室内空气净化器对日托中心感染控制的影响

Ville A. Vartiainen , Johanna Hela , Anni Luoto , Petra Nikuri , Enni Sanmark , Aimo Taipale , Inga Ehder-Gahm , Natalia Lastovets , Piia Sormunen , Ilpo Kulmala , Arto Säämänen
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引用次数: 0

摘要

本研究的目的是利用一个简单而稳健的计算模型,评估空气净化在降低两家日托中心呼吸道感染风险方面的效果。此外,我们还旨在确定室内环境中潜在的感染热点,并有针对性地采取对策。我们提供了一项干预性临床研究的初步结果,作为该模型的概念验证。我们构建了一个数学模型,用于评估日托机构中面临空气传播感染风险的人数。利用该模型,我们在两个日托单位(A 和 B,参与研究的儿童人数 n = 43)中使用了便携式空气净化器,并将两个干预单位与赫尔辛基市其他单位(n = 607)的感染事件进行了比较。干预建筑采用机械送排风系统。风险模型显示,使用空气净化器后,感染传播风险的预期人数明显减少。日托中心 A 的平均减少率为 60%(范围为 52% - 88%),日托中心 B 为 53%(范围为 14% - 59%)。在大约 6 个月的研究期间,我们观察到干预日托中心和参照日托中心因感染而缺勤的天数有显著差异。在研究期间,参照日托中心的父母因孩子生病而缺勤的天数平均为 5.53 天,而干预日托中心的父母因孩子生病而缺勤的天数平均为 3.77 天(P=0.009)。相对而言,减少了约 32%。我们的研究提供了令人信服的证据,支持在需要进行感染风险管理期间提高日托中心的非感染性空气流速。这可以通过便携式空气净化器来实现,是一种有效且具有成本效益的策略,可以减少呼吸道感染在儿童中的传播。意义和影响--空气清洁似乎是降低日托中心感染风险的有效方法--确定感染风险热点有助于设计预防方法--便携式空气清洁器为现有通风设备不足以进行感染风险管理的建筑提供了经济实惠的多功能解决方案"。
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The effect of room air cleaners on infection control in day care centres

The aim of this study was to assess the effectiveness of air cleaning in reducing the risk of respiratory infection in two day care centres using a simple and robust calculation model. Additionally, we aimed to identify potential hotspots for infections in indoor setting and focus countermeasures accordingly. Initial results from an interventional clinical study are provided as proof-of-concept for the model. We constructed a mathematical model to assess the number of persons at risk for airborne infection transmission in day care. Utilizing the model, we used portable air cleaners in two day care units (A and B, number of children participating in the study n = 43) and compared infection incidents between the two intervention units to the rest of the units in city of Helsinki (n = 607). The intervention buildings had mechanical supply and exhaust air ventilation. The risk modelling suggests that the use of air cleaners reduced the expected number of persons at infection transmission risk significantly. At day care centre A the average reduction was 60% (range 52% - 88%) and at day care centre B 53% (range 14% - 59%). During the approximately six month study period, we observed a significant difference in the days absent from day care due to infections between the intervention and reference day care units. On average, the parents were absent from work due to child’s illness in reference day care centers for 5.53 days and 3.77 days in intervention day care centers during the study period (p=0.009). In relative terms the reduction was approximately 32%. Our study offers compelling evidence to support increasing non-infectious air flow rates in daycare centers during periods requiring infection risk management. This can be implemented with portable air cleaners as an effective and cost-efficient strategy for mitigating the spread of respiratory infections among children. The clinical results support the findings suggested by the theoretical model.

Implications and impacts

  • Air cleaning seems to be an effective way to reduce infection risk in day cares

  • Identification of infection risk hotspot will help in desgining the preventive methods

  • Portable air cleaners offer an affordable and versatile solution also in buildings where existing ventilation is insufficient for infection risk management”

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