Zeynep Pelin Dündar, N. Kafa, Neslihan Alkan Durutürk, H. Vatansev, Adil Zamani
ABSTRACT Aim: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication of COPD and a leading cause of hospitalization, detrimentally affecting functional exercise capacity. The 6-minute walk test (6MWT) is a reliable measure of exercise capacity in chronic lung diseases. Conversely, the 1-minute sit-to-stand test (1STST) offers a simpler assessment of physical function. The aim was to demonstrate the association of functional exercise capacity assessed by 1STST and 6MWT in COPD patients with acute exacerbation. Materials and Methods: In this study, 37 hospitalized patients with acute exacerbation COPD (mean age:66 years) underwent assessments including pulmonary function testing, 6MWT, 1STST and modified Medical Research Council (MMRC). Parameters such as heart rate, oxygen saturation, and perceived dyspnea (via the modified Borg scale) were monitored during tests. Results: The results showed a significant correlation between 6MWT and 1STST performance (r=0.656, p<0.001). Notably, end-tidal oxygen saturation differed between tests, with the 6MWT showing higher end-tidal dyspnea scores. During recovery, 1STST induced increased heart rate and decreased oxygen saturation. Both 6MWT and 1STST were negatively associated with age and MMRC. Positive correlations were observed between 6MWT and FEV1(L) and PEF(L). Conclusions: Similar to the 6MWT, the 1STS test may be used to evaluate how well patients with AECOPD perform during functional exercise. We propose that the 1STST is a suitable alternative to the 6MWT for the assessment of functional exercise performance during hospitalization in AECOPD patients.
{"title":"The association between six-minute walk test and one minute sit to stand test in patients with acute exacerbations of COPD","authors":"Zeynep Pelin Dündar, N. Kafa, Neslihan Alkan Durutürk, H. Vatansev, Adil Zamani","doi":"10.16899/jcm.1470332","DOIUrl":"https://doi.org/10.16899/jcm.1470332","url":null,"abstract":"ABSTRACT\u0000Aim: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication of COPD and a leading cause of hospitalization, detrimentally affecting functional exercise capacity. The 6-minute walk test (6MWT) is a reliable measure of exercise capacity in chronic lung diseases. Conversely, the 1-minute sit-to-stand test (1STST) offers a simpler assessment of physical function. The aim was to demonstrate the association of functional exercise capacity assessed by 1STST and 6MWT in COPD patients with acute exacerbation.\u0000Materials and Methods: In this study, 37 hospitalized patients with acute exacerbation COPD (mean age:66 years) underwent assessments including pulmonary function testing, 6MWT, 1STST and modified Medical Research Council (MMRC). Parameters such as heart rate, oxygen saturation, and perceived dyspnea (via the modified Borg scale) were monitored during tests.\u0000Results: The results showed a significant correlation between 6MWT and 1STST performance (r=0.656, p<0.001). Notably, end-tidal oxygen saturation differed between tests, with the 6MWT showing higher end-tidal dyspnea scores. During recovery, 1STST induced increased heart rate and decreased oxygen saturation. Both 6MWT and 1STST were negatively associated with age and MMRC. Positive correlations were observed between 6MWT and FEV1(L) and PEF(L).\u0000Conclusions: Similar to the 6MWT, the 1STS test may be used to evaluate how well patients with AECOPD perform during functional exercise. We propose that the 1STST is a suitable alternative to the 6MWT for the assessment of functional exercise performance during hospitalization in AECOPD patients.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":"66 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140976293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Aim: Effective and correct use of terminology in anatomy education and other medical sciences is very important for healthy communication between scientists. Due to the low number of scientific studies on both medical and anatomical terminology, this study was conducted to help increase the existing knowledge in this field. Material and Method: Terminologia Anatomica, published by Thieme in 1998, was used in the study. Results: A total of 2431 terms related to the nervous system and sensory organs were analyzed, and a total of 625 different adjectives within these terms were evaluated in terms of origin, degree and form and classified into classes. A total of 492 different adjectives were included in the 1924 terms under the title of nervous system. There are 133 different adjectives in 507 terms under the title of sense organs. There are a total of 2753 adjectives in both sections we have analyzed, together with the number of repetitions. It was observed that most of these adjectives were of Latin origin, two-shaped and had a gradus positivus degree of comparison. Discussion: The data we obtained as a result of this study revealed the distribution and characteristics of adjectives in terms of origin, degree and form within the terminology. We think that our study will contribute to the development of medical terminology and will also help make the anatomy course more understandable and memorable for students.
