{"title":"在无金属和无溶剂条件下以可回收离子液体为媒介合成喹唑啉-4(3H)-酮类化合物","authors":"Xue Ma, Peng Li, Xuerou Chen, Siqi Li, Wuji Sun, Qidi Zhong","doi":"10.1016/j.giant.2024.100255","DOIUrl":null,"url":null,"abstract":"<div><p>A metal-free and solvent-free method for the synthesis of quinazolin-4(3<em>H</em>)-ones is proposed by condensation cyclization of 2-aminobenzamides and aldehydes using 1-butyl-3-methylimida-zolium tetrafluoride ([Bmim]BF<sub>4</sub>) as ionic liquid catalyst. In this reaction, [Bmim]BF<sub>4</sub> acts as both a catalyst and a solvent without need for additional catalysts and solvents. This method exhibits favorable functional group tolerance in substrates and affords a series of desired products in moderate to excellent yields. In addition, it is noteworthy that the reaction yield is still as high as 87% after [Bmim]BF<sub>4</sub> is recycled at least four times.</p></div>","PeriodicalId":34151,"journal":{"name":"GIANT","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666542524000201/pdfft?md5=cb66995979f1c6c7d115a4402a2e6423&pid=1-s2.0-S2666542524000201-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Recyclable ionic liquid-mediated synthesis of quinazolin-4(3H)-ones under metal-free and solvent-free conditions\",\"authors\":\"Xue Ma, Peng Li, Xuerou Chen, Siqi Li, Wuji Sun, Qidi Zhong\",\"doi\":\"10.1016/j.giant.2024.100255\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A metal-free and solvent-free method for the synthesis of quinazolin-4(3<em>H</em>)-ones is proposed by condensation cyclization of 2-aminobenzamides and aldehydes using 1-butyl-3-methylimida-zolium tetrafluoride ([Bmim]BF<sub>4</sub>) as ionic liquid catalyst. In this reaction, [Bmim]BF<sub>4</sub> acts as both a catalyst and a solvent without need for additional catalysts and solvents. This method exhibits favorable functional group tolerance in substrates and affords a series of desired products in moderate to excellent yields. In addition, it is noteworthy that the reaction yield is still as high as 87% after [Bmim]BF<sub>4</sub> is recycled at least four times.</p></div>\",\"PeriodicalId\":34151,\"journal\":{\"name\":\"GIANT\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-03-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2666542524000201/pdfft?md5=cb66995979f1c6c7d115a4402a2e6423&pid=1-s2.0-S2666542524000201-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"GIANT\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666542524000201\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"GIANT","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666542524000201","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Recyclable ionic liquid-mediated synthesis of quinazolin-4(3H)-ones under metal-free and solvent-free conditions
A metal-free and solvent-free method for the synthesis of quinazolin-4(3H)-ones is proposed by condensation cyclization of 2-aminobenzamides and aldehydes using 1-butyl-3-methylimida-zolium tetrafluoride ([Bmim]BF4) as ionic liquid catalyst. In this reaction, [Bmim]BF4 acts as both a catalyst and a solvent without need for additional catalysts and solvents. This method exhibits favorable functional group tolerance in substrates and affords a series of desired products in moderate to excellent yields. In addition, it is noteworthy that the reaction yield is still as high as 87% after [Bmim]BF4 is recycled at least four times.
期刊介绍：
Giant is an interdisciplinary title focusing on fundamental and applied macromolecular science spanning all chemistry, physics, biology, and materials aspects of the field in the broadest sense. Key areas covered include macromolecular chemistry, supramolecular assembly, multiscale and multifunctional materials, organic-inorganic hybrid materials, biophysics, biomimetics and surface science. Core topics range from developments in synthesis, characterisation and assembly towards creating uniformly sized precision macromolecules with tailored properties, to the design and assembly of nanostructured materials in multiple dimensions, and further to the study of smart or living designer materials with tuneable multiscale properties.
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