). With higher sensitivity, comparable specificity, and strong public preference, saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics.</p></div>","PeriodicalId":36178,"journal":{"name":"Biosafety and Health","volume":"6 2","pages":"Pages 88-91"},"PeriodicalIF":3.5000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590053624000296/pdfft?md5=a78827afb1cb1971b20cf4587dca5a81&pid=1-s2.0-S2590053624000296-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China\",\"authors\":\"Hui Yao , Ying Shen , Zhichao Liang , Xiaoyu Xue , Chenxi Zhao , Xiang Xu , Yuxin Cai , Yonghong Liu , Wei Zhang , Yang Pan , Xiaoli Wang\",\"doi\":\"10.1016/j.bsheal.2024.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.0 %, the specificities were 92.6 % and 93.8 %, respectively. The results of an acceptability survey showed that the scores for saliva, OP, and NP samples were 9.46 ± 1.69, 8.11 ± 2.42, and 4.58 ± 3.82 out of 10, respectively, with significant differences among the three groups (<em>P</em> < 0.05). With higher sensitivity, comparable specificity, and strong public preference, saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics.</p></div>\",\"PeriodicalId\":36178,\"journal\":{\"name\":\"Biosafety and Health\",\"volume\":\"6 2\",\"pages\":\"Pages 88-91\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2590053624000296/pdfft?md5=a78827afb1cb1971b20cf4587dca5a81&pid=1-s2.0-S2590053624000296-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosafety and Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590053624000296\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosafety and Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590053624000296","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China
In response to problems of poor sampling quality, low sensitivity, and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) oropharyngeal (OP) swab sampling used in China, we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests (NAATs) in China. The results showed that, using nasopharyngeal (NP) swab results as the gold standard, the overall sensitivities for saliva specimens and OP swabs were 93.3 % and 85.0 %, the specificities were 92.6 % and 93.8 %, respectively. The results of an acceptability survey showed that the scores for saliva, OP, and NP samples were 9.46 ± 1.69, 8.11 ± 2.42, and 4.58 ± 3.82 out of 10, respectively, with significant differences among the three groups (P < 0.05). With higher sensitivity, comparable specificity, and strong public preference, saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