{"title":"INVESTIGATION OF THE ADJECTIVES IN TERMINOLOGIA ANATOMICA, IN TERMS RELATED TO THE NERVOUS SYSTEM AND SENSE ORGANS","authors":"Mücahit Aydın, Hilal Irmak Sapmaz","doi":"10.16899/jcm.1454025","DOIUrl":"https://doi.org/10.16899/jcm.1454025","url":null,"abstract":"ABSTRACT \u0000 \u0000Aim: Effective and correct use of terminology in anatomy education and other medical sciences is very important for healthy communication between scientists. Due to the low number of scientific studies on both medical and anatomical terminology, this study was conducted to help increase the existing knowledge in this field. \u0000 \u0000Material and Method: Terminologia Anatomica, published by Thieme in 1998, was used in the study. \u0000 \u0000Results: A total of 2431 terms related to the nervous system and sensory organs were analyzed, and a total of 625 different adjectives within these terms were evaluated in terms of origin, degree and form and classified into classes. A total of 492 different adjectives were included in the 1924 terms under the title of nervous system. There are 133 different adjectives in 507 terms under the title of sense organs. There are a total of 2753 adjectives in both sections we have analyzed, together with the number of repetitions. It was observed that most of these adjectives were of Latin origin, two-shaped and had a gradus positivus degree of comparison. \u0000 \u0000Discussion: The data we obtained as a result of this study revealed the distribution and characteristics of adjectives in terms of origin, degree and form within the terminology. We think that our study will contribute to the development of medical terminology and will also help make the anatomy course more understandable and memorable for students.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":" 1188","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140989091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Smoking is a chronic disease and children are the most affected group. In this study, we aimed to question the smoking habits of children and their parents and examine the level of exhaled carbon monoxide (eCO) to evaluate the usefulness of the method in an outpatient allergy clinic. Methods: A questionnare was applied to 29 children who were smoker or exposed to second-hand smoke (SHS) and their parents separately. eCO levels of the participants were measured with CO Smokerlyzer. Results: The median eCO level of children who smoked was 10 (7-14) ppm and was significantly higher than children exposed to SHS (P <0.001). The children who smoked were significantly older, the more they had friends who smoked. Children who were not exposed to tobacco products had lower rates of hospitalization due to recurrent lower respiratory tract infections, and family history of asthma was lower than children exposed to SHS (p <0.05). All the children were aware of the harmful effects of smoking. 34.5% of the parents were never questioned by their physicians about tobacco and its products and were not informed about smoking. Conclusions: Using eCO in the clinic is a useful method to predict smoking status in daily practice. Children's attitudes towards smoking and peer relationships and parents' ignorance of smoking and SHS are still an unresolved issue.
{"title":"Smoking and Real Life Results of Children and Adolescents","authors":"A. Ertuğrul, Eyüp Sarı, İlknur Bostancı","doi":"10.16899/jcm.873009","DOIUrl":"https://doi.org/10.16899/jcm.873009","url":null,"abstract":"Aim: Smoking is a chronic disease and children are the most affected group. In this study, we aimed to question the smoking habits of children and their parents and examine the level of exhaled carbon monoxide (eCO) to evaluate the usefulness of the method in an outpatient allergy clinic.\u0000Methods: A questionnare was applied to 29 children who were smoker or exposed to second-hand smoke (SHS) and their parents separately. eCO levels of the participants were measured with CO Smokerlyzer.\u0000Results: The median eCO level of children who smoked was 10 (7-14) ppm and was significantly higher than children exposed to SHS (P <0.001). The children who smoked were significantly older, the more they had friends who smoked. Children who were not exposed to tobacco products had lower rates of hospitalization due to recurrent lower respiratory tract infections, and family history of asthma was lower than children exposed to SHS (p <0.05). All the children were aware of the harmful effects of smoking. 34.5% of the parents were never questioned by their physicians about tobacco and its products and were not informed about smoking.\u0000Conclusions: Using eCO in the clinic is a useful method to predict smoking status in daily practice. Children's attitudes towards smoking and peer relationships and parents' ignorance of smoking and SHS are still an unresolved issue.