微孢子虫与微生物组其他成员之间的相互作用。

IF 2.1 4区 生物学 Q3 MICROBIOLOGY Journal of Eukaryotic Microbiology Pub Date : 2024-04-01 DOI:10.1111/jeu.13025
Jonathan Tersigni, Hala Tamim El Jarkass, Edward B. James, Aaron W. Reinke
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引用次数: 0

摘要

微生物组是与宿主相关的微生物的集合。微孢子虫是细胞内真核寄生虫,可感染大多数类型的动物。近十年来,在确定微孢子虫与微生物组之间的关系方面取得了很大进展。在这篇综述中,我们将介绍越来越多的报道,这些报道表明微孢子虫是无脊椎动物和脊椎动物微生物组的常见组成部分。这些微孢子虫感染的范围从互利性到致病性不等,可导致多种生理表型,包括死亡。感染小孢子虫通常会破坏正常的微生物群,观察到细菌、真菌、病毒和原生动物物种的增加和减少。这种对微生物群的影响可通过先天性免疫的上调和下调以及组织的形态变化来实现,从而影响与这些微生物的相互作用。其他微生物,尤其是细菌,可以抑制微孢子虫,并被用来控制微孢子虫感染。这些细菌可以通过调节免疫力、分泌抗小孢子虫化合物,以及在工程化版本中表达靶向小孢子虫基因的双链 RNA 来发挥作用。在本综述的最后,我们讨论了进一步了解微孢子虫与微生物组其他成员之间复杂相互作用的潜在未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Interactions between microsporidia and other members of the microbiome

The microbiome is the collection of microbes that are associated with a host. Microsporidia are intracellular eukaryotic parasites that can infect most types of animals. In the last decade, there has been much progress to define the relationship between microsporidia and the microbiome. In this review, we cover an increasing number of reports suggesting that microsporidia are common components of the microbiome in both invertebrates and vertebrates. These microsporidia infections can range from mutualistic to pathogenic, causing several physiological phenotypes, including death. Infection with microsporidia often causes a disruption in the normal microbiome, with both increases and decreases of bacterial, fungal, viral, and protozoan species being observed. This impact on the microbiome can occur through upregulation and downregulation of innate immunity as well as morphological changes to tissues that impact interactions with these microbes. Other microbes, particularly bacteria, can inhibit microsporidia and have been exploited to control microsporidia infections. These bacteria can function through regulating immunity, secreting anti-microsporidia compounds, and, in engineered versions, expressing double-stranded RNA targeting microsporidia genes. We end this review by discussing potential future directions to further understand the complex interactions between microsporidia and the other members of the microbiome.

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来源期刊
CiteScore
4.30
自引率
4.50%
发文量
85
审稿时长
6-12 weeks
期刊介绍: The Journal of Eukaryotic Microbiology publishes original research on protists, including lower algae and fungi. Articles are published covering all aspects of these organisms, including their behavior, biochemistry, cell biology, chemotherapy, development, ecology, evolution, genetics, molecular biology, morphogenetics, parasitology, systematics, and ultrastructure.
期刊最新文献
Katarium polorum n. sp., n. g., a novel thecofilosean amoeba (Cercozoa, Rhizaria) from the polar oceans. Issue Information Editorial Acknowledgment Retention of blue-green cryptophyte organelles by Mesodinium rubrum and their effects on photophysiology and growth. Effect of protease inhibitors on the intraerythrocytic development of Babesia microti and Babesia duncani, the causative agents of human babesiosis.
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