土耳其首个多学科基因治疗教育计划:历史与未来计划

Merve Koç Yekedüz, Engin Köse, Ömer Erdeve, F. T. Eminoğlu
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摘要

背景:基因疗法用于调节人体细胞中突变或致病基因的功能,以核苷酸为靶点。近年来,越来越多的出版物报道了基因疗法的成功结果,这表明临床医生对基因疗法的科学好奇心越来越强。方法:基因疗法研讨会由[盲审]主办。与会者回答了前后测试和满意度量表。结果:共有 192 人参加了培训,其中没有人以前接受过基因治疗培训。在样本中,71.9%为女性,参与者的年龄中位数为 32 岁。在所有参与者中,84.9%是医学专业学生,15.1%是非医学专业学生。在学医的人中,17.2% 是学生,18.4% 是主要专业研究助理,38.0% 是亚专业研究助理,17.2% 是专家,9.2% 是助理教授/教授。对已完成的预测试进行分析后发现,32.3%的人正确回答了问题,58.6%的人在接受培训后正确回答了问题。总体满意度为 91.8 分(满分 100 分)。结论:预测试结果显示,参与者对基因疗法的了解和认识程度较低,这表明有必要针对这一主题开展教育计划。近年来,基因治疗已超越了理论范畴,如今已开始实际应用。目前急需培训临床医生和提供基因疗法所需的其他操作人员,并为三级医疗中心制定未来 10 年在该领域的发展战略。
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Türkiye’s First Multidisciplinary Gene Therapy Education Program: History and Plans for the Future
Background: Gene therapy is applied to regulate the functions of mutated or disease-causing genes in human cells and targets nucleotides. Recent years have seen an increasing number of publications reporting successful results from gene therapies, suggesting an increasing scientific curiosity among clinicians. Methods: Gene Therapy Symposiums were hosted by the [blinded for review]. The participants answered pre-post-tests, and satisfaction scales. Results: A total of 192 participants underwent training, none of whom had previously undergone gene therapy training. Of the sample, 71.9% were female and the median age of the participants was 32 years. Of the total, 84.9% were studying medicine and 15.1% were studying in non-medical fields. Among those studying medicine, 17.2% were students, 18.4% were main specialty research assistants, 38.0% were subspecialty research assistants, 17.2% were specialists and 9.2% were assistant professors/professors. An analysis of the completed pretests revealed that 32.3% had answered the questions correctly, while 58.6% answered the questions correctly after undergoing training. The overall satisfaction score was 91.8 out of 100. Conclusions: The results of the pretest revealed the knowledge and awareness of gene therapy among the participants to be low, indicating a need for education programs addressing the subject. Gene therapy has moved beyond the theoretical realm in recent years and is today seeing practical applications. There is an urgent need to train the clinicians and other operatives required for the provision of gene therapies and to develop strategies for tertiary care centers in this field over the next 10 years.
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