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":"31 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140368320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: The aim of this study was to compare transcutaneous bilirubin (TcB) measurement, which is a noninvasive, easy, fast and inexpensive method in the treatment of patients with neonatal jaundice, with total serum bilirubin (TSB) measurement values, which is the standard method. Simultaneous capillary tube bilirubin values were also included in the study in terms of correlation. We investigated whether it would be safe to use TcB measurement instead of blood sampling for jaundice assessment. Materials and Methods: Between January 1, 2023 and July 1, 2023, newborns with gestational jaundice aged 37-42 weeks who were hospitalized with neonatal jaundice were enrolled in the neonatal intensive care unit of Gaziosmanpaşa University Faculty of Medicine (Tokat, Turkey). Patients with confirmed neonatal jaundice were retrospectively analyzed. Patients with antenatal or postnatal disease, ABO-Rh blood group incompatibility, and preterm-post-term neonates were excluded from the study. In addition, those who received phototherapy for the first time and did not have a history of transfusion were included in the study. Results: All 72 patients were term neonates. The mean gestational age was 37.26 weeks (range, 37-40 weeks) and the mean weight was 2789 ± 15 g (2255-4550 g). Thirty-one (43.1%) of the newborns were male. The direct Coombs test was 1+ in three newborns and 4+ in one newborn. There was a strong correlation between TcB bilirubin levels and TSB values before and after treatment (r = 0.776, p < 0.001; r = 0.773, p < 0.001, respectively). A strong correlation was observed between capillary tube bilirubin and TSB measurement values before and after treatment (r = 0.875, p < 0.001; r = 0.899, p < 0.001, respectively). Conclusion: In our study, we found a strong correlation between transcutaneous bilirubin measurement, serum bilirubin and capillary tube method performed through the ear before and after phototherapy treatment. However, due to the small size of this study, we cannot recommend the use of transcutaneous measurement alone in making treatment decisions.
{"title":"Correlation of Capillary Tube and Transcutaneous Methods with Serum Biochemistry in Bilirubin Levels in Neonates with Jaundice","authors":"Kazım Darka, Ali Gül","doi":"10.16899/jcm.1434289","DOIUrl":"https://doi.org/10.16899/jcm.1434289","url":null,"abstract":"Objective: The aim of this study was to compare transcutaneous bilirubin (TcB) measurement, which is a noninvasive, easy, fast and inexpensive method in the treatment of patients with neonatal jaundice, with total serum bilirubin (TSB) measurement values, which is the standard method. Simultaneous capillary tube bilirubin values were also included in the study in terms of correlation. We investigated whether it would be safe to use TcB measurement instead of blood sampling for jaundice assessment.\u0000\u0000\u0000Materials and Methods: Between January 1, 2023 and July 1, 2023, newborns with gestational jaundice aged 37-42 weeks who were hospitalized with neonatal jaundice were enrolled in the neonatal intensive care unit of Gaziosmanpaşa University Faculty of Medicine (Tokat, Turkey). Patients with confirmed neonatal jaundice were retrospectively analyzed. Patients with antenatal or postnatal disease, ABO-Rh blood group incompatibility, and preterm-post-term neonates were excluded from the study. In addition, those who received phototherapy for the first time and did not have a history of transfusion were included in the study. \u0000\u0000Results: All 72 patients were term neonates. The mean gestational age was 37.26 weeks (range, 37-40 weeks) and the mean weight was 2789 ± 15 g (2255-4550 g). Thirty-one (43.1%) of the newborns were male. The direct Coombs test was 1+ in three newborns and 4+ in one newborn. There was a strong correlation between TcB bilirubin levels and TSB values before and after treatment (r = 0.776, p < 0.001; r = 0.773, p < 0.001, respectively). A strong correlation was observed between capillary tube bilirubin and TSB measurement values before and after treatment (r = 0.875, p < 0.001; r = 0.899, p < 0.001, respectively).\u0000\u0000Conclusion: In our study, we found a strong correlation between transcutaneous bilirubin measurement, serum bilirubin and capillary tube method performed through the ear before and after phototherapy treatment. However, due to the small size of this study, we cannot recommend the use of transcutaneous measurement alone in making treatment decisions.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":"16 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aims: Congenital heart disease (CHD) is the main cause of death in infants among congenital anomalies. Fetal echocardiography is important for the diagnosis and treatment plan of congenital heart diseases in the prenatal period. This study aimed to retrospectively screen the follow-up and treatment results of cyanotic CHD patients detected on fetal echocardiography. Methods: Fetal echocardiography results were scanned from the hospital record system. Data of fetuses with major cardiac anomalies and cyanotic CHD were examined retrospectively. Results: Fetal echocardiography was performed on 420 pregnant women between July 2020 and April 2023. Major cardiac anomalies and cyanotic heart disease were detected in the fetuses of 40 pregnant women (9.5%) out of 420. The median age of the pregnant women was 29 (19-41 years). The median gestational age at check-up was 23 weeks (22-28 weeks). 9/40 pregnant women (22.5%) had risk factors. The most common cyanotic congenital heart diseases were hypoplastic left heart syndrome (HLHS) and unbalanced complete atrioventricular septal defects (AVSDs) with obstructive lesions of the right or left ventricle. Three fetuses (7.5%) with heart failure findings died intrauterine. Two fetuses with HLHS and critical aortic stenosis (AS) died before being operated on. A patient with complete AVSD, hypoplasia of the left heart chambers, AS, and severe aortic coarctation died due to sepsis during the post-operative follow-up period. Chromosome analysis was performed in 8 patients. Down syndrome was detected in 3 of the patients with complete AVSD. 22q11 deletion and DiGeorge Syndrome were detected in 2 patients with tetralogy of Fallot. Conclusions: Congenital heart diseases and rhythm problems can be safely detected with fetal echocardiography. It is beneficial to perform a fetal echo scan at the appropriate gestational week, especially in fetuses with risk factors and in whom the four chambers view cannot be seen.
{"title":"Current follow-up results of Cyanotic Congenital Heart Diseases detected during Pregnancy in a specific Region","authors":"D. Duman, D. Karpuz","doi":"10.16899/jcm.1444862","DOIUrl":"https://doi.org/10.16899/jcm.1444862","url":null,"abstract":"Background/Aims: Congenital heart disease (CHD) is the main cause of death in infants among congenital anomalies. Fetal echocardiography is important for the diagnosis and treatment plan of congenital heart diseases in the prenatal period. This study aimed to retrospectively screen the follow-up and treatment results of cyanotic CHD patients detected on fetal echocardiography.\u0000Methods: Fetal echocardiography results were scanned from the hospital record system. Data of fetuses with major cardiac anomalies and cyanotic CHD were examined retrospectively.\u0000Results: Fetal echocardiography was performed on 420 pregnant women between July 2020 and April 2023. Major cardiac anomalies and cyanotic heart disease were detected in the fetuses of 40 pregnant women (9.5%) out of 420. The median age of the pregnant women was 29 (19-41 years). The median gestational age at check-up was 23 weeks (22-28 weeks). 9/40 pregnant women (22.5%) had risk factors. \u0000The most common cyanotic congenital heart diseases were hypoplastic left heart syndrome (HLHS) and unbalanced complete atrioventricular septal defects (AVSDs) with obstructive lesions of the right or left ventricle. Three fetuses (7.5%) with heart failure findings died intrauterine. Two fetuses with HLHS and critical aortic stenosis (AS) died before being operated on. A patient with complete AVSD, hypoplasia of the left heart chambers, AS, and severe aortic coarctation died due to sepsis during the post-operative follow-up period. Chromosome analysis was performed in 8 patients. Down syndrome was detected in 3 of the patients with complete AVSD. 22q11 deletion and DiGeorge Syndrome were detected in 2 patients with tetralogy of Fallot.\u0000Conclusions: Congenital heart diseases and rhythm problems can be safely detected with fetal echocardiography. It is beneficial to perform a fetal echo scan at the appropriate gestational week, especially in fetuses with risk factors and in whom the four chambers view cannot be seen.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elif Sena Ozcan, Gulam Hekimoğlu, Sevim Yener, Nurullah Yücel
Schinzel-Giedion syndrome (SGS) is a highly recognizable syndrome characterized by severe mental retardation, distinctive facial features, multiple congenital malformations, and higher-level neurological deficits. Comprehending SGS is essential for customized medical treatment, genetic counseling, and furthering developmental problem research. Enhanced understanding leads to better assistance for impacted people and their families, which improves results overall. In this study, we present a case of SGS associated with 2q35-q37 duplication, 4q34.1 duplication, and 9p24.3-24.1 deletion.
{"title":"Copy Number Alterations Associated with Schinzel-Giedion Syndrome: Case Report","authors":"Elif Sena Ozcan, Gulam Hekimoğlu, Sevim Yener, Nurullah Yücel","doi":"10.16899/jcm.1439851","DOIUrl":"https://doi.org/10.16899/jcm.1439851","url":null,"abstract":"Schinzel-Giedion syndrome (SGS) is a highly recognizable syndrome characterized by severe mental retardation, distinctive facial features, multiple congenital malformations, and higher-level neurological deficits. Comprehending SGS is essential for customized medical treatment, genetic counseling, and furthering developmental problem research. Enhanced understanding leads to better assistance for impacted people and their families, which improves results overall. In this study, we present a case of SGS associated with 2q35-q37 duplication, 4q34.1 duplication, and 9p24.3-24.1 deletion.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":"37 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140374012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Merve Koç Yekedüz, Engin Köse, Ömer Erdeve, F. T. Eminoğlu
Background: Gene therapy is applied to regulate the functions of mutated or disease-causing genes in human cells and targets nucleotides. Recent years have seen an increasing number of publications reporting successful results from gene therapies, suggesting an increasing scientific curiosity among clinicians. Methods: Gene Therapy Symposiums were hosted by the [blinded for review]. The participants answered pre-post-tests, and satisfaction scales. Results: A total of 192 participants underwent training, none of whom had previously undergone gene therapy training. Of the sample, 71.9% were female and the median age of the participants was 32 years. Of the total, 84.9% were studying medicine and 15.1% were studying in non-medical fields. Among those studying medicine, 17.2% were students, 18.4% were main specialty research assistants, 38.0% were subspecialty research assistants, 17.2% were specialists and 9.2% were assistant professors/professors. An analysis of the completed pretests revealed that 32.3% had answered the questions correctly, while 58.6% answered the questions correctly after undergoing training. The overall satisfaction score was 91.8 out of 100. Conclusions: The results of the pretest revealed the knowledge and awareness of gene therapy among the participants to be low, indicating a need for education programs addressing the subject. Gene therapy has moved beyond the theoretical realm in recent years and is today seeing practical applications. There is an urgent need to train the clinicians and other operatives required for the provision of gene therapies and to develop strategies for tertiary care centers in this field over the next 10 years.
{"title":"Türkiye’s First Multidisciplinary Gene Therapy Education Program: History and Plans for the Future","authors":"Merve Koç Yekedüz, Engin Köse, Ömer Erdeve, F. T. Eminoğlu","doi":"10.16899/jcm.1446436","DOIUrl":"https://doi.org/10.16899/jcm.1446436","url":null,"abstract":"Background:\u0000Gene therapy is applied to regulate the functions of mutated or disease-causing genes in human cells and targets nucleotides. Recent years have seen an increasing number of publications reporting successful results from gene therapies, suggesting an increasing scientific curiosity among clinicians. \u0000Methods:\u0000Gene Therapy Symposiums were hosted by the [blinded for review]. The participants answered pre-post-tests, and satisfaction scales. \u0000Results:\u0000A total of 192 participants underwent training, none of whom had previously undergone gene therapy training. Of the sample, 71.9% were female and the median age of the participants was 32 years. Of the total, 84.9% were studying medicine and 15.1% were studying in non-medical fields. Among those studying medicine, 17.2% were students, 18.4% were main specialty research assistants, 38.0% were subspecialty research assistants, 17.2% were specialists and 9.2% were assistant professors/professors. An analysis of the completed pretests revealed that 32.3% had answered the questions correctly, while 58.6% answered the questions correctly after undergoing training. The overall satisfaction score was 91.8 out of 100. \u0000Conclusions:\u0000The results of the pretest revealed the knowledge and awareness of gene therapy among the participants to be low, indicating a need for education programs addressing the subject. Gene therapy has moved beyond the theoretical realm in recent years and is today seeing practical applications. There is an urgent need to train the clinicians and other operatives required for the provision of gene therapies and to develop strategies for tertiary care centers in this field over the next 10 years.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Knowledge about the change in the frequency and characteristics of medical sharps injuries during the Coronavirus Disease–2019 (COVID-19) pandemic is very limited. This study aimed to compare the characteristics of medical sharps injuries experienced by healthcare staff before and during the COVID-19 pandemic. Material and Method: A total of 304 cases of medical sharps injuries suffered by hospital staff in our hospital between 2014 and 2022 were included in the study. Data regarding these accidents were obtained from accident files in the hospital archive. Results: The mean age of the staff exposed to the accident was 30.2±10.7 (range: 15-50) years, and 227 (74.7%) were women. During the pandemic, a 34.6% decrease was detected in the annual mean number of medical sharps injuries compared to before the pandemic. In cases during the pandemic, the annual mean rate of interns who had an accident decreased significantly compared to before the pandemic (43.7% vs. 18.8%), while the mean rate of nurses increased significantly (31.9% vs. 53.2%)(p<0.001), and the annual mean needle tip rate decreased significantly (83.0% vs. 68.0%)(p=0.035). Conclusion: The findings of the present study showed that there was a significant decrease in the number of medical sharps accidents during the pandemic compared to the pre-pandemic period, that the rate of nurses who were exposed to accidents increased significantly during this period, that there was a significant decrease in the rate of needle stick-related accidents, that there was a significant decrease in the accident rate in surgical wards and a significant increase in intensive care units.
{"title":"Change in Medical Sharps Injury Characteristics During the COVID-19 Pandemic","authors":"Emine Sehmen, Esmeray Mutlu Yılmaz","doi":"10.16899/jcm.1371032","DOIUrl":"https://doi.org/10.16899/jcm.1371032","url":null,"abstract":"Aim: Knowledge about the change in the frequency and characteristics of medical sharps injuries during the Coronavirus Disease–2019 (COVID-19) pandemic is very limited. This study aimed to compare the characteristics of medical sharps injuries experienced by healthcare staff before and during the COVID-19 pandemic.\u0000Material and Method: A total of 304 cases of medical sharps injuries suffered by hospital staff in our hospital between 2014 and 2022 were included in the study. Data regarding these accidents were obtained from accident files in the hospital archive.\u0000Results: The mean age of the staff exposed to the accident was 30.2±10.7 (range: 15-50) years, and 227 (74.7%) were women. During the pandemic, a 34.6% decrease was detected in the annual mean number of medical sharps injuries compared to before the pandemic. In cases during the pandemic, the annual mean rate of interns who had an accident decreased significantly compared to before the pandemic (43.7% vs. 18.8%), while the mean rate of nurses increased significantly (31.9% vs. 53.2%)(p<0.001), and the annual mean needle tip rate decreased significantly (83.0% vs. 68.0%)(p=0.035). \u0000Conclusion: The findings of the present study showed that there was a significant decrease in the number of medical sharps accidents during the pandemic compared to the pre-pandemic period, that the rate of nurses who were exposed to accidents increased significantly during this period, that there was a significant decrease in the rate of needle stick-related accidents, that there was a significant decrease in the accident rate in surgical wards and a significant increase in intensive care units.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":" 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To investigate the potential relation between dynamic thiol homeostasis and blood transfusion in the pediatric intensive care unit. Methods: Blood samples were collected from pediatric intensive care patients before and after erythrocyte suspension transfusion and from donor blood additionally to measure thiol levels. The study involved 30 patients, including nine females, and a total of 90 blood samples from patients and donors were analyzed. Results: Prior to transfusion, Total Thiol (TT) and Native Thiol (NT) were 414.77 ± 156.14 (μmol/L) and 272.63 ± 115.75 (μmol/L), respectively, and post-transfusion, they were found to decrease to 398.07 ± 187.38 (μmol/L) and 258.97 ± 136.2 (μmol/L), respectively. However, no statistically significant difference was observed between pre- and post-transfusion values. In post-transfusion blood samples, there was a significant increase in Disulfide/TT and Disulfide/NT ratios, indicating an increase in oxidation (34.79 ± 92.34 and 51.89 ± 68.51, respectively), yet no statistical difference was noted. Conclusion: Transfusions administered in the Pediatric Intensive Care Unit were associated with a decrease in total and native thiol levels, indicative of increased oxidative stress, despite the lack of statistically significant differences. To mitigate the potential negative impact on patients with high oxidative properties after transfusions, strengthening the antioxidant defense system is recommended. Research should be planned to develop suitable strategies for enhancing the antioxidant defense system and ensuring patients' resilience to this condition.
{"title":"Effect of Erythrocyte Suspension Transfusion on Thiol-Disulfide Homeostasis in Critically Ill Children","authors":"Resul Yılmaz","doi":"10.16899/jcm.1408942","DOIUrl":"https://doi.org/10.16899/jcm.1408942","url":null,"abstract":"Objective: To investigate the potential relation between dynamic thiol homeostasis and blood transfusion in the pediatric intensive care unit. \u0000Methods: Blood samples were collected from pediatric intensive care patients before and after erythrocyte suspension transfusion and from donor blood additionally to measure thiol levels. The study involved 30 patients, including nine females, and a total of 90 blood samples from patients and donors were analyzed. \u0000Results: Prior to transfusion, Total Thiol (TT) and Native Thiol (NT) were 414.77 ± 156.14 (μmol/L) and 272.63 ± 115.75 (μmol/L), respectively, and post-transfusion, they were found to decrease to 398.07 ± 187.38 (μmol/L) and 258.97 ± 136.2 (μmol/L), respectively. However, no statistically significant difference was observed between pre- and post-transfusion values. In post-transfusion blood samples, there was a significant increase in Disulfide/TT and Disulfide/NT ratios, indicating an increase in oxidation (34.79 ± 92.34 and 51.89 ± 68.51, respectively), yet no statistical difference was noted. \u0000Conclusion: Transfusions administered in the Pediatric Intensive Care Unit were associated with a decrease in total and native thiol levels, indicative of increased oxidative stress, despite the lack of statistically significant differences. To mitigate the potential negative impact on patients with high oxidative properties after transfusions, strengthening the antioxidant defense system is recommended. Research should be planned to develop suitable strategies for enhancing the antioxidant defense system and ensuring patients' resilience to this condition.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. D. Demirkıran, R. Özmanevra, S. Öner, Süleyman Kozlu, T. Dülgeroğlu
Background: The purpose of this study is to describe the macroscopic and radiological changes on the fifth finger related to mobile phone use and to evaluate the effect of size and weight of the device and the average time spent using the smartphone on these morphological alterations. Methods: One-hundred and one patient were included in the study. Age, weight, height, education, mobile phone data and digital photographs used in this cross-sectional study were obtained from interviews with the participants in an outpatient orthopedics clinic setting. Digital photographs of the dorsal aspects of both hands were taken with an iPhone X ® (dual 12-megapixel wide camera). The DIP joint angle of the fifth finger was measured on computer software (Image J® version 1.46, National Institute of Health, Bethesda, MD) separately for digital photographs and AP hand X-rays. Results: The proportion of smartphone usage time over 4 hours was significantly higher in patients with complaints than patients without complaints (p<0.05). The mean time of smartphone use over 4 hours was significantly higher in patients with shape discrepancy than in patients without shape discrepancy (p<0.05). Conclusion: Smartphone use of more than 4 hours per day, regardless of size and weight, can cause deformity of the fifth finger, which may disturb the patient even if it does not cause radiologically changes.
{"title":"An Investigation On The Effect Of Smartphone Use On Morphological And Radiological Changes Of The Fifth Finger","authors":"N. D. Demirkıran, R. Özmanevra, S. Öner, Süleyman Kozlu, T. Dülgeroğlu","doi":"10.16899/jcm.1401015","DOIUrl":"https://doi.org/10.16899/jcm.1401015","url":null,"abstract":"Background: The purpose of this study is to describe the macroscopic and radiological changes on the fifth finger related to mobile phone use and to evaluate the effect of size and weight of the device and the average time spent using the smartphone on these morphological alterations.\u0000\u0000Methods: One-hundred and one patient were included in the study. Age, weight, height, education, mobile phone data and digital photographs used in this cross-sectional study were obtained from interviews with the participants in an outpatient orthopedics clinic setting. Digital photographs of the dorsal aspects of both hands were taken with an iPhone X ® (dual 12-megapixel wide camera). The DIP joint angle of the fifth finger was measured on computer software (Image J® version 1.46, National Institute of Health, Bethesda, MD) separately for digital photographs and AP hand X-rays.\u0000\u0000Results: The proportion of smartphone usage time over 4 hours was significantly higher in patients with complaints than patients without complaints (p<0.05). The mean time of smartphone use over 4 hours was significantly higher in patients with shape discrepancy than in patients without shape discrepancy (p<0.05).\u0000\u0000Conclusion: Smartphone use of more than 4 hours per day, regardless of size and weight, can cause deformity of the fifth finger, which may disturb the patient even if it does not cause radiologically changes.","PeriodicalId":15449,"journal":{"name":"Journal of contemporary medicine","volume":" 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